{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T08:11:04Z","timestamp":1747210264948,"version":"3.40.5"},"reference-count":24,"publisher":"American Veterinary Medical Association (AVMA)","issue":"12","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2024,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec id=\"sc_a1\">\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>To assess the pharmacokinetics and sedative effects of a single administration of oral gabapentin in African cheetahs (<jats:italic>Acinonyx jubatus<\/jats:italic>) at 2 different dosages.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a2\">\n<jats:title>METHODS<\/jats:title>\n<jats:p>Adult cheetahs (n = 16) located at 3 different zoological institutions were prospectively enrolled to receive single doses of gabapentin administered at 2 different dosages (10 mg\/kg and 20 mg\/kg). Venipuncture was performed under behavioral restraint at predetermined time points over a 24-hour period using a sparse sampling model. Plasma concentrations of gabapentin were determined using high-performance liquid chromatography. A modified domestic felid sedation scoring system was used to assess animals at each time point by 3 masked scorers, and sedation scores were compared between time points.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a3\">\n<jats:title>RESULTS<\/jats:title>\n<jats:p>Mean \u00b1 SE maximal plasma concentrations were 24.0 \u00b1 12.8 \u03bcg\/mL and 31.4 \u00b1 8.57 \u03bcg\/mL for the 10- and 20-mg\/kg dosages, respectively. For both dosages, concentrations remained elevated at the final collection time point of 24 hours (2.39 \u00b1 1.97 and 3.93 \u00b1 3.09 \u03bcg\/mL for 10 and 20 mg\/kg, respectively). Mild sedation was achieved for both doses up to 24 hours postadministration, with no significant differences between dosages.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a4\">\n<jats:title>CONCLUSIONS<\/jats:title>\n<jats:p>Gabapentin was well absorbed following oral administration, and concentrations remained elevated 24 hours postadministration. Gabapentin produces mild sedation at 10 or 20 mg\/kg for up to 24 hours.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a5\">\n<jats:title>CLINICAL RELEVANCE<\/jats:title>\n<jats:p>Gabapentin given to cheetahs at these dosages is a useful tool for improving patient welfare due to its mild sedative effects over a clinically relevant time period.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/ajvr.24.07.0200","type":"journal-article","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T17:15:54Z","timestamp":1726506954000},"source":"Crossref","is-referenced-by-count":0,"title":["Pharmacokinetics and sedative effects of single-dose oral gabapentin in cheetahs (Acinonyx jubatus)"],"prefix":"10.2460","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0613-6497","authenticated-orcid":true,"given":"Melanie J.","family":"Peel","sequence":"first","affiliation":[{"name":"School of Veterinary Medicine, University of California-Davis, Davis, CA"},{"name":"San Diego Zoo Wildlife Alliance, San Diego, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather","family":"Knych","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, University of California-Davis, Davis, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew E.","family":"Kinney","sequence":"additional","affiliation":[{"name":"San Diego Zoo Wildlife Alliance, San Diego, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Nevitt","sequence":"additional","affiliation":[{"name":"San Diego Zoo Wildlife Alliance, San Diego, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Analisa","family":"Edell","sequence":"additional","affiliation":[{"name":"Wildlife Safari, Winston, OR"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra L.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Statistics, University of California-Davis, Davis, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zainab","family":"Akinjobi","sequence":"additional","affiliation":[{"name":"Department of Statistics, University of California-Davis, Davis, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenessa","family":"Gjeltema","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, University of California-Davis, Davis, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"issue":"50","key":"B1","series-title":"Proc Natl Acad Sci USA","first-page":"24911","article-title":"News feature: getting the world\u2019s fastest cat to breed with speed","volume":"116","author":"McDermott A","year":"2019","unstructured":"McDermott A. 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