{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T15:24:58Z","timestamp":1762529098343,"version":"build-2065373602"},"reference-count":39,"publisher":"American Veterinary Medical Association (AVMA)","issue":"10","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2025,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"sc_a1\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the efficacy of a tooth-supported, 3-D\u2013printed, patient-specific reduction guide (TPSRG) in improving alignment accuracy, reducing surgical time, and minimizing structural breaches in simulated mandibular fractures in canine cadavers compared with a nonguided freehand technique.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a2\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This experimental ex vivo study involved 24 mandibles obtained from 12 skeletally mature canine cadavers without mandibular pathology. The experimental procedures were carried out from August 1, 2024, through February 1, 2025. Specimens were randomly assigned to either the guided or nonguided group. Mandibular fractures were simulated and stabilized with plate fixation and intraosseous wiring. Tooth-supported, 3-D\u2013printed, patient-specific reduction guides were individually designed using CT imaging and computer-aided design software based on the dental anatomy of each specimen. Surgical time was recorded to assess procedural efficiency. Postoperative CT scans were used to evaluate fracture alignment (rostrocaudal, dorsoventral, and mediolateral angulations), fracture gap volume, and the presence of breaches involving the mandibular canal or tooth roots.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a3\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Use of the TPSRG resulted in improved alignment in rostrocaudal and dorsoventral angulations and a smaller fracture gap compared to the nonguided group. Mediolateral alignment showed no difference. Surgical time was shorter in the TPSRG group. Structural breach rates did not differ between groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a4\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The TPSRG enhanced alignment accuracy and surgical efficiency in mandibular fracture repair using canine cadaver models, though it did not significantly reduce the incidence of structural breaches.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a5\">\n                    <jats:title>Clinical Relevance<\/jats:title>\n                    <jats:p>TPSRGs show promise as adjunctive tools to enhance precision and efficiency in the surgical management of simple mandibular fractures in dogs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2460\/ajvr.25.04.0122","type":"journal-article","created":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T17:38:44Z","timestamp":1752860324000},"source":"Crossref","is-referenced-by-count":0,"title":["Tooth-supported, 3-dimensionally printed reduction guide improves alignment and efficiency in simple mandibular fracture repair in dogs"],"prefix":"10.2460","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-2145-8037","authenticated-orcid":true,"given":"Kangwoo","family":"Yi","sequence":"first","affiliation":[{"name":"Department of Veterinary Surgery, College of Veterinary Medicine, Jeonbuk National University, Jeollabuk-do, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2458-7698","authenticated-orcid":true,"given":"Young","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Veterinary Surgery, College of Veterinary Medicine, Jeonbuk National University, Jeollabuk-do, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2160-1203","authenticated-orcid":true,"given":"Namsoo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Veterinary Surgery, College of Veterinary Medicine, Jeonbuk National University, Jeollabuk-do, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7733-3263","authenticated-orcid":true,"given":"Suyoung","family":"Heo","sequence":"additional","affiliation":[{"name":"Department of Veterinary Surgery, College of Veterinary Medicine, Jeonbuk National University, Jeollabuk-do, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"B1","series-title":"Handbook of Small Animal Orthopedics and Fracture Repair","first-page":"717","article-title":"Fractures and luxations of the mandible and maxilla","author":"Piermattei DL","year":"2006","unstructured":"Piermattei DL, Flo GL, DeCamp CE. Fractures and luxations of the mandible and maxilla. In: Handbook of Small Animal Orthopedics and Fracture Repair. 4th ed. Saunders-Elsevier; 2006:717\u2013736."