{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T14:10:03Z","timestamp":1767363003406,"version":"3.48.0"},"reference-count":38,"publisher":"American Veterinary Medical Association (AVMA)","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2026,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"sc_a1\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To report serological identification of Cache Valley virus (CVV) in ewes from Auburn, Alabama.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a2\">\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>6 ewes and 1 ram from the teaching flock at Auburn University College of Veterinary Medicine were tested for CVV via virus neutralization. From October through November 2024, 3 ewes underwent Cesarean sections, with 2 lambs delivered from each ewe. Severe musculoskeletal deformities in 3 of the 6 lambs, delivered from 2 of the ewes that underwent Cesarean sections, prompted investigation into a causative agent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a3\">\n                    <jats:title>Clinical Presentation<\/jats:title>\n                    <jats:p>3 of the 6 lambs were clinically normal, but 3 of the lambs demonstrated severe arthrogryposis, kyphosis, and scoliosis and were humanely euthanized. Upon necropsy, affected lambs had severe internal hydrocephalus with severe cerebellar hypoplasia and marked atrophy of the spinal cord.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a4\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 7 sheep in the teaching flock, all 6 ewes tested positive for CVV titers via virus neutralization, whereas the ram tested negative. Two ewes had deformed lambs, 1 had normal lambs, and the other 3 were open following a controlled breeding period with the ram. All ewes and the ram remained healthy throughout breeding and lambing, and the 3 unaffected lambs were raised to weaning normally.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a5\">\n                    <jats:title>Clinical Relevance<\/jats:title>\n                    <jats:p>This case series documents the spread of CVV in the US and highlights the validity of testing for CVV in flocks experiencing characteristic congenital malformations. Veterinarians must consider CVV as a differential even in previously nonendemic regions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2460\/ajvr.25.06.0213","type":"journal-article","created":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T12:29:24Z","timestamp":1759321764000},"source":"Crossref","is-referenced-by-count":0,"title":["Cache Valley virus serologically identified in sheep with congenitally malformed lambs in Alabama"],"prefix":"10.2460","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-2760-8345","authenticated-orcid":true,"given":"Hannah E.","family":"Maxwell","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, AL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5874-4639","authenticated-orcid":true,"given":"Dane W.","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, AL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5616-6953","authenticated-orcid":true,"given":"Alyona","family":"Michael","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katelyn","family":"Waters","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, AL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica B.","family":"Rush","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, AL"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"issue":"3","key":"B1","series-title":"J Vet Diagn Invest","first-page":"265","article-title":"Causes of caprine abortion: diagnostic assessment of 211 cases (1991\u20131998)","volume":"13","author":"Moeller RB","year":"2001","unstructured":"Moeller RB. 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