{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T21:10:47Z","timestamp":1784754647782,"version":"3.55.0"},"reference-count":42,"publisher":"American Veterinary Medical Association (AVMA)","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2025,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec id=\"sc_a1\">\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>To evaluate the potential contribution of glycyrrhizin (GLZ) to mitigate the testicular toxicity linked to cisplatin (CIS) intoxication.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a2\">\n<jats:title>METHODS<\/jats:title>\n<jats:p>40 mature male Wistar albino rats (<jats:italic>Rattus norvegicus albinus<\/jats:italic>) were randomly divided into 4 equal groups (n = 10) for 60 days: the control group, CIS-treated group (single dose of 7 mg\/kg, IP), GLZ-treated group (25 mg\/kg, PO), and GLZ plus CIS\u2013treated group. Blood and testis samples were examined using biochemical, histological, and immunohistochemical techniques. Semen samples were also obtained, and any abnormalities were reported.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a3\">\n<jats:title>RESULTS<\/jats:title>\n<jats:p>Serum follicle-stimulating hormone, luteinizing hormone, and testosterone levels were all markedly reduced by CIS. Oxidative stress and a significant reduction in levels of the antioxidant enzymes glutathione peroxidase, superoxide dismutase, and catalase were linked to CIS. Immunohistochemically, CIS showed diffuse, significantly positive immunolocalizations against the anti-caspase 3 antibody, indicating widespread apoptosis within the testicular parenchyma. Histopathologically, CIS showed diffuse coagulative necrosis of spermatogenic cells, necrotic Sertoli cells, intertubular edema, and Leydig cell hyperplasia. Moreover, CIS revealed a noteworthy increase in sperm abnormalities. Pre-coadministration and posttreatment with GLZ mitigated the majority of these detrimental consequences, and serum levels of antioxidant enzymes, luteinizing hormone, follicle-stimulating hormone, and testosterone were significantly elevated.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a4\">\n<jats:title>CONCLUSIONS<\/jats:title>\n<jats:p>Glycyrrhizin has been proven to be a strong antioxidant as well as antiapoptotic and cytoprotective against CIS testicular damage.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a5\">\n<jats:title>CLINICAL RELEVANCE<\/jats:title>\n<jats:p>The described model is a tool to evaluate the testicular protective impact of GLZ.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/ajvr.24.10.0288","type":"journal-article","created":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T19:42:13Z","timestamp":1731008533000},"source":"Crossref","is-referenced-by-count":4,"title":["Glycyrrhizin alleviated cisplatin-induced testicular injury by inhibiting the oxidative, apoptotic, hormonal, and histological alterations"],"prefix":"10.2460","volume":"86","author":[{"given":"Fawiziah Khalaf","family":"Alharbi","sequence":"first","affiliation":[{"name":"Department of Biology, College of Science, Qassim University, Buraydah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lashin Saad","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, Faculty of Dentistry, Al-Ahliyya Amman University, Amman, Jordan"},{"name":"Department of Physiology, Faculty of Medicine, Mansoura University, Mansoura, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gamal A.","family":"Salem","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naira","family":"ElAshmouny","sequence":"additional","affiliation":[{"name":"Department of Histology and Cell Biology, Faculty of Medicine, Kafr Elsheikh University, Kafr Elsheikh, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanad S.","family":"El-Kholy","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, Kafr