{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T09:21:30Z","timestamp":1778750490804,"version":"3.51.4"},"reference-count":28,"publisher":"American Veterinary Medical Association (AVMA)","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2025,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec id=\"sc_a1\">\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>To document objective metrics of attenuation of the pulmonary parenchyma on inspiratory and expiratory breath-hold CT in dogs with bronchomalacia (BM) and dogs without BM (NoBM) using automated software analysis. Metrics included mean lung attenuation, percent low-attenuation area at \u2212856 HU, percent high-attenuation area at \u2212700 HU, and percent attenuation area between \u2212600 and \u2212250 HU.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a2\">\n<jats:title>ANIMALS<\/jats:title>\n<jats:p>Client-owned dogs with BM (n = 123) and NoBM (20).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a3\">\n<jats:title>METHODS<\/jats:title>\n<jats:p>This retrospective study utilized 3D Slicer software (Brigham and Women's Hospital) to assess pulmonary CT attenuation. Analysis used Spearman correlation and 2-way ANOVA with beta regression.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a4\">\n<jats:title>RESULTS<\/jats:title>\n<jats:p>Comparing the difference between inspiratory and expiratory phases, there was a significantly greater increase in mean lung attenuation (<jats:italic>P<\/jats:italic> = .001), a significant reduction in percent low-attenuation area at \u2212856 HU (<jats:italic>P<\/jats:italic> = .016), and a significant increase in percent high-attenuation area at \u2212700 HU and percent attenuation area between \u2212600 and \u2212250 HU (<jats:italic>P<\/jats:italic> &lt; .001 and <jats:italic>P<\/jats:italic> &lt; .0001, respectively) in BM versus NoBM dogs.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a5\">\n<jats:title>CONCLUSIONS<\/jats:title>\n<jats:p>The higher inspiratory and expiratory difference in lung attenuation in BM compared to NoBM dogs supports the presence of impaired parenchymal aeration downstream of segmental and subsegmental airway collapse.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a6\">\n<jats:title>CLINICAL RELEVANCE<\/jats:title>\n<jats:p>Quantitative image analysis holds promise for objectively evaluating changes with BM.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/ajvr.24.07.0186","type":"journal-article","created":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T13:37:06Z","timestamp":1732541826000},"source":"Crossref","is-referenced-by-count":2,"title":["Objective assessment of computed tomographic pulmonary attenuation of inspiratory and expiratory series in dogs with and without bronchomalacia"],"prefix":"10.2460","volume":"86","author":[{"given":"Charlotte","family":"Gerhard","sequence":"first","affiliation":[{"name":"Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, Columbia, MO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Masseau","sequence":"additional","affiliation":[{"name":"D\u00e9partement des Sciences Cliniques, Facult\u00e9 de M\u00e9decine V\u00e9t\u00e9rinaire, Universit\u00e9 de Montr\u00e9al, St-Hyacinthe, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aida","family":"Vientos-Plotts","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, Columbia, MO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory F.","family":"Petroski","sequence":"additional","affiliation":[{"name":"Office of Medical Research, Biostatistics Unit, University of Missouri, Columbia, MO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol","family":"Reinero","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, Columbia, MO"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"issue":"1","key":"B1","series-title":"Radiographics","first-page":"28","article-title":"Quantitative CT analysis of diffuse lung disease","volume":"40","author":"Chen A","year":"2020","unstructured":"Chen A, Karwoski RA, Gierada DS, Bartholmai BJ, Koo CW. 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