{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T12:01:23Z","timestamp":1791633683850,"version":"4.3.4"},"reference-count":27,"publisher":"American Veterinary Medical Association (AVMA)","issue":"8","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2026,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"sc_a1\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To evaluate the effect of a commercially available heated anesthetic circuit (HAC; Heated ZDS Qube; Darvall) on body temperature in anesthetized New Zealand white rabbits (\n                      <jats:italic>Oryctolagus cuniculus<\/jats:italic>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a2\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Rabbits were anesthetized in a research facility over approximately 2 weeks in a randomized, complete crossover design (June 4 to 13, 2024). Each animal was sedated, then anesthetized with isoflurane twice (7-day washout) with a warmed (W) or nonwarmed (NW) HAC. Once intubated, the HAC was connected and preheated (43.3\u2009\u00b0C) for W or off (room temperature) for NW events. Temperature (rectal and 2 esophageal modalities) was recorded every 5 minutes under anesthesia. At 60 minutes, anesthesia was discontinued. Once responsive, the animal was moved to an incubator (29.4\u2009\u00b0C). Rectal temperature was recorded every 30 minutes until normothermic (\u2265 38\u2009\u00b0C). Statistical analysis included descriptive statistics, paired\n                      <jats:italic>t<\/jats:italic>\n                      tests, and a linear mixed-effects model, with significance at\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a3\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>10 healthy approximately 4-month-old intact male rabbits were included. Hypothermia (\u2264 37.9\u2009\u00b0C) occurred in 10 of 10 NW and 7 of 10 W events. Temperature decreased linearly with anesthesia time in all events. Mean W temperatures were significantly higher than NW at all time points; rectal (regression coefficient, \u22120.19; 95% CI, \u22120.26, \u22120.12), Darvall esophageal (\u20130.40; 95% CI, \u22120.49, \u22120.31), and Vmed esophageal temperature (\u22120.31; 95% CI, \u22120.38, \u22120.23).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a4\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This HAC may be useful for minimizing perianesthetic hypothermia in rabbits.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a5\">\n                    <jats:title>Clinical Relevance<\/jats:title>\n                    <jats:p>Hypothermia is a common anesthetic complication in rabbits. Determining effective methods to minimize perianesthetic heat loss is critical.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2460\/ajvr.26.02.0062","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:43:45Z","timestamp":1777387425000},"source":"Crossref","is-referenced-by-count":1,"title":["Use of a heated anesthetic circuit decreases heat loss compared to a nonwarmed circuit in anesthetized New Zealand white rabbits (Oryctolagus cuniculus)"],"prefix":"10.2460","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3207-8297","authenticated-orcid":true,"given":"Greta","family":"Doden","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daneeya","family":"Guthrie","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pratyaydipta","family":"Rudra","sequence":"additional","affiliation":[{"name":"Department of Statistics, College of Arts and Sciences, Oklahoma State University, Stillwater, OK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5414-0816","authenticated-orcid":true,"given":"Julianne E.","family":"McCready","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5673-7218","authenticated-orcid":true,"given":"Jo\u00e3o","family":"Brand\u00e3o","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"issue":"3","key":"B1","series-title":"J Am Vet Med Assoc","first-page":"288","article-title":"Prognostic value of rectal temperature at hospital admission in client-owned rabbits","author":"Di Girolamo N","year":"2016","unstructured":"Di Girolamo N, Toth G, Selleri P. 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Crit Care Med. 2015;43(10):2228\u20132238. doi:10.1097\/CCM.0000000000001223"},{"issue":"4","key":"B6","series-title":"Aust Vet J","first-page":"158","article-title":"Effect of hypothermia on recovery from general anaesthesia in the dog","author":"Pottie RG","year":"2007","unstructured":"Pottie RG, Dart CM, Perkins NR, Hodgson DR. Effect of hypothermia on recovery from general anaesthesia in the dog. Aust Vet J. 2007;85(4):158\u2013162. doi:10.1111\/j.1751-0813.2007.00128.x"},{"issue":"6","key":"B7","series-title":"Anesthesiology","first-page":"1318","article-title":"Mild intraoperative hypothermia prolongs postanesthetic recovery","author":"Lenhardt R","year":"1997","unstructured":"Lenhardt R, Marker E, Goll V, et al. Mild intraoperative hypothermia prolongs postanesthetic recovery. Anesthesiology. 