Elsheikh University, Kafr Elsheikh, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walaa M.","family":"Essawi","sequence":"additional","affiliation":[{"name":"Department of Theriogenology, Faculty of Veterinary Medicine, Aswan University, Aswan, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azza I","family":"Helal","sequence":"additional","affiliation":[{"name":"Department of Histology and Cell Biology, Faculty of Medicine, Kafr Elsheikh University, Kafr Elsheikh, Egypt"},{"name":"Department of Histology and Cell Biology, Faculty of Medicine, New Mansoura University, New Mansoura, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hany Sabry A.","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Department of Andrology, International Islamic Center of Population Studies and Researches, Alazhar University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naief","family":"Dahran","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, College of Medicine, University of Jeddah, Jeddah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eman S.","family":"El-Shetry","sequence":"additional","affiliation":[{"name":"Department of Anatomy, College of Medicine, University of Hail, Hail, Saudi Arabia"},{"name":"Department of Human Anatomy and Embryology, Faculty of Medicine, Zagazig University, Zagazig, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rania Hassan Mohamed","family":"Soliman","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy and Embryology, Faculty of Medicine, Zagazig University, Zagazig, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan","family":"Emam","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamdouh","family":"Eldesoqui","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, College of Medicine, AlMaarefa University, Riyadh, Saudi Arabia"},{"name":"Department of Anatomy and Embryology, Faculty of Medicine, Mansoura University, Mansoura, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahmy Gad","family":"Elsaid","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Science, King Khalid University, Asir, Abha, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fawziah A.","family":"Al-Salmi","sequence":"additional","affiliation":[{"name":"Biology Department, College of Sciences, Taif University, Taif, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doaa","family":"Abdelrahaman","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eman","family":"Fayad","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, College of Sciences, Taif University, Taif, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdel-rahman A.","family":"Sobeih","sequence":"additional","affiliation":[{"name":"Department of Animal Wealth Development, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1324-0655","authenticated-orcid":true,"given":"Wael A. M.","family":"Ghonimi","sequence":"additional","affiliation":[{"name":"Department of Histology and Cytology, Faculty of Veterinary Medicine, Zagazig University Zagazig, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"issue":"4","key":"B1","series-title":"Hum Reprod Update","first-page":"363","article-title":"Testicular function following chemotherapy","volume":"7","author":"Howell SJ","year":"2001","unstructured":"Howell SJ, Shalet SM. Testicular function following chemotherapy. Hum Reprod Update. 2001;7(4):363\u2013369. doi:10.1093\/humupd\/7.4.363"},{"key":"B2","series-title":"Eur J Obstet Gynecol Reprod Biol","first-page":"S2","article-title":"Testicular function following chemo-radiotherapy","volume":"113","author":"Colpi GM","year":"2004","unstructured":"Colpi GM, Contalbi GF, Nerva F, Sagone P, Piediferro G. Testicular function following chemo-radiotherapy. Eur J Obstet Gynecol Reprod Biol. 2004;113(suppl 1):S2\u2013S6. doi:10.1016\/j.ejogrb.2003.11.002"},{"issue":"34","key":"B3","series-title":"J Natl Cancer Inst Monogr","first-page":"12","article-title":"Spermatogenesis after cancer treatment: damage and recovery","volume":"34","author":"Howell SJ","year":"2005","unstructured":"Howell SJ, Shalet SM. Spermatogenesis after cancer treatment: damage and recovery. J Natl Cancer Inst Monogr. 