{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T15:17:31Z","timestamp":1783005451883,"version":"3.54.5"},"reference-count":50,"publisher":"American Veterinary Medical Association (AVMA)","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"sc_a1\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare dogs with naturally occurring hyperadrenocorticism (Cushing syndrome [CS]) and those receiving prednisolone (PDS; \u2265 0.25 mg\/kg\/d for \u2265 3 consecutive weeks) therapy to assess whether the 2 forms of glucocorticoid excess exhibit distinct coagulation profiles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a2\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross-sectional study included 29 dogs of various breeds, ages, and sexes. The dogs were categorized into 3 groups: a control group (n = 8) and 2 experimental groups (the CS [12] and PDS [9] groups). Reaction time (R), coagulation time (K), \u03b1-angle, maximum amplitude (MA), and clot strength (G) were compared between groups using thromboelastography. The correlations of each parameter with Hct and platelet count were also analyzed in each experimental group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a3\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared with the control, the CS and PDS groups exhibited increased G as indicated by significantly higher MA and G. The PDS and CS groups had shorter K values than the controls. The R was significantly shorter in the PDS group compared with the other groups. In addition, platelet count showed opposing correlations with MA and G in the PDS and CS groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a4\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Dogs in the CS and PDS groups exhibited hypercoagulable profiles on thromboelastography, characterized by enhanced G (higher MA and G). The PDS group uniquely demonstrated faster clot formation kinetics, with significantly shorter R (vs controls and CS) and K (vs controls).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a5\">\n                    <jats:title>Clinical Relevance<\/jats:title>\n                    <jats:p>These findings emphasize the need for functional coagulation monitoring to distinguish specific thrombotic risks associated with the source of glucocorticoid excess.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2460\/ajvr.26.02.0042","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T12:12:16Z","timestamp":1773403936000},"source":"Crossref","is-referenced-by-count":0,"title":["Comparison of coagulation patterns in dogs with Cushing syndrome and prednisolone treatment assessed by thromboelastography"],"prefix":"10.2460","volume":"87","author":[{"given":"Seo-Rim","family":"Koh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong-Ho","family":"Ha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Young","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Ok","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"issue":"6","key":"B1","series-title":"Semin Throm Hemost","first-page":"654","article-title":"Use of glucocorticoids and risk of venous thromboembolism: a narrative review","author":"Simion C","year":"2021","unstructured":"Simion C, Campello E, Bensi E, et al. Use of glucocorticoids and risk of venous thromboembolism: a narrative review. Semin Throm Hemost. 2021;47(6):654\u2013661. doi:10.1055\/s-0040-1722270"},{"issue":"4","key":"B2","series-title":"Vet Clin Pathol","first-page":"426","article-title":"Effect of prednisone administration on coagulation variables in healthy Beagle dogs","author":"Rose LJ","year":"2011","unstructured":"Rose LJ, Dunn ME, Allegret V, B\u00e9dard C. Effect of prednisone administration on coagulation variables in healthy Beagle dogs. Vet Clin Pathol. 2011;40(4):426\u2013434. doi:10.1111\/j.1939-165X.2011.00364.x"},{"issue":"6","key":"B3","series-title":"J Vet Intern Med","first-page":"1292","article-title":"Diagnosis of spontaneous canine hyperadrenocorticism: 2012 ACVIM consensus statement (small animal)","author":"Behrend EN","year":"2013","unstructured":"Behrend EN, Kooistra HS, Nelson R, Reusch CE, Scott-Moncrieff JC. Diagnosis of spontaneous canine hyperadrenocorticism: 2012 ACVIM consensus statement (small animal). J Vet Intern Med. 2013;27(6):1292\u20131304. doi:10.1111\/jvim.12192"},{"issue":"8","key":"B4","series-title":"Animals","first-page":"1299","article-title":"Role of prednisolone in platelet activation by inhibiting TxA2 generation through the regulation of cPLA2 phosphorylation","author":"Kim S","year":"2023","unstructured":"Kim S, Chaudhary PK, Kim S. Role of prednisolone in platelet activation by inhibiting TxA2 generation through the regulation of cPLA2 phosphorylation. Animals. 2023;13(8):1299. doi:10.3390\/ani13081299"},{"issue":"1","key":"B5","series-title":"Rheum Dis Clin North Am","first-page":"15","article-title":"Corticosteroids: mechanisms of action in health and disease","author":"Ramamoorthy S","year":"2016","unstructured":"Ramamoorthy S, Cidlowski JA. Corticosteroids: mechanisms of action in health and disease. 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