{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T16:03:36Z","timestamp":1785513816319,"version":"3.56.0"},"reference-count":25,"publisher":"American Veterinary Medical Association (AVMA)","issue":"8","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2026,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"sc_a1\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate preoperative parathyroid hormone (PTH) concentration as a predictor of moderate to severe postoperative hypocalcemia following parathyroidectomy in dogs with primary hyperparathyroidism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a2\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective analysis of dogs undergoing parathyroidectomy for primary hyperparathyroidism and excluding dogs receiving prophylactic calcitriol. Preoperative serum PTH measurement was stratified into groups by multiples of the assay-specific upper limit of normal (ULN). Whole blood ionized calcium (iCa) nadir was used to classify postoperative outcome, with moderate to severe hypocalcemia defined as iCa &lt; 1.00 mmol\/L.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a3\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>92 dogs were included. Moderate to severe hypocalcemia occurred in 36 dogs (39.1%). A graded relationship was identified between PTH strata and moderate to severe hypocalcemia: 9 of 47 dogs (19.1%) with normal PTH, 14 of 27 (51.9%) with &gt; 1 to 2 times ULN, 5 of 10 (50.0%) with &gt; 2 to 3 times ULN, and 8 of 8 (100%) with &gt; 3 times ULN. A PTH cutoff of 1.05 times ULN yielded an area under the curve of 0.76 (95% CI, 0.65 to 0.86), with 72.2% sensitivity and 71.4% specificity. Median time to overall calcium nadir was 65.8 hours (range, 3.7 to 19,794.1), with 40 of 92 dogs (43.5%) reaching nadir after 72 hours. Late nadirs were common in dogs with moderate to severe hypocalcemia (25 of 36 [69.4%]) versus normocalcemia (10 of 44 [22.7%]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a4\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Preoperative PTH concentration stratified by ULN multiples demonstrates a graded relationship with postoperative hypocalcemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a5\">\n                    <jats:title>Clinical Relevance<\/jats:title>\n                    <jats:p>PTH-based stratification could identify high-risk patients warranting prophylactic therapeutics and extended monitoring.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2460\/ajvr.26.03.0086","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T19:56:23Z","timestamp":1779998183000},"source":"Crossref","is-referenced-by-count":0,"title":["Preoperative parathyroid hormone concentration predicts postoperative hypocalcemia severity in dogs undergoing parathyroidectomy"],"prefix":"10.2460","volume":"87","author":[{"given":"Elizabeth","family":"Daugherty","sequence":"first","affiliation":[{"name":"Veterinary Specialty Services, Manchester, MO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chevonne","family":"Codd","sequence":"additional","affiliation":[{"name":"Veterinary Specialty Services, Manchester, MO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Howard","sequence":"additional","affiliation":[{"name":"Veterinary Specialty Services, Manchester, MO"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"issue":"5","key":"B1","series-title":"J Am Vet Med Assoc","first-page":"756","article-title":"Pretreatment clinical and laboratory findings in dogs with primary hyperparathyroidism: 210 cases (1987\u20132004)","volume":"227","author":"Feldman EC","year":"2005","unstructured":"Feldman EC, Hoar B, Pollard R, Nelson RW. Pretreatment clinical and laboratory findings in dogs with primary hyperparathyroidism: 210 cases (1987\u20132004). J Am Vet Med Assoc. 2005;227(5):756\u2013761. doi:10.2460\/javma.2005.227.756"},{"issue":"11","key":"B2","series-title":"J Am Vet Med Assoc","first-page":"1309","article-title":"Incidence, survival time, and surgical treatment of parathyroid carcinomas in dogs: 100 cases (2010\u20132019)","volume":"259","author":"Erickson AK","year":"2021","unstructured":"Erickson AK, Regier PJ, Watt MM, et al. Incidence, survival time, and surgical treatment of parathyroid carcinomas in dogs: 100 cases (2010\u20132019). 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