{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T18:06:58Z","timestamp":1780942018092,"version":"3.54.1"},"reference-count":44,"publisher":"American Veterinary Medical Association (AVMA)","license":[{"start":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T00:00:00Z","timestamp":1749427200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2025,6,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec id=\"sc_a1\">\n<jats:title>Objective<\/jats:title>\n<jats:p>To evaluate the therapeutic potential of mesenchymal stem cells (MSCs) in alleviating carbon tetrachloride (CCl<jats:sub>4<\/jats:sub>)-induced liver damage in rats.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a2\">\n<jats:title>Methods<\/jats:title>\n<jats:p>The study was conducted from October 2024 through February 2025. A total of 80 rats (20 rats for MSC isolation and 60 additional rats) were divided into groups. The negative control groups received olive oil twice weekly for 9 weeks, a positive control group received CCl<jats:sub>4<\/jats:sub> in olive oil twice weekly for 9 weeks, and an MSC test group received the same treatment as the positive control group, followed by treatment with MSCs once a week for 4 weeks. Liver enzyme levels (ALT, ASP, and ALP) and the oxidant-antioxidant parameters (glutathione peroxidase, superoxide dismutase, malondialdehyde, glutathione peroxidase, catalase activity, and total antioxidant capacity) were assessed. Histopathological analysis of liver tissues was performed to examine the extent of liver damage.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a3\">\n<jats:title>Results<\/jats:title>\n<jats:p>The results showed increases in liver enzymes and oxidative stress markers in the positive control group compared to the negative control group. The MSC test group exhibited reduced liver enzyme levels, enhanced antioxidant activity, and improved histological findings, with reduced inflammation and fibrosis.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a4\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>MSCs possess a potent hepatoprotective effect through the restoration of antioxidant defenses, reduction of oxidative stress, and promotion of tissue regeneration.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a5\">\n<jats:title>Clinical Relevance<\/jats:title>\n<jats:p>This study supports the potential of MSC-based therapy as a promising approach for the treatment of liver damage caused by toxic insults, such as CCl<jats:sub>4<\/jats:sub>.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/ajvr.25.03.0074","type":"journal-article","created":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T14:23:40Z","timestamp":1749738220000},"page":"1-10","source":"Crossref","is-referenced-by-count":5,"title":["Hepatoprotective effects of mesenchymal stem cells in carbon tetrachloride\u2013induced liver toxicity in rats: restoration of liver parameters and histopathological evaluation"],"prefix":"10.2460","author":[{"given":"Ahmed","family":"Fotouh","sequence":"first","affiliation":[{"name":"Department of Pathology and Clinical Pathology, Faculty of Veterinary Medicine, New Valley University, El Kharga, Egypt"},{"name":"MBA Program, Department of Business Administration, Marywood University, Scranton, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nady Khairy","family":"Elbarbary","sequence":"additional","affiliation":[{"name":"Department of Food Hygiene and Control, Faculty of Veterinary Medicine, Aswan University, Aswan, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maha Abdullah","family":"Momenah","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohsen A.","family":"Khormi","sequence":"additional","affiliation":[{"name":"Biology Department, College of Science, Jazan University, Jazan, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wafaa H.","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Aswan University, Aswan, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoda S.","family":"Sherkawy","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Faculty of Medicine, Aswan University, Aswan, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed Ezzat","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Science, King Khalid University, Abha, Saudi Arabia"},{"name":"Prince Sultan Bin Abdelaziz for Environmental Research and Natural Resources Sustainability Center, King Khalid University, Abha, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Diab","sequence":"additional","affiliation":[{"name":"Department of Animal Hygiene and Zoonoses, Faculty of Veterinary Medicine, New Valley University, El Kharga, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Said","family":"Elshafae","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, College of Medicine, University of Utah, Salt Lake City, UT"},{"name":"Department of Pathology, Faculty of Veterinary Medicine, Benha University, Benha, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"issue":"4","key":"B1","series-title":"Transpl Direct","first-page":"e16","article-title":"Human amnion-derived mesenchymal stem cell transplantation ameliorates liver fibrosis in rats","volume":"1","author":"Kubo K","year":"2015","unstructured":"Kubo K, Ohnishi S, Hosono H, et al. 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