},{"issue":"4","key":"B2","series-title":"Vet Surg","first-page":"272","article-title":"Mandibular fractures in the dog: a retrospective study of 157 cases","volume":"19","author":"Umphlet RC","year":"1990","unstructured":"Umphlet RC, Johnson AL. Mandibular fractures in the dog: a retrospective study of 157 cases. Vet Surg. 1990;19(4):272\u2013275. doi:10.1111\/j.1532-950x.1990.tb01184.x"},{"issue":"2","key":"B3","series-title":"Can Vet J","first-page":"143","article-title":"Partial mandibulectomy as the treatment of a comminuted mandibular fracture in a dog","volume":"42","author":"Hoelzler MG","year":"2001","unstructured":"Hoelzler MG, Holmberg DL. Partial mandibulectomy as the treatment of a comminuted mandibular fracture in a dog. Can Vet J. 2001;42(2):143\u2013144."},{"issue":"4","key":"B4","series-title":"Vet Surg","first-page":"567","article-title":"Mandibular body fracture repair with wire-reinforced interdental composite splint in small dogs","volume":"46","author":"Guzu M","year":"2017","unstructured":"Guzu M, Hennet PR. Mandibular body fracture repair with wire-reinforced interdental composite splint in small dogs. Vet Surg. 2017;46(4):567\u2013574. doi:10.1111\/vsu.12691"},{"issue":"23","key":"B5","series-title":"Vet Rec","first-page":"595","article-title":"The plating of mandibular fractures in the dog","volume":"88","author":"Sumner-Smith G","year":"1971","unstructured":"Sumner-Smith G, Dingwall JG. The plating of mandibular fractures in the dog. Vet Rec. 1971;88(23):595\u2013597. doi:10.1136\/vr.88.23.595"},{"issue":"6","key":"B6","series-title":"Vet Surg","first-page":"333","article-title":"Mandibular fractures in the cat: a retrospective study","volume":"17","author":"Umphlett RC","year":"1988","unstructured":"Umphlett RC, Johnson AL. Mandibular fractures in the cat: a retrospective study. Vet Surg. 1988;17(6):333\u2013337. doi:10.1111\/j.1532-950x.1988.tb01028.x"},{"key":"B7","series-title":"Oral and Maxillofacial Surgery in Dogs and Cats","first-page":"333","article-title":"Maxillofacial fracture complications","author":"Marretta SM","year":"2012","unstructured":"Marretta SM. Maxillofacial fracture complications. In: Verstraete FJM, Lommer MJ, eds. Oral and Maxillofacial Surgery in Dogs and Cats. Saunders-Elsevier; 2012:333\u2013341."},{"issue":"1","key":"B8","series-title":"Vet Comp Orthop Traumatol","first-page":"1","article-title":"A retrospective study of 109 dogs with mandibular fractures","volume":"26","author":"Kitshoff AM","year":"2013","unstructured":"Kitshoff AM, de Rooster H, Ferreira SM, Steenkamp G. A retrospective study of 109 dogs with mandibular fractures. Vet Comp Orthop Traumatol. 2013;26(1):1\u201310. doi:10.3415\/VCOT-12-01-0003"},{"issue":"8","key":"B9","series-title":"Can Vet J","first-page":"819","article-title":"Maxillary and mandibular fractures","volume":"49","author":"Harasen G","year":"2008","unstructured":"Harasen G. Maxillary and mandibular fractures. Can Vet J. 2008;49(8):819\u2013820."},{"issue":"4","key":"B10","series-title":"J Dent Res","first-page":"787","article-title":"Distributionoof cardiac output to oral tissues in dogs","volume":"49","author":"Meyer MW","year":"1970","unstructured":"Meyer MW. 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WB Saunders; 1985:2286\u20132295."},{"issue":"12","key":"B15","series-title":"Can Vet J","first-page":"1007","article-title":"Canine mandibular fracture repair using a technovit transfixation splint","volume":"29","author":"Kuzma AB","year":"1988","unstructured":"Kuzma AB, Cockshutt JR. Canine mandibular fracture repair using a technovit transfixation splint. Can Vet J. 1988;29(12):1007\u20131009."},{"key":"B16","series-title":"J Am Anim Hosp Assoc","first-page":"599","article-title":"Interarcade wiring as a method of fixation for selected mandibular injuries","volume":"17","author":"Lantz GC","year":"1981","unstructured":"Lantz GC. Interarcade wiring as a method of fixation for selected mandibular injuries. J Am Anim Hosp Assoc. 1981;17:599\u2013603."},{"key":"B17","series-title":"Vet Med Small AnimClin","first-page":"1029","article-title":"Emergency stabilisation of jaw fractures in a dog using acrylic splints","volume":"72","author":"Latimer KS","year":"1977","unstructured":"Latimer KS, Kemp WB, Taylor LA, Barton RA. Emergency stabilisation of jaw fractures in a dog using acrylic splints. Vet Med Small AnimClin. 1977;72:1029\u20131031."},{"issue":"11","key":"B18","series-title":"J Am Vet Med Assoc","first-page":"1590","article-title":"Biomechanical evaluation of acrylic external skeletal fixation in dogs and cats","volume":"199","author":"Okranski E","year":"1991","unstructured":"Okranski E, Pardo A, Graehler R. Biomechanical evaluation of acrylic external skeletal fixation in dogs and cats. 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