{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T15:05:33Z","timestamp":1772463933435,"version":"3.50.1"},"reference-count":66,"publisher":"American Veterinary Medical Association (AVMA)","issue":"3","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2026,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"sc_a1\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To describe the clinical effects of photobiomodulation (PBM) therapy using a dual-wavelength near-infrared laser (Multiwave Locked System; Asa Srl) as adjunctive treatment in dogs with calcinosis cutis (CC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a2\">\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>\n                      3 client-owned dogs presented to 2 referral veterinary hospitals from 2022 through 2023 were included. Cases were identified retrospectively via medical record review. Inclusion criteria were clinical and cytological features consistent with CC and histopathological examination when available, diagnosis of hyperadrenocorticism (HAC) based on clinical signs and diagnostic workup, availability of sufficient clinical records and photographic documentation, and owner consent for PBM therapy. Photobiomodulation was applied following a standardized protocol in scanning mode with a 2-cm collimated handpiece (approx 3-cm\n                      <jats:sup>2<\/jats:sup>\n                      spot): 3 sessions during week 1, every 72 hours in week 2, and then weekly with 4 J\/cm\n                      <jats:sup>2<\/jats:sup>\n                      at the first session and 2.03 J\/cm\n                      <jats:sup>2<\/jats:sup>\n                      thereafter.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a3\">\n                    <jats:title>Clinical Presentation<\/jats:title>\n                    <jats:p>Included dogs were a 5-year-old male Labrador Retriever and an 8-year-old male English Bulldog with naturally occurring HAC and a 3-year-old female German Shepherd with iatrogenic HAC. All presented with dermatologic lesions compatible with CC (erythematous-crusted plaques, erosive-ulcerative lesions, and\/or papules).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a4\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>2 dogs achieved complete lesion resolution with hair regrowth within 7 to 12 weeks; the third showed partial improvement. No adverse events occurred.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a5\">\n                    <jats:title>Clinical Relevance<\/jats:title>\n                    <jats:p>Findings, although based on a limited number of cases, suggest a potential supportive role for PBM in the management of CC. Controlled studies are warranted to establish standardized treatment parameters and clarify its role in CC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2460\/ajvr.25.09.0314","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T14:49:30Z","timestamp":1763650170000},"source":"Crossref","is-referenced-by-count":0,"title":["Effectiveness of Multiwavelength Locked System laser therapy for calcinosis cutis in 3 dogs: a case series"],"prefix":"10.2460","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-4253-1494","authenticated-orcid":true,"given":"Federica","family":"Gesuete","sequence":"first","affiliation":[{"name":"Department of Dermatology, Anicura Istituto Veterinario di Novara, SP9, Granozzo con Monticello, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filippo","family":"Ferri","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Anicura Istituto Veterinario di Novara, SP9, Granozzo con Monticello, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Mu\u00f1oz Declara","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Anicura Istituto Veterinario di Novara, SP9, Granozzo con Monticello, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5294-5116","authenticated-orcid":true,"given":"Luca","family":"Luciani","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Anicura Ospedale Veterinario I Portoni Rossi, Via Roma, 57\/A, Zola Predosa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Tirrito","sequence":"additional","affiliation":[{"name":"Department of Neurology, Anicura Istituto Veterinario di Novara, Granozzo con Monticello, Italy"},{"name":"University of Bari \u201cAldo Moro\u201d, Strada provinciale per Casamassima Km 3, Valenzano, Italy"},{"name":"Universit\u00e0 degli Studi di Milano, Via dell\u2019Universit\u00e0 6, Lodi, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giordana","family":"Zanna","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Anicura Istituto Veterinario di Novara, SP9, Granozzo con Monticello, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"B1","series-title":"Skin Diseases of the Dog and Cat: Clinical and Histopathologic Diagnosis","first-page":"373","article-title":"Degenerative, dysplastic and depositional diseases of dermal connective tissue","author":"Gross TL","year":"2005","unstructured":"Gross TL, Ihrke PJ. 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