{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T15:06:49Z","timestamp":1772464009381,"version":"3.50.1"},"reference-count":82,"publisher":"American Veterinary Medical Association (AVMA)","issue":"3","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2026,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"sc_a1\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To develop and validate an owner-reported health-related quality-of-life (HRQoL) questionnaire in cats with chronic kidney disease (CKD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a2\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a noninterventional, international study. Initial draft items were identified through qualitative literature and social media reviews. Concept elicitation and cognitive debriefing interviews were conducted with owners of cats with International Renal Interest Society\u2013staged CKD in the US and United Kingdom to further inform item development. A 2\u2013time point observational study was then conducted in a Greek sample of owners of cats with stable CKD to allow for psychometric analysis. Expert veterinarian input was incorporated throughout. Participants were recruited using purposive convenience sampling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a3\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Owners of 10 cats participated in interviews, and owners of 208 cats were included in the psychometric evaluation. An initial 20-item questionnaire was debriefed and refined across 2 rounds of interviews, resulting in a 21-item version for psychometric evaluation. The final questionnaire comprised 13 items assessing observable HRQoL impacts of feline CKD. Psychometric analyses confirmed a unidimensional structure, with high internal consistency (Cronbach \u03b1 coefficient = 0.92; McDonald \u03c9 coefficient = 0.93), moderate to good test-retest reliability (\u2265 0.72), and strong convergent validity. Questionnaire responses discriminated between early and late International Renal Interest Society stages and varying levels of overall HRQoL as reported by owners and veterinarians.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a4\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This research presents a novel, disease-specific, psychometrically validated questionnaire assessing HRQoL in feline CKD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a5\">\n                    <jats:title>Clinical Relevance<\/jats:title>\n                    <jats:p>The questionnaire is fit for purpose for use in feline CKD both in clinical trials and veterinary practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2460\/ajvr.25.08.0293","type":"journal-article","created":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T20:34:23Z","timestamp":1765485263000},"source":"Crossref","is-referenced-by-count":0,"title":["The new Health-Related Quality of Life in Feline Chronic Kidney Disease Questionnaire demonstrates reliability and validity for use in feline clinical trials"],"prefix":"10.2460","volume":"87","author":[{"given":"Andrea","family":"Wright","sequence":"first","affiliation":[{"name":"Zoetis Incorporated, Parsippany, NJ"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chloe","family":"Howse","sequence":"additional","affiliation":[{"name":"Patient-Centered Outcomes, Adelphi Values Ltd, Bollington, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7115-0394","authenticated-orcid":true,"given":"George","family":"Skingley","sequence":"additional","affiliation":[{"name":"Patient-Centered Outcomes, Adelphi Values Ltd, Bollington, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Valiakos","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, University of Thessaly, Thessaly, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioulia","family":"Chortara","sequence":"additional","affiliation":[{"name":"Asclepius One Health, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Nabity","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4517-6590","authenticated-orcid":true,"given":"Jonathan","family":"Elliott","sequence":"additional","affiliation":[{"name":"Department of Comparative Biomedical Sciences, The Royal Veterinary College, University of London, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6039-5241","authenticated-orcid":true,"given":"Thaisa Lucas","family":"Sandri","sequence":"additional","affiliation":[{"name":"Zoetis Incorporated, Parsippany, NJ"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Stochl","sequence":"additional","affiliation":[{"name":"Patient-Centered Outcomes, Adelphi Values Ltd, Bollington, United Kingdom"},{"name":"Department of Kinanthropology, Charles University, Prague, Czechia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1167-7693","authenticated-orcid":true,"given":"Aoife","family":"Mahon-Smith","sequence":"additional","affiliation":[{"name":"Patient-Centered Outcomes, Adelphi Values Ltd, Bollington, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"issue":"1","key":"B1","series-title":"Vet Clin North Am Small Anim Pract","first-page":"15","article-title":"Chronic kidney disease in small animals","volume":"41","author":"Polzin DJ","year":"2011","unstructured":"Polzin DJ. 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Principles of good practice for the translation and cultural adaptation process for patient-reported outcomes (PRO) measures: report of the ISPOR task force for translation and cultural adaptation. Value Health. 2005;8(2):94\u2013104. doi:10.1111\/j.1524-4733.2005.04054.x"},{"key":"B30","article-title":"Guidance for industry: patient-reported outcome measures: use in medical product development to support labeling claims: draft guidance","unstructured":"US Department of Health Human Services FDA Center for Drug Evaluation and Research, US Department of Health Human Services FDA Center for Biologics Evaluation and Research, US Department of Health Human Services FDA Center for Devices and Radiological Health. Guidance for industry: patient-reported outcome measures: use in medical product development to support labeling claims: draft guidance. 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