{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T15:06:10Z","timestamp":1772463970701,"version":"3.50.1"},"reference-count":72,"publisher":"American Veterinary Medical Association (AVMA)","issue":"3","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2026,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"sc_a1\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To evaluate whether adding vatinoxan to an \u03b1\n                      <jats:sub>2<\/jats:sub>\n                      -adrenoceptor agonist\u2013based anesthetic protocol would attenuate cardiovascular depression or influence anesthetic depth in white-tailed deer (\n                      <jats:italic>Odocoileus virginianus<\/jats:italic>\n                      ) anesthetized with medetomidine and tiletamine\/zolazepam.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a2\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In a masked crossover design, 9 healthy adult female white-tailed deer were anesthetized from February 24 through March 14, 2025, with IM medetomidine (0.075 mg\/kg) and tiletamine\/zolazepam (4 mg\/kg). Once anesthetized and monitored, each deer received either IM vatinoxan (1.5 mg\/kg) or an equivalent volume of saline solution. Subjects were monitored for 45 minutes after treatment administration, after which anesthesia was reversed with IM atipamezole (0.35 mg\/kg). Vital signs, serial arterial blood gas values, sedation score, and recovery scores were analyzed for significant differences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a3\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Vatinoxan administration resulted in significantly higher heart rates and lower mean arterial pressure, rectal temperature, and PaCO\n                      <jats:sub>2<\/jats:sub>\n                      . Hypotension was noted in 1 animal following vatinoxan administration. No significant differences were found in oxygen saturation, sedation scores, recovery times, or the total amount of additional anesthetic supplementation required.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a4\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Vatinoxan provided cardiac-sparing effects in white-tailed deer without compromising anesthetic depth. Further studies are warranted to investigate its impact on tissue perfusion in the absence of oxygen supplementation and to determine the minimum effective dose in this setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a5\">\n                    <jats:title>Clinical Relevance<\/jats:title>\n                    <jats:p>Vatinoxan, administered IM at 20 times the medetomidine dose, may be considered as an adjunct to medetomidine-tiletamine-zolazepam anesthetic protocols for short procedures to mitigate peripheral vasoconstriction and bradycardia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2460\/ajvr.25.09.0340","type":"journal-article","created":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T13:28:10Z","timestamp":1764854890000},"source":"Crossref","is-referenced-by-count":0,"title":["Vatinoxan reduces hypertension and bradycardia without compromising anesthesia quality in medetomidine-anesthetized white-tailed deer: a randomized trial"],"prefix":"10.2460","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6112-2308","authenticated-orcid":true,"given":"Megan M.","family":"Gremling","sequence":"first","affiliation":[{"name":"Department of Large Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens, GA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Barletta","sequence":"additional","affiliation":[{"name":"Department of Large Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens, GA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Camlic","sequence":"additional","affiliation":[{"name":"Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Sallaberry-Pincheira","sequence":"additional","affiliation":[{"name":"Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA"},{"name":"Unidad de Rehabilitacion de Fauna Silvestre, Escuela de Medicina Veterinaria, Facultad de Ciencias de La Vida, Universidad Andres Bello, Santiago, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jarred M.","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Large Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens, GA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen J.","family":"Divers","sequence":"additional","affiliation":[{"name":"Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gino J.","family":"D'Angelo","sequence":"additional","affiliation":[{"name":"Warnell School of Forestry and Natural Resources, University of Georgia, Athens, GA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"B1","series-title":"Zoo Animal and Wildlife Immobilization and Anesthesia","first-page":"1081","article-title":"Deer","author":"Caulkett N","year":"2025","unstructured":"Caulkett N, Arnemo JM. 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