2005;34(34):12\u201317. doi:10.1093\/jncimonographs\/lgi003"},{"key":"B4","series-title":"Eur J Pharmacol","first-page":"364","article-title":"Cisplatin in cancer therapy: molecular mechanisms of action","volume":"740","author":"Dasari S","year":"2014","unstructured":"Dasari S, Tchounwou PB. Cisplatin in cancer therapy: molecular mechanisms of action. Eur J Pharmacol. 2014;740:364\u2013378. doi:10.1016\/j.ejphar.2014.07.025"},{"issue":"5","key":"B5","series-title":"Andrologia","first-page":"553","article-title":"Cisplatin-induced testicular dysfunction and its amelioration by Launaea taraxacifolia leaf extract","volume":"47","author":"Adejuwon SA","year":"2015","unstructured":"Adejuwon SA, Femi-Akinlosotu OM, Omirinde JO. Cisplatin-induced testicular dysfunction and its amelioration by Launaea taraxacifolia leaf extract. Andrologia. 2015;47(5):553\u2013559. doi:10.1111\/and.12302"},{"issue":"5","key":"B6","series-title":"Theranostics","first-page":"2115","article-title":"Platinum-based drugs for cancer therapy and anti-tumor strategies","volume":"12","author":"Zhang C","year":"2022","unstructured":"Zhang C, Xu C, Gao X, Yao Q. Platinum-based drugs for cancer therapy and anti-tumor strategies. Theranostics. 2022;12(5):2115\u20132132. doi:10.7150\/thno.69424"},{"issue":"15","key":"B7","series-title":"Int J Mol Sci","first-page":"8199","article-title":"Targeting DNA damage response and repair to enhance therapeutic index in cisplatin-based cancer treatment","volume":"22","author":"Kiss RC","year":"2021","unstructured":"Kiss RC, Xia F, Acklin S. Targeting DNA damage response and repair to enhance therapeutic index in cisplatin-based cancer treatment. Int J Mol Sci. 2021;22(15):8199. doi:10.3390\/ijms22158199"},{"issue":"4","key":"B8","series-title":"Nat Rev Drug Discov","first-page":"307","article-title":"Cellular processing of platinum anticancer drugs","volume":"4","author":"Wang D","year":"2005","unstructured":"Wang D, Lippard SJ. Cellular processing of platinum anticancer drugs. Nat Rev Drug Discov. 2005;4(4):307\u2013320. doi:10.1038\/nrd1691"},{"key":"B9","series-title":"Biochem Pharmacol","first-page":"115323","article-title":"Cisplatin in cancer treatment","volume":"206","author":"Romani AMP","year":"2022","unstructured":"Romani AMP. Cisplatin in cancer treatment. Biochem Pharmacol. 2022;206:115323. doi:10.1016\/j.bcp.2022.115323"},{"issue":"1","key":"B10","series-title":"Reprod Toxicol","first-page":"42","article-title":"Protective role of lycopene on cisplatin-induced changes in sperm characteristics, testicular damage and oxidative stress in rats","volume":"21","author":"Ate\u015f\u015fahin A","year":"2006","unstructured":"Ate\u015f\u015fahin A, Karahan I, T\u00fcrk G, G\u00fcr S, Yilmaz S, Ceriba\u015fi AO. Protective role of lycopene on cisplatin-induced changes in sperm characteristics, testicular damage and oxidative stress in rats. Reprod Toxicol. 2006;21(1):42\u201347. doi:10.1016\/j.reprotox.2005.05.003"},{"issue":"1","key":"B11","series-title":"J Pineal Res","first-page":"21","article-title":"Chemoprotective effect of melatonin against cisplatin-induced testicular toxicity in rats","volume":"41","author":"Ate\u015f\u015fahin A","year":"2006","unstructured":"Ate\u015f\u015fahin A, Sahna E, T\u00fcrk G, et al. Chemoprotective effect of melatonin against cisplatin-induced testicular toxicity in rats. J Pineal Res. 2006;41(1):21\u201327. doi:10.1111\/j.1600-079X.2006.00327.x"},{"issue":"5","key":"B12","series-title":"Fertil Steril","first-page":"1474","article-title":"Improvement of cisplatin-induced injuries to sperm quality, the oxidant-antioxidant system, and the histologic structure of the rat testis by ellagic acid","volume":"89","author":"T\u00fcrk G","year":"2008","unstructured":"T\u00fcrk G, Ate\u015f\u015fahin A, S\u00f6nmez M, Ceriba\u015fi AO, Y\u00fcce A. Improvement of cisplatin-induced injuries to sperm quality, the oxidant-antioxidant system, and the histologic structure of the rat testis by ellagic acid. Fertil Steril. 