{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T05:07:51Z","timestamp":1785388071094,"version":"3.55.0"},"reference-count":38,"publisher":"American Veterinary Medical Association (AVMA)","issue":"12","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2024,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec id=\"sc_a1\">\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>The aim of this study was to evaluate the CT features of pulmonary metastases in dogs with hemangiosarcoma (HSA) at various sites. Additionally, the CT characteristics of extrapulmonary metastases in the same population were assessed.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a2\">\n<jats:title>METHODS<\/jats:title>\n<jats:p>Retrospective, observational, and descriptive study conducted from April 2013 to January 2024. Dogs with histologically confirmed HSA and suspected or cytologically\/histologically confirmed lung metastases were included. Dogs were excluded if they had a second primary tumor or only 1 unsampled pulmonary nodule.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a3\">\n<jats:title>RESULTS<\/jats:title>\n<jats:p>33 dogs were included, with 26\/33 [78.8%] having more than 10 metastatic pulmonary nodules. Most nodules were generalized (24\/33 [72.7%]), miliary (29\/33 [87.9%]) to subcentimetric (32\/33 [97%]) in size, well-defined margins (29\/33 [87.9%]), or a perilesional halo sign (24\/33 [72.7%]). When more than 10 nodules were present, a generalized distribution was prevalent, while a peripheral location was more common when 2 to 10 nodules were present (<jats:italic>P<\/jats:italic> &lt; .0001). In 32\/33 (97%) cases, a pulmonary vessel was directly connected to the nodule (feeding vessel). After contrast administration, most lung metastases appeared homogenous (26\/33 [78.8%]), although some showed areas of intense enhancement (5\/33 [15.1%]) a feature also observed in extrapulmonary metastases with varying frequency (0% to 85.7%).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a4\">\n<jats:title>CONCLUSIONS<\/jats:title>\n<jats:p>Pulmonary HSA metastases were characterized by generalized, small (miliary\/subcentimetric), well-defined nodules, commonly associated with a halo sign and feeding vessel. Intralesional areas of spotty postcontrast linear or amorphous strong hyperdensity were frequently observed especially in extrapulmonary metastases.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a5\">\n<jats:title>CLINICAL RELEVANCE<\/jats:title>\n<jats:p>These features may help radiologists and clinicians orient their diagnosis toward metastatic HSA.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/ajvr.24.08.0219","type":"journal-article","created":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T14:48:15Z","timestamp":1727966895000},"source":"Crossref","is-referenced-by-count":7,"title":["Computed tomographic features of pulmonary and extrapulmonary lesions can be useful in prioritizing the diagnosis of hemangiosarcoma metastases in dogs"],"prefix":"10.2460","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0065-2952","authenticated-orcid":true,"given":"Mirko","family":"Mattolini","sequence":"first","affiliation":[{"name":"AniCura Clinica Veterinaria Dell'Orologio, Sasso Marconi, Bologna, Italy"},{"name":"Department of Veterinary Sciences, University of Pisa, San Piero a Grado, Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8211-9248","authenticated-orcid":true,"given":"Simonetta","family":"Citi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences, University of Pisa, San Piero a Grado, Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6797-397X","authenticated-orcid":true,"given":"Roberta","family":"Franchi","sequence":"additional","affiliation":[{"name":"AniCura Clinica Veterinaria Dell'Orologio, Sasso Marconi, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5672-7856","authenticated-orcid":true,"given":"Valentina","family":"Meucci","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences, University of Pisa, San Piero a Grado, Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3281-1414","authenticated-orcid":true,"given":"Gregorio","family":"Carozzi","sequence":"additional","affiliation":[{"name":"AniCura Clinica Veterinaria Dell'Orologio, Sasso Marconi, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8925-3291","authenticated-orcid":true,"given":"Beatrice","family":"Gianni","sequence":"additional","affiliation":[{"name":"AniCura Clinica Veterinaria Dell'Orologio, Sasso Marconi, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7951-3726","authenticated-orcid":true,"given":"Elvanessa","family":"Caleri","sequence":"additional","affiliation":[{"name":"AniCura Clinica Veterinaria Dell'Orologio, Sasso Marconi, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6402-930X","authenticated-orcid":true,"given":"Federica","family":"Rossi","sequence":"additional","affiliation":[{"name":"AniCura Clinica Veterinaria Dell'Orologio, Sasso Marconi, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"B1","series-title":"Withrow and MacEwen's Small Animal Clinical Oncology","author":"Vail DM","year":"2019","unstructured":"Vail DM, Thamm DH, Liptak JM. 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