{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T15:07:17Z","timestamp":1772464037835,"version":"3.50.1"},"reference-count":56,"publisher":"American Veterinary Medical Association (AVMA)","issue":"3","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2026,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"sc_a1\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine the effect of phenylpropanolamine (PPA; Proin) on intraocular pressure (IOP) and Schirmer tear test\u2013I (STT-I) values in dogs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a2\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Following baseline ophthalmic examinations, including IOP and STT-I measurements, 6 healthy, purpose-bred intact female Beagles aged 7.5 to 10 months were orally administered PPA at 2 mg\/kg twice daily over a 4-week period. Intraocular pressure was measured twice weekly at 8:00\n                      <jats:sc>am<\/jats:sc>\n                      , 12:00\n                      <jats:sc>pm<\/jats:sc>\n                      , and 4:00\n                      <jats:sc>pm<\/jats:sc>\n                      . Schirmer tear test\u2013I was measured once weekly. A complete ophthalmic examination was conducted every 2 weeks. Intraocular pressure measurement continued once weekly for a 2-month period following discontinuation of PPA. Descriptive data are presented as mean \u00b1 SE of the mean.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a3\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared with pretreatment IOPs (20.8 \u00b1 0.5 mm Hg), values showed a statistically significant increase (23.0 \u00b1 0.3 mm Hg and 21.9 \u00b1 0.3 mm Hg during and after administration, respectively), whereas STT-I values in the right eye showed a statistically significant decrease during PPA administration. Although none of these changes were clinically relevant, dogs with high baseline IOPs exhibited greater fluctuation with elevated IOPs following PPA administration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a4\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PPA administration induced an increase in IOP and exacerbated IOP fluctuation in dogs with high baseline IOP. Phenylpropanolamine should be prescribed with caution in patients with elevated baseline IOP or those predisposed to glaucoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a5\">\n                    <jats:title>Clinical Relevance<\/jats:title>\n                    <jats:p>These findings highlight the importance of monitoring IOP in dogs receiving PPA, particularly those with ocular hypertension or a predisposition to glaucoma, to ensure safe clinical use.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2460\/ajvr.25.08.0284","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T16:52:44Z","timestamp":1765385564000},"source":"Crossref","is-referenced-by-count":0,"title":["Phenylpropanolamine (Proin) increases intraocular pressure and alters tear production in dogs"],"prefix":"10.2460","volume":"87","author":[{"given":"Sunjun","family":"Jung","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN"},{"name":"Department of Veterinary Ophthalmology, College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keely","family":"Harris","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyerim","family":"Ra","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie Zhi-Ying","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Hoard","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oluwabunmi","family":"Oladele","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brenna","family":"Janowski","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Levi H.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsin-Yi","family":"Weng","sequence":"additional","affiliation":[{"name":"Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, IN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin Ae","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"issue":"2","key":"B1","series-title":"Neurology","first-page":"146","article-title":"Phenylpropanolamine contained in cold remedies and risk of hemorrhagic stroke","volume":"68","author":"Yoon B","year":"2007","unstructured":"Yoon B, Bae H, Hong K, et al. 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