2008;89(5)(suppl):1474\u20131481. doi:10.1016\/j.fertnstert.2007.04.059"},{"issue":"4","key":"B13","series-title":"Biomed Prev Nutr","first-page":"265","article-title":"Ameliorative effect of the crude oil of the Nigella sativa on oxidative stress induced in rat testes by cisplatin treatment","volume":"2","author":"Awadalla E","year":"2012","unstructured":"Awadalla E. Ameliorative effect of the crude oil of the Nigella sativa on oxidative stress induced in rat testes by cisplatin treatment. Biomed Prev Nutr. 2012; 2(4):265\u2013268. doi:https:\/\/doi.org\/10.1016\/j.bionut.2012.08.005"},{"issue":"3","key":"B14","series-title":"Middle East Fertil Soc J","first-page":"200","article-title":"Histomorphometric effects of Kigelia africana (Bignoniaceae) fruit extract on the testis following short-term treatment with cisplatin in male Sprague-Dawley rats","volume":"15","author":"Azu O","year":"2010","unstructured":"Azu O, Duru FIO, Osinubi AA, et al. Histomorphometric effects of Kigelia africana (Bignoniaceae) fruit extract on the testis following short-term treatment with cisplatin in male Sprague-Dawley rats. Middle East Fertil Soc J. 2010;15(3):200\u2013208. doi:10.1016\/j.mefs.2010.07.001"},{"issue":"2","key":"B15","series-title":"Pharmacol Res","first-page":"145","article-title":"Effects of the antioxidants curcumin or selenium on cisplatin-induced nephrotoxicity and lipid peroxidation in rats","volume":"43","author":"Antunes LM","year":"2001","unstructured":"Antunes LM, Darin JD, Bianchi NL. Effects of the antioxidants curcumin or selenium on cisplatin-induced nephrotoxicity and lipid peroxidation in rats. Pharmacol Res. 2001;43(2):145\u2013150. doi:10.1006\/phrs.2000.0724"},{"issue":"7","key":"B16","series-title":"Hum Reprod","first-page":"1717","article-title":"Protective effect of curcumin in cisplatin-induced oxidative injury in rat testis: mitogen-activated protein kinase and nuclear factor-kappa B signaling pathways","volume":"24","author":"Ilbey YO","year":"2009","unstructured":"Ilbey YO, Ozbek E, Cekmen M, Simsek A, Otunctemur A, Somay A. Protective effect of curcumin in cisplatin-induced oxidative injury in rat testis: mitogen-activated protein kinase and nuclear factor-kappa B signaling pathways. Hum Reprod. 2009;24(7):1717\u20131725. doi:10.1093\/humrep\/dep058"},{"issue":"6","key":"B17","series-title":"Saudi J Biol Sci","first-page":"1162","article-title":"Protective effect of some plant oils on diazinon induced hepatorenal toxicity in male rats","volume":"24","author":"Al-Attar AM","year":"2017","unstructured":"Al-Attar AM, Elnaggar MHR, Almalki EA. Protective effect of some plant oils on diazinon induced hepatorenal toxicity in male rats. Saudi J Biol Sci. 2017;24(6):1162\u20131171. doi:10.1016\/j.sjbs.2016.10.013"},{"issue":"1","key":"B18","series-title":"Nutr Cancer","first-page":"1\u201311","article-title":"Licorice and cancer","volume":"39","author":"Wang ZY","year":"2001","unstructured":"Wang ZY, Nixon DW. Licorice and cancer. Nutr Cancer. 