{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T18:36:33Z","timestamp":1788633393916,"version":"build-2803163510"},"reference-count":39,"publisher":"American Veterinary Medical Association (AVMA)","issue":"12","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2025,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"sc_a1\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine initial antibody titer, degradation profile, and duration of passive antibody blockade of active immunization by modified-live viral (MLV) canine parvovirus (CPV-2) vaccine following CPV monoclonal antibody (CPMA) prophylactic subcutaneous (SC) administration to CPV-2\u2013na\u00efve puppies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a2\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Purpose-bred, CPV-2\u2013seronegative male and female Beagle dogs, 7 to 8 weeks of age, were randomized to CPMA treatment (n = 13) and control (7) groups. Dogs were commingled and group housed in a shower-in\/shower-out facility. At study day 0, dogs were administered either 0.1 mL\/kg body weight CPMA SC or an equivalent volume of saline. Sera collected weekly over 140 days were assayed via hemagglutination inhibition and serum virus neutralization. All dogs were administered a commercially available MLV vaccine containing CPV-2 in combination with other core vaccine viruses at 3-week time points beginning at study day 42.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a3\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      All control dogs remained seronegative through day 42 and seroconverted to CPV-2 after the initial dose of MLV vaccine. By study day 1, the CPMA-treated group showed a mean passive hemagglutination inhibition titer of 1,674. The average degradation rate was calculated at\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      = 0.97, with a mean half-life of 18.9 days. Twelve of 13 (92%) in the treated group seroconverted after a fourth vaccination on day 105.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a4\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Prophylactic CPMA at 0.1 mL\/kg body weight SC can block active CPV-2 immunization for 15 weeks when given to seronegative puppies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a5\">\n                    <jats:title>Clinical Relevance<\/jats:title>\n                    <jats:p>Initial puppy vaccination series should be extended after CPMA prophylactic use.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2460\/ajvr.25.07.0233","type":"journal-article","created":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T12:43:24Z","timestamp":1758890604000},"source":"Crossref","is-referenced-by-count":1,"title":["Prophylactic use of canine parvovirus monoclonal antibody induces blockade of vaccinal canine parvovirus immunization similar to maternally derived passive immunity"],"prefix":"10.2460","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6521-2811","authenticated-orcid":true,"given":"Laurie","family":"Larson","sequence":"first","affiliation":[{"name":"Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Hansen","sequence":"additional","affiliation":[{"name":"Elanco Animal Health, Greenfield, IN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prakash","family":"Ramasami","sequence":"additional","affiliation":[{"name":"Elanco Animal Health, Greenfield, IN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer M.","family":"Miller","sequence":"additional","affiliation":[{"name":"Elanco Animal Health, Greenfield, IN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barton J.","family":"Slagter","sequence":"additional","affiliation":[{"name":"Elanco Animal Health, Greenfield, IN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Tremblay","sequence":"additional","affiliation":[{"name":"Elanco Animal Health, Greenfield, IN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayur","family":"Patel","sequence":"additional","affiliation":[{"name":"Elanco Animal Health, Greenfield, IN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terri","family":"Wasmoen","sequence":"additional","affiliation":[{"name":"ACI Biosciences, Chevy Chase, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"B1","series-title":"Greene's Infectious Diseases of the Dog and Cat","first-page":"341","article-title":"Canine parvovirus infections and other viral enteritides","author":"Parrish CR","year":"2023","unstructured":"Parrish CR, Sykes JE. 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