{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T16:03:08Z","timestamp":1785513788208,"version":"3.56.0"},"reference-count":18,"publisher":"American Veterinary Medical Association (AVMA)","issue":"8","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2026,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"sc_a1\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Investigate effect of hyperbaric oxygen therapy (HBOT) on recovery of deep pain perception (DPP) in dogs after hemilaminectomy for thoracolumbar intervertebral disk disease (IVDD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a2\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Records of client-owned dogs with absent DPP in pelvic limbs after hemilaminectomy for IVDD from January 2014 through December 2024 were retrospectively reviewed. Dogs undergoing hemilaminectomy were divided into groups: received HBOT (HB) and no HBOT (NHB). Modified Frankel scores were assigned between 0 (absent DPP in either pelvic limb) and 5 (spinal hyperesthesia) preoperatively, postoperatively, and at recheck examination. Outcomes were compared using the Pearson \u03c7\n                      <jats:sup>2<\/jats:sup>\n                      test. Regression analysis assessed if other factors were associated with improvement in Frankel score.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a3\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      110 dogs with absent DPP had thoracolumbar hemilaminectomies, 45 in HB group and 65 in NHB group. Thirty-three of 45 HB cases (73.3%) and 39 of 65 NHB cases (60%) improved neurologically by recheck examination (\n                      <jats:italic>P<\/jats:italic>\n                      = .21). There were no differences in neurological improvement between groups at any time point (\n                      <jats:italic>P<\/jats:italic>\n                      = .32). Multivariable regression analysis revealed worse odds of improvement for thoracolumbar relative to lumbar lesions (OR, 0.01; 95% CI, 0.0008 to 0.49;\n                      <jats:italic>P<\/jats:italic>\n                      = .04). Improvement odds with thoracolumbar lesions were lower in NHB than HB group (contrast OR, 0.029; 95% CI, 0.027 to 0.031;\n                      <jats:italic>P<\/jats:italic>\n                      = .01). HBOT session amount was not associated with improvement (\n                      <jats:italic>P<\/jats:italic>\n                      = .65).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a4\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>HBOT did not impact recovery of DPP after hemilaminectomy. Thoracolumbar lesions had lower odds of neurological improvement than lumbar lesions. Odds were improved with HBOT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a5\">\n                    <jats:title>Clinical Relevance<\/jats:title>\n                    <jats:p>Findings may predict return to ambulation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2460\/ajvr.26.01.0009","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T13:38:58Z","timestamp":1778074738000},"source":"Crossref","is-referenced-by-count":0,"title":["Hyperbaric oxygen therapy does not improve recovery of deep pain perception in dogs after hemilaminectomy for intervertebral disk disease"],"prefix":"10.2460","volume":"87","author":[{"given":"Leah T.","family":"Kienitz","sequence":"first","affiliation":[{"name":"Department of Surgery, Veterinary Specialty Center, Bannockburn, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4088-6902","authenticated-orcid":true,"given":"Annette M.","family":"McCoy","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Medicine, University of Illinois Urbana-Champaign, College of Veterinary Medicine, Urbana, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell A.","family":"Robbins","sequence":"additional","affiliation":[{"name":"Department of Surgery, Veterinary Specialty Center, Bannockburn, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"issue":"12","key":"B1","series-title":"J Am Vet Med Assoc","first-page":"1617","article-title":"Long-term neurologic outcome of hemilaminectomy and disk fenestration for treatment of dogs with thoracolumbar intervertebral disk herniation: 831 cases (2000-2007)","author":"Aikawa T","year":"2012","unstructured":"Aikawa T, Fujita H, Kanazono S, Shibata M, Yoshigae Y. Long-term neurologic outcome of hemilaminectomy and disk fenestration for treatment of dogs with thoracolumbar intervertebral disk herniation: 831 cases (2000-2007). J Am Vet Med Assoc. 