2001;39(1):1\u201311. doi:10.1207\/S15327914nc391_110.1207\/S15327914nc391_1"},{"issue":"5","key":"B19","series-title":"Biol Pharm Bull","first-page":"884","article-title":"Glabridin alleviates inflammation and nociception in rodents by activating BKC a channels and reducing NO levels","volume":"43","author":"Parlar A","year":"2020","unstructured":"Parlar A, Arslan SO, \u00c7am SA. Glabridin alleviates inflammation and nociception in rodents by activating BKC a channels and reducing NO levels. Biol Pharm Bull. 2020;43(5):884\u2013897. doi:10.1248\/bpb.b20-00038"},{"issue":"3","key":"B20","series-title":"Toxicology","first-page":"239","article-title":"Cytoprotective effects of Glycyrrhizae radix extract and its active component liquiritigenin against cadmium-induced toxicity (effects on bad translocation and cytochrome c-mediated PARP cleavage)","volume":"197","author":"Kim SC","year":"2004","unstructured":"Kim SC, Byun SH, Yang CH, Kim CY, Kim JW, Kim SG. Cytoprotective effects of Glycyrrhizae radix extract and its active component liquiritigenin against cadmium-induced toxicity (effects on bad translocation and cytochrome c-mediated PARP cleavage). Toxicology. 2004;197(3):239\u2013251. doi:10.1016\/j.tox.2004.01.010"},{"issue":"3","key":"B21","series-title":"J Ethnopharmacol","first-page":"781","article-title":"Liquorice, a unique \u201cguide drug\u201d of traditional Chinese medicine: a review of its role in drug interactions","volume":"150","author":"Wang X","year":"2013","unstructured":"Wang X, Zhang H, Chen L, Shan L, Fan G, Gao X. Liquorice, a unique \u201cguide drug\u201d of traditional Chinese medicine: a review of its role in drug interactions. J Ethnopharmacol. 2013;150(3):781\u2013790. doi:10.1016\/j.jep.2013.09.055"},{"issue":"1","key":"B22","series-title":"Exp Anim","first-page":"11","article-title":"Licorice extract does not impair the male reproductive function of rats","volume":"57","author":"Shin S","year":"2008","unstructured":"Shin S, Jang JY, Choi BI, et al. Licorice extract does not impair the male reproductive function of rats. Exp Anim. 2008;57(1):11\u201317. doi:10.1538\/expanim.57.11"},{"issue":"1","key":"B23","series-title":"Indian J Exp Biol","first-page":"58","article-title":"Protective effect of Pongamia pinnata flowers against cisplatin and gentamicin induced nephrotoxicity in rats","volume":"41","author":"Shirwaikar A","year":"2003","unstructured":"Shirwaikar A, Malini S, Kumari SC. Protective effect of Pongamia pinnata flowers against cisplatin and gentamicin induced nephrotoxicity in rats. Indian J Exp Biol. 2003;41(1):58\u201362."},{"key":"B24","series-title":"Int J Herb Med","first-page":"132","article-title":"Glycyrrhiza glabra (liquorice) - a potent medicinal herb","volume":"2","author":"Damle M","year":"2014","unstructured":"Damle M. Glycyrrhiza glabra (liquorice) - a potent medicinal herb. Int J Herb Med. 2014;2:132\u2013136."},{"issue":"1","key":"B25","series-title":"Indian J Physiol Pharmacol","first-page":"6","article-title":"Herbal induced hepatoprotection and hepatotoxicity: a critical review","volume":"60","author":"Bedi O","year":"2016","unstructured":"Bedi O, Bijjem KRV, Kumar P, Gauttam V. Herbal induced hepatoprotection and hepatotoxicity: a critical review. Indian J Physiol Pharmacol. 2016;60(1):6\u201321."},{"issue":"4","key":"B26","series-title":"Toxicol Res (Camb)","first-page":"677","article-title":"The modulatory impacts of Glycyrrhiza glabra extract against methotrexate-induced testicular dysfunction and oxidative stress","volume":"10","author":"Aldhahrani A","year":"2021","unstructured":"Aldhahrani A, Soliman MM, Althobaiti F, et al. The modulatory impacts of Glycyrrhiza glabra extract against methotrexate-induced testicular dysfunction and oxidative stress. Toxicol Res (Camb). 2021;10(4):677\u2013686. doi:10.1093\/toxres\/tfab049"},{"issue":"3","key":"B27","series-title":"Drug Chem Toxicol","first-page":"300","article-title":"Protective effects of glycyrrhizin on sub-chronic diazinon-induced biochemical, hematological alterations and oxidative stress indices in male Wistar rats","volume":"42","author":"Karimani A","year":"2019","unstructured":"Karimani A, Heidarpour M, Moghaddam Jafari A. Protective effects of glycyrrhizin on sub-chronic diazinon-induced biochemical, hematological alterations and oxidative stress indices in male Wistar rats. Drug Chem Toxicol. 