{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T14:10:03Z","timestamp":1767363003297,"version":"3.48.0"},"reference-count":56,"publisher":"American Veterinary Medical Association (AVMA)","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2026,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"sc_a1\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the diagnostic utility of 2 point-of-care cryptococcal antigen (CrAg) lateral flow assays (LFAs; Dynamiker Biotechnology Co Ltd and IMMY) for the diagnosis of cryptococcosis in dogs and cats using a latex CrAg agglutination test (Cryptococcal Antigen Latex Agglutination System; Meridian Bioscience) as the reference standard.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a2\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Serum samples from 21 dogs and cats considered to be infected with cryptococcus and 30 animals considered unlikely to be infected were assayed using both point-of-care LFAs from January 2024 through April 2025, and sensitivity and specificity estimates were calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a3\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The CrAg LFA (IMMY) had an estimated sensitivity of 95% (95% CI, 76.0% to 100%) and an estimated specificity of 100% (95% CI, 88.0% to 100%). The CrAg LFA (Dynamiker Biotechnology Co Ltd) had an estimated sensitivity of 100% (95% CI, 83.0% to 100%) and specificity of 20% (95% CI, 8.00% to 39.0%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a4\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The CrAg LFA (IMMY) is unequivocally superior to the CrAg LFA (Dynamiker Biotechnology Co Ltd) for the screening of cryptococcosis in dogs and cats due to its vastly superior specificity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a5\">\n                    <jats:title>Clinical Relevance<\/jats:title>\n                    <jats:p>The CrAg LFA (Dynamiker Biotechnology Co Ltd) in its present form should not be considered as a useful test to screen cats and dogs for cryptococcosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2460\/ajvr.25.06.0227","type":"journal-article","created":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:42:08Z","timestamp":1759945328000},"source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic performance of lateral flow antigen tests versus latex agglutination for cryptococcosis in dogs and cats"],"prefix":"10.2460","volume":"87","author":[{"given":"Samantha A.","family":"Wong","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Veterinary Specialist Services, Underwood, QLD, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8926-5942","authenticated-orcid":true,"given":"John","family":"Morton","sequence":"additional","affiliation":[{"name":"Jemora Pty Ltd, East Geelong, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luisa","family":"Monteiro de Miranda","sequence":"additional","affiliation":[{"name":"Veterinary Pathology Diagnostic Services, Sydney School of Veterinary Science, The University of Sydney, Sydney, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark B.","family":"Krockenberger","sequence":"additional","affiliation":[{"name":"Veterinary Pathology Diagnostic Services, Sydney School of Veterinary Science, The University of Sydney, Sydney, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elissa","family":"Shinozaki","sequence":"additional","affiliation":[{"name":"Veterinary Pathology Diagnostic Services, Sydney School of Veterinary Science, The University of Sydney, Sydney, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Malik","sequence":"additional","affiliation":[{"name":"Centre for Veterinary Education, Sydney School of Veterinary Science, Veterinary Science Conference Centre, The University of Sydney, Sydney, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"issue":"3","key":"B1","series-title":"J Am Vet Med Assoc","first-page":"357","article-title":"Clinical features and epidemiology of cryptococcosis in cats and dogs in California: 93 cases (1988\u20132010)","volume":"239","author":"Trivedi SR","year":"2011","unstructured":"Trivedi SR, Sykes JE, Cannon MS, et al. 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