{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T16:01:50Z","timestamp":1785513710551,"version":"3.56.0"},"reference-count":37,"publisher":"American Veterinary Medical Association (AVMA)","issue":"8","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2026,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"sc_a1\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess faculty interest in veterinary biospecimens, develop a standardized multi-institutional biological fluid repository across 3 veterinary institutions, and assess quality and fitness for purpose of archived samples.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a2\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a prospective multi-institutional biobanking and feasibility study from 2022 through 2025. Faculty from each institution were administered a voluntary and anonymous survey via email, and responses were recorded. Biological fluid specimens were collected and archived from the Neurology and Neurosurgery Services of each participating institution. A shared database (Freezerworks) was utilized by all 3 institutions to annotate each sample with clinical data and record the storage location. Selected serum (n = 12), CSF (n = 12), and urine (n = 9) samples were assessed for quality control and fitness for purpose by measuring concentrations of putative biomarkers via ELISAs and single-molecule array, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a3\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Faculty surveys indicated widespread support for centralized institutional biobanking, with 94 of 170 respondents (55%) in favor of a combination of institutional and investigator financial support. Over 2,500 biological specimens from dogs and cats with neurological disease were collected during the 3-year study period. Sample quality across serum, urine, and CSF was consistent across institutions. Moreover, serum samples from randomly selected dogs with divergent diagnoses yielded robust and discriminatory concentrations of putative neurodegenerative disease proteins.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a4\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Multi-institutional veterinary biobanking is feasible and productive, providing investigators with access to clinically annotated, high-quality biospecimens.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a5\">\n                    <jats:title>Clinical Relevance<\/jats:title>\n                    <jats:p>A common repository registry, wherein investigators have reciprocal access to standardized biospecimens, will connect investigators from all domains to promote rigorous, well-powered multicenter studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2460\/ajvr.26.02.0045","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T14:16:47Z","timestamp":1778509007000},"source":"Crossref","is-referenced-by-count":0,"title":["Establishing a standardized biorepository across 3 clinical and translational science center\u2013affiliated veterinary institutions is feasible and productive"],"prefix":"10.2460","volume":"87","author":[{"given":"LaTasha K.","family":"Crawford","sequence":"first","affiliation":[{"name":"Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI"},{"name":"NeuroBiobank, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI"},{"name":"Contributed equally to this work."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molly E.","family":"Church","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA"},{"name":"Contributed equally to this work."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. A.","family":"Boudreaux","sequence":"additional","affiliation":[{"name":"Office of Professional Education, School of Veterinary Medicine, University of California-Davis, Davis, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. N.","family":"Lapin","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauryn A.","family":"Hahn","sequence":"additional","affiliation":[{"name":"Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie J.","family":"Solis","sequence":"additional","affiliation":[{"name":"Clinical and Translational Science Center, University of California-Davis, Davis, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachael","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Zetterberg","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI"},{"name":"Wisconsin Alzheimer\u2019s Disease Research Center, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI"},{"name":"Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, M\u00f6lndal, Sweden"},{"name":"Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, M\u00f6lndal, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda","family":"Catacci Guimaraes","sequence":"additional","affiliation":[{"name":"Veterinary Neurology Biobank, School of Veterinary Medicine, University of California-Davis, Davis, CA"},{"name":"Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam","family":"Shen","sequence":"additional","affiliation":[{"name":"Veterinary Neurology Biobank, School of Veterinary Medicine, University of California-Davis, Davis, CA"},{"name":"Department of Molecular Biosciences, School of Veterinary Medicine, University of California-Davis, Davis, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan G.","family":"Toedebusch","sequence":"additional","affiliation":[{"name":"Veterinary Neurology Biobank, School of Veterinary Medicine, University of California-Davis, Davis, CA"},{"name":"Department of Molecular Biosciences, School of Veterinary Medicine, University of California-Davis, Davis, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8062-0028","authenticated-orcid":true,"given":"Karen","family":"Vernau","sequence":"additional","affiliation":[{"name":"Veterinary Neurology Biobank, School of Veterinary Medicine, University of California-Davis, Davis, CA"},{"name":"Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrien","family":"Dupanloup","sequence":"additional","affiliation":[{"name":"Veterinary Neurology Biobank, School of Veterinary Medicine, University of California-Davis, Davis, CA"},{"name":"Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"Panek","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences & Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Starr","family":"Cameron","sequence":"additional","affiliation":[{"name":"NeuroBiobank, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI"},{"name":"Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3216-3344","authenticated-orcid":true,"given":"Christine M.","family":"Toedebusch","sequence":"additional","affiliation":[{"name":"Veterinary Neurology Biobank, School of Veterinary Medicine, University of California-Davis, Davis, CA"},{"name":"Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA"},{"name":"Department of Molecular Biosciences, School of Veterinary Medicine, 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