2019;42(3):300\u2013308. doi:10.1080\/01480545.2018.1497053"},{"issue":"1","key":"B28","series-title":"BMC Urol","first-page":"117","article-title":"The protective effect of crocin on cisplatin-induced testicular impairment in rats","volume":"21","author":"Mesbahzadeh B","year":"2021","unstructured":"Mesbahzadeh B, Hassanzadeh-Taheri M, Aliparast MS, Baniasadi P, Hosseini M. The protective effect of crocin on cisplatin-induced testicular impairment in rats. BMC Urol. 2021;21(1):117. doi:10.1186\/s12894-021-00889-2"},{"key":"B29","series-title":"Bancroft's Theory and Practice of Histological Techniques","first-page":"83","author":"Suvarna SK","year":"2018","unstructured":"Suvarna SK, Layton C, Bancroft JD. Bancroft's Theory and Practice of Histological Techniques. 8th ed. Churchill Livingstone; 2018:83\u201392."},{"key":"B30","series-title":"Introduction to Immunocyto\u00adchemistry","first-page":"13","author":"Polak JM","year":"2003","unstructured":"Polak JM, Van Noorden S. Introduction to Immunocyto\u00adchemistry. 3rd ed. BIOS Scientific Publishers; 2003:13\u201381."},{"key":"B31","series-title":"Methods Toxicol","first-page":"334","article-title":"Methods for evaluation of rat epididymal sperm morphology","volume":"3","author":"Filler R","year":"1993","unstructured":"Filler R. Methods for evaluation of rat epididymal sperm morphology. Methods Toxicol. 1993;3:334\u2013343. doi:10.1016\/B978-0-12-461207-5.50025-0"},{"issue":"3","key":"B32","series-title":"Reprod Toxicol","first-page":"237","article-title":"Methods for assessing sperm motility, morphology, and counts in the rat, rabbit, and dog: a consensus report","volume":"10","author":"Seed J","year":"1996","unstructured":"Seed J, Chapin RE, Clegg ED, et al. Methods for assessing sperm motility, morphology, and counts in the rat, rabbit, and dog: a consensus report. Reprod Toxicol. 1996;10(3):237\u2013244. doi:10.1016\/0890-6238(96)00028-7"},{"issue":"3","key":"B33","series-title":"Urology","first-page":"545","article-title":"Antioxidative effect of royal jelly in cisplatin-induced testes damage","volume":"74","author":"Silici S","year":"2009","unstructured":"Silici S, Ekmekcioglu O, Eraslan G, Demirtas A. Antioxidative effect of royal jelly in cisplatin-induced testes damage. Urology. 2009;74(3):545\u2013551. doi:10.1016\/j.urology.2009.05.024"},{"issue":"2","key":"B34","series-title":"Mutat Res","first-page":"115","article-title":"Cisplatin disrupts mammalian spermatogenesis, but does not affect recombination or chromosome segregation","volume":"564","author":"Cherry SM","year":"2004","unstructured":"Cherry SM, Hunt PA, Hassold TJ. Cisplatin disrupts mammalian spermatogenesis, but does not affect recombination or chromosome segregation. Mutat Res. 2004;564(2):115\u2013128. doi:10.1016\/j.mrgentox.2004.08.010"},{"issue":"11","key":"B35","series-title":"J Biochem Mol Toxicol","first-page":"515","article-title":"Cisplatin-induced testicular toxicity in rats: the protective effect of arjunolic acid","volume":"28","author":"Sherif IO","year":"2014","unstructured":"Sherif IO, Abdel-Aziz A, Sarhan OM. Cisplatin-induced testicular toxicity in rats: the protective effect of arjunolic acid. J Biochem Mol Toxicol. 2014;28(11):515\u2013521. doi:10.1002\/jbt.21593"},{"issue":"5","key":"B36","series-title":"Urology","first-page":"1184.e1","article-title":"Selenium and lycopene attenuate cisplatin-induced testicular toxicity associated with oxidative stress in Wistar rats","volume":"79","author":"Salem EA","year":"2012","unstructured":"Salem EA, Salem NA, Maarouf AM, Serefoglu EC, Hellstrom WJG. Selenium and lycopene attenuate cisplatin-induced testicular toxicity associated with oxidative stress in Wistar rats. Urology. 