1997;87(6):1318\u20131323. doi:10.1097\/00000542-199712000-00009"},{"issue":"5","key":"B8","series-title":"Vet Anaesth Analg","first-page":"365","article-title":"The risk of death: the confidential enquiry into perioperative small animal fatalities","author":"Brodbelt DC","year":"2008","unstructured":"Brodbelt DC, Blissitt KJ, Hammond RA, et al. The risk of death: the confidential enquiry into perioperative small animal fatalities. Vet Anaesth Analg. 2008;35(5):365\u2013373. doi:10.1111\/j.1467-2995.2008.00397.x"},{"issue":"4","key":"B9","series-title":"Vet Anaesth Analg","first-page":"520","article-title":"Peri-anaesthetic mortality and nonfatal gastrointestinal complications in pet rabbits: a retrospective study on 210 cases","author":"Lee HW","year":"2018","unstructured":"Lee HW, Machin H, Adami C. Peri-anaesthetic mortality and nonfatal gastrointestinal complications in pet rabbits: a retrospective study on 210 cases. 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Comparison of heating devices for maintaining body temperature in anesthetized laboratory rabbits (Oryctolagus cuniculus). J Am Assoc Lab Anim Sci. 2007;46(3):61\u201363."},{"issue":"3","key":"B12","series-title":"Vet Anaesth Analg","first-page":"280","article-title":"Comparison of three different methods to prevent heat loss in healthy dogs undergoing 90 minutes of general anesthesia","author":"Clark-Price SC","year":"2013","unstructured":"Clark-Price SC, Dossin O, Jones KR, Otto AN, Weng HY. Comparison of three different methods to prevent heat loss in healthy dogs undergoing 90 minutes of general anesthesia. 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Evaluation of four warming procedures to minimise heat loss induced by anaesthesia and surgery in dogs. Aust Vet J. 2004;82(1\u20132):65\u201368. doi:10.1111\/j.1751-0813.2004.tb14646.x"},{"key":"B20","author":"Schoenfeld D","year":"2023","unstructured":"Schoenfeld D. Statistical considerations for a cross-over study where the outcome is a measurement. Harvard University. Accessed October 19, 2023. http:\/\/hedwig.mgh.harvard.edu\/sample_size\/js\/js_crossover_quant.html"},{"issue":"4","key":"B21","series-title":"Am J Vet Res","first-page":"ajvr.25.09.0317","article-title":"Isoflurane anesthesia and body temperature changes do not significantly affect Viscoelastic Coagulation Monitor Vet viscoelastography of New Zealand white rabbits (Oryctolagus cuniculus)","author":"Doden G","year":"2025","unstructured":"Doden G, Guthrie D, Rudra P, McCready JE, Brand\u00e3o J. Isoflurane anesthesia and body temperature changes do not significantly affect Viscoelastic Coagulation Monitor Vet viscoelastography of New Zealand white rabbits (Oryctolagus cuniculus). Am J Vet Res. 2025;87(4):ajvr.25.09.0317. doi:10.2460\/ajvr.25.09.0317"},{"key":"B22","author":"Urbaniak G","unstructured":"Urbaniak G, Plous S. Research randomizer. Version 4.0. Accessed June 3, 2024. http:\/\/www.randomizer.org\/"},{"key":"B23","series-title":"Ferrets, Rabbits, and Rodents: Clinical Medicine and Surgery","first-page":"150","article-title":"Basic approach to veterinary care of rabbits","author":"Brand\u00e3o J","year":"2021","unstructured":"Brand\u00e3o J, Graham J, Quesenberry KE. Basic approach to veterinary care of rabbits. In: Quesenberry KE, Orcutt CJ, Mans C, Carpenter JW, eds. Ferrets, Rabbits, and Rodents: Clinical Medicine and Surgery. 4th ed. Elsevier; 2021:150\u2013161."},{"issue":"26","key":"B24","series-title":"Vet Rec","first-page":"658","article-title":"Reference intervals for coagulation times using two point-of-care analysers in healthy pet rabbits (Oryctolagus cuniculus)","author":"Mentr\u00e9 V","year":"2014","unstructured":"Mentr\u00e9 V, Bulliot C, Linsart A, Ronot P. Reference intervals for coagulation times using two point-of-care analysers in healthy pet rabbits (Oryctolagus cuniculus). Vet Rec. 2014;174(26):658. doi:10.1136\/vr.102289"},{"issue":"5","key":"B25","series-title":"Anesth Analg","first-page":"1007","article-title":"Mild hypothermia alters propofol pharmacokinetics and increases the duration of action of atracurium","author":"Leslie K","year":"1995","unstructured":"Leslie K, Sessler DI, Bjorksten AR, Moayeri A. Mild hypothermia alters propofol pharmacokinetics and increases the duration of action of atracurium. Anesth Analg. 1995;80(5):1007\u20131021. doi:10.1097\/00000539-199505000-00027"},{"issue":"1","key":"B26","series-title":"J Vet Emerg Crit Care","first-page":"32","article-title":"Perioperative hypothermia","author":"Armstrong SR","year":"2005","unstructured":"Armstrong SR, Roberts BK, Aronsohn M. Perioperative hypothermia. J Vet Emerg Crit Care. 2005;15(1):32\u201337. doi:10.1111\/j.1476-4431.2005.04033.x"},{"issue":"7","key":"B27","series-title":"Paediatr Anaesth","first-page":"574","article-title":"Risk factors influencing inadvertent hypothermia in infants and neonates during anesthesia","author":"Tander B","year":"2005","unstructured":"Tander B, Baris S, Karakaya D, Ariturk E, Rizalar R, Bernay F. Risk factors influencing inadvertent hypothermia in infants and neonates during anesthesia. 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