2012;241(12):1617\u20131626. doi:10.2460\/javma.241.12.1617"},{"issue":"1","key":"B2","series-title":"Vet Rec Open","first-page":"e61","article-title":"A case series of 37 surgically managed, paraplegic, deep pain negative French Bulldogs, with thoracolumbar intervertebral disc extrusion, from two English referral centres","author":"Jones GMC","year":"2023","unstructured":"Jones GMC, Cherubini GB, Llabres-Diaz F, Caine A, De Stefani A. A case series of 37 surgically managed, paraplegic, deep pain negative French Bulldogs, with thoracolumbar intervertebral disc extrusion, from two English referral centres. Vet Rec Open. 2023;10(1):e61. doi:10.1002\/vro2.61"},{"key":"B3","series-title":"Front. Vet. Sci","first-page":"596059","article-title":"Prognostic factors in canine acute intervertebral disc disease","author":"Olby NJ","year":"2020","unstructured":"Olby NJ, da Costa RC, Levine JM, Stein VM. Prognostic factors in canine acute intervertebral disc disease. Front. Vet. Sci. 2020;7:596059. doi:10.3389\/fvets.2020.596059"},{"issue":"3","key":"B4","series-title":"J Small Anim Pract","first-page":"136","article-title":"Does surgical timing affect the rapidity of recovery in deep pain-entire non-ambulatory dogs with thoracolumbar intervertebral disc extrusion?","author":"Znoguera LV","year":"2023","unstructured":"Znoguera LV, Pauciulo C, Coriazzoli D, Cauduro A, Motta L. Does surgical timing affect the rapidity of recovery in deep pain-entire non-ambulatory dogs with thoracolumbar intervertebral disc extrusion? J Small Anim Pract. 2023;64(3):136\u2013141. doi:19.1111\/jsap.13570"},{"issue":"4","key":"B5","series-title":"J Am Vet Med Assoc","first-page":"386","article-title":"Factors associated with recovery from paraplegia in dogs with loss of pain perception in the pelvic limbs following intervertebral disk herniation","author":"Jeffery ND","year":"2016","unstructured":"Jeffery ND, Barker AK, Hu HZ, et al. Factors associated with recovery from paraplegia in dogs with loss of pain perception in the pelvic limbs following intervertebral disk herniation. J Am Vet Med Assoc. 2016;248(4):386\u2013394. doi:10.2460\/javma.248.4.386"},{"issue":"5","key":"B6","series-title":"J Vet Intern Med","first-page":"1570","article-title":"ACVIM consensus statement on diagnosis and management of acute canine thoracolumbar intervertebral disc extrusion","author":"Olby NJ","year":"2022","unstructured":"Olby NJ, Moore SA, Brisson B, et al. ACVIM consensus statement on diagnosis and management of acute canine thoracolumbar intervertebral disc extrusion. J Vet Intern Med. 2022;36(5):1570\u20131596. doi:10.1111\/jvim.16480"},{"issue":"4","key":"B7","series-title":"J Am Anim Hosp Assoc","first-page":"188","article-title":"Safety and tolerability of hyperbaric oxygen therapy in cats and dogs","author":"Birnie GL","year":"2018","unstructured":"Birnie GL, Fry DR, Best MP. Safety and tolerability of hyperbaric oxygen therapy in cats and dogs. J Am Anim Hosp Assoc. 2018;54(4):188\u2013194. doi:10.5326\/JAAHA-MS-6548"},{"key":"B8","series-title":"Front Vet Sci","first-page":"764002","article-title":"Common uses and adverse effects of hyperbaric oxygen therapy in a cohort of small animal patients: a retrospective analysis of 2,792 treatment sessions","author":"Montalbano C","year":"2021","unstructured":"Montalbano C, Kiorpes C, Elam L, Miscioscia E, Shmalberg J. Common uses and adverse effects of hyperbaric oxygen therapy in a cohort of small animal patients: a retrospective analysis of 2,792 treatment sessions. Front Vet Sci. 2021;8:764002. doi:10.3389\/fvets.2021.764002"},{"issue":"3","key":"B9","series-title":"J Vet Emerg Crit Care","first-page":"289","article-title":"Hyperbaric oxygen therapy. Part 2: application in disease","author":"Edwards ML","year":"2010","unstructured":"Edwards ML. Hyperbaric oxygen therapy. Part 2: application in disease. J Vet Emerg Crit Care. 2010;20(3):289\u2013297. doi:10.1111\/j.1476-4431.2010.00535"},{"issue":"3","key":"B10","series-title":"J Vet Emerg Crit Care","first-page":"284","article-title":"Hyperbaric oxygen therapy. Part 1: history and principles","author":"Edwards ML","year":"2010","unstructured":"Edwards ML. Hyperbaric oxygen therapy. Part 1: history and principles. 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