2012;79(5):1184.e1\u20131184.e6. doi:10.1016\/j.urology.2011.12.006"},{"issue":"5","key":"B37","series-title":"J Androl","first-page":"505","article-title":"Chemoprotective effect of a nuclear factor-kappaB inhibitor, pyrrolidine dithiocarbamate, against cisplatin-induced testicular damage in rats","volume":"30","author":"Ilbey YO","year":"2009","unstructured":"Ilbey YO, Ozbek E, Simsek A, Cekmen M, Otunctemur A, Somay A. Chemoprotective effect of a nuclear factor-kappaB inhibitor, pyrrolidine dithiocarbamate, against cisplatin-induced testicular damage in rats. J Androl. 2009;30(5):505\u2013514. doi:10.2164\/jandrol.108.006270"},{"issue":"34","key":"B38","series-title":"J Natl Cancer Inst Monogr","first-page":"6","article-title":"Mechanisms of toxic damage to spermatogenesis","volume":"34","author":"Boekelheide K","year":"2005","unstructured":"Boekelheide K. Mechanisms of toxic damage to spermatogenesis. J Natl Cancer Inst Monogr. 2005;34(34):6\u20138. doi:10.1093\/jncimonographs\/lgi006"},{"issue":"5","key":"B39","series-title":"Endocrinology","first-page":"2398","article-title":"cis-platinum-mediated decrease in serum testosterone is associated with depression of luteinizing hormone receptors and cytochrome P-450scc in rat testis","volume":"126","author":"Maines MD","year":"1990","unstructured":"Maines MD, Sluss PM, Iscan M. cis-platinum-mediated decrease in serum testosterone is associated with depression of luteinizing hormone receptors and cytochrome P-450scc in rat testis. Endocrinology. 1990;126(5):2398\u20132406. doi:10.1210\/endo-126-5-2398"},{"issue":"2","key":"B40","series-title":"Asian J Androl","first-page":"291","article-title":"Herbal extracts counteract cisplatin-mediated cell death in rat testis","volume":"10","author":"Amin A","year":"2008","unstructured":"Amin A, Hamza AA, Kambal A, Daoud S. Herbal extracts counteract cisplatin-mediated cell death in rat testis. Asian J Androl. 2008;10(2):291\u2013297. doi:10.1111\/j.1745-7262.2008.00379.x"},{"issue":"3","key":"B41","series-title":"Toxicol Ind Health","first-page":"259","article-title":"Carbendazim-induced testicular damage and oxidative stress in albino rats: ameliorative effect of licorice aqueous extract","volume":"30","author":"Sakr SA","year":"2014","unstructured":"Sakr SA, Shalaby SY. Carbendazim-induced testicular damage and oxidative stress in albino rats: ameliorative effect of licorice aqueous extract. Toxicol Ind Health. 2014;30(3):259\u2013267. doi:10.1177\/0748233712456059"},{"issue":"2","key":"B42","series-title":"World J Mens Health","first-page":"249","article-title":"Protective effect of all-trans retinoic acid in cisplatin-induced testicular damage in rats","volume":"37","author":"Yucel C","year":"2019","unstructured":"Yucel C, Arslan FD, Ekmekci S, et al. Protective effect of all-trans retinoic acid in cisplatin-induced testicular damage in rats. World J Mens Health. 2019;37(2):249\u2013256. doi:10.5534\/wjmh.180105"}],"container-title":["American Journal of Veterinary Research"],"original-title":[],"link":[{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/ajvr\/86\/1\/ajvr.24.10.0288.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/ajvr\/86\/1\/ajvr.24.10.0288.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/ajvr\/86\/1\/ajvr.24.10.0288.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T13:09:09Z","timestamp":1735650549000},"score":1,"resource":{"primary":{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/ajvr\/86\/1\/ajvr.24.10.0288.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,1]]},"references-count":42,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.2460\/ajvr.24.10.0288","relation":{},"ISSN":["0002-9645","1943-5681"],"issn-type":[{"value":"0002-9645","type":"print"},{"value":"1943-5681","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,1]]}}}