{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:40:41Z","timestamp":1787503241732,"version":"build-2736575974"},"reference-count":46,"publisher":"American Veterinary Medical Association (AVMA)","issue":"11","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2025,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"sc_a1\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To characterize classical and alternative circulating renin-angiotensin-aldosterone system (RAAS) activities in cats with chronic kidney disease (CKD) induced by 11\/12th functional nephrectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a2\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a prospective study performed from September 9, 2022, through August 16, 2023. Serum was collected at 2 time points 6 months apart from young-adult purpose-bred cats with remnant kidney model\u2013induced CKD (n = 15; 6 hypertensive, chronically treated with amlodipine besylate) and at a single time point from young-adult community-owned healthy cats (n = 15). Equilibrium concentrations of angiotensin I, II, III, IV, 1\u20135, and 1\u20137 and aldosterone as well as angiotensin-converting enzyme 2 activity were measured using LC-MS\/MS. Kidney function was assessed 10 months after baseline RAAS evaluation in amenable CKD cats (n = 12) to identify progression (ie, 25% increase in serum concentration[s] of creatinine, symmetric dimethylarginine, or both). Linear mixed models were used for intergroup comparisons, accounting for blood pressure and amlodipine therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a3\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Serum aldosterone concentrations were higher in the CKD group than the healthy group; however, no angiotensin peptide concentrations differed significantly between groups. Amlodipine-treated CKD cats had higher concentrations of all RAAS markers than their nonhypertensive, amlodipine-na\u00efve counterparts. Concentrations of RAAS markers at baseline in cats that experienced CKD progression (n = 3) were among the lowest of all CKD cats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a4\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Evidence of RAAS activation at the level of circulating angiotensin peptides was not found in cats with induced CKD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a5\">\n                    <jats:title>Clinical Relevance<\/jats:title>\n                    <jats:p>Although circulating aldosterone was increased in cats with induced CKD, this was not likely driven by an increase in other circulating RAAS components.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2460\/ajvr.25.06.0201","type":"journal-article","created":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T12:42:57Z","timestamp":1755175377000},"source":"Crossref","is-referenced-by-count":2,"title":["Classical and alternative renin-angiotensin-aldosterone systems in a feline remnant kidney model"],"prefix":"10.2460","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-4528-9245","authenticated-orcid":true,"given":"Jane H. 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