{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T13:12:33Z","timestamp":1784293953517,"version":"3.55.0"},"reference-count":56,"publisher":"American Veterinary Medical Association (AVMA)","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2026,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"sc_a1\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To evaluate the impact of anesthesia and body temperature changes on a point-of-care viscoelastic coagulation monitoring device (VCM-Vet, Entegrion Corp) parameters in New Zealand white rabbits (\n                      <jats:italic>Oryctolagus cuniculus<\/jats:italic>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a2\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Purpose-bred New Zealand white rabbits were anesthetized in a research facility as part of a randomized, complete crossover study. Each rabbit was anesthetized using isoflurane twice (7 days apart), with or without a heated anesthesia circuit (Heated ZDS Qube; Darvall), over approximately 2 weeks. Lateral saphenous venipuncture was performed within 5 minutes of anesthetic induction (baseline) and at 50 minutes after anesthetic induction (T\n                      <jats:sub>50<\/jats:sub>\n                      ) during each event. Fresh whole blood was immediately tested using a single VCM-Vet analyzer, providing 2 tracings per event. Statistical analysis was performed using a linear mixed model with significance at\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a3\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      10 approximately 4-month-old intact male apparently healthy rabbits were included. All rabbits were normothermic (median, 39.3\u2009\u00b0C; range, 38.5 to 39.8\u2009\u00b0C) at baseline, and all rectal temperatures were lower at T\n                      <jats:sub>50<\/jats:sub>\n                      compared to baseline (median, 1.6\u2009\u00b0C; range, 0.7 to 2.1\u2009\u00b0C). There was no statistically significant difference in any clot parameter between baseline and T\n                      <jats:sub>50<\/jats:sub>\n                      nor between different rectal temperatures; however, there were statistical differences in 4 clot parameters between nonheated and heated anesthetic events.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a4\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Anesthesia and mildly decreased body temperature did not significantly impact the viscoelastography assessment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a5\">\n                    <jats:title>Clinical Relevance<\/jats:title>\n                    <jats:p>Although thromboelastography reference intervals have been established in rabbits, the use of the VCM-Vet analyzer is understudied in this species. Future research is needed to determine VCM-Vet reference intervals for rabbits.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2460\/ajvr.25.09.0317","type":"journal-article","created":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T16:34:31Z","timestamp":1767112471000},"source":"Crossref","is-referenced-by-count":1,"title":["Isoflurane anesthesia and body temperature changes do not significantly affect Viscoelastic Coagulation Monitor Vet viscoelastography of New Zealand white rabbits (Oryctolagus cuniculus)"],"prefix":"10.2460","volume":"87","author":[{"given":"Greta","family":"Doden","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daneeya","family":"Guthrie","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pratyaydipta","family":"Rudra","sequence":"additional","affiliation":[{"name":"Department of Statistics, College of Arts and Sciences, Oklahoma State University, Stillwater, OK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julianne E.","family":"McCready","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o","family":"Brand\u00e3o","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"issue":"3","key":"B1","series-title":"Vet Clin North Am Exot Anim Pract","first-page":"597","article-title":"Viscoelastic coagulation testing in exotic animals","author":"Cummings CO","year":"2022","unstructured":"Cummings CO, Eisenbarth J, de Laforcade A. Viscoelastic coagulation testing in exotic animals. Vet Clin North Am Exot Anim Pract. 2022;25(3):597\u2013612. doi:10.1016\/j.cvex.2022.06.001"},{"issue":"4","key":"B2","series-title":"Vet Clin Pathol","first-page":"567","article-title":"Establishment of normal reference intervals in dogs using a viscoelastic point-of-care coagulation monitor and its comparison with thromboelastography","author":"Buriko Y","year":"2020","unstructured":"Buriko Y, Drobatz K, Silverstein DC. Establishment of normal reference intervals in dogs using a viscoelastic point-of-care coagulation monitor and its comparison with thromboelastography. 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