{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:05:04Z","timestamp":1790874304914,"version":"4.1.0"},"reference-count":23,"publisher":"American Veterinary Medical Association (AVMA)","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"sc_a1\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To evaluate the efficacy of a modified-live\n                      <jats:italic>Mycoplasmopsis bovis<\/jats:italic>\n                      vaccine administered to 1-week-old calves against virulent\n                      <jats:italic>M bovis<\/jats:italic>\n                      challenge and the immunological response of calves after revaccination.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a2\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      2 studies were conducted using seronegative calves. In study 1, 85 calves received 2 SC doses of either vaccine or placebo 21 days apart and were challenged with virulent\n                      <jats:italic>M bovis<\/jats:italic>\n                      on days 32 to 34. Clinical signs, fever, and lung lesions were monitored. In study 2, 20 calves were assigned to control or vaccine groups. Calves received SC doses on days 0 and 21 and a revaccination on day 119 with their respective treatments. Serological responses were assessed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a3\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In study 1, vaccinated calves showed significantly (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .05) reduced lung lesions (5% vs 19% of total lung with lesions), shorter duration of clinical signs (1.3 vs 5.7 days), and fewer febrile days (2.9 vs 9.3) than controls. Antibody titers were higher at challenge and after challenge in vaccinates. Study 2 confirmed a similar response profile after 2 doses of\n                      <jats:italic>M bovis<\/jats:italic>\n                      vaccine and robust serological response after revaccination on day 119.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a4\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The modified-live\n                      <jats:italic>M bovis<\/jats:italic>\n                      vaccine induced immunity against virulent\n                      <jats:italic>M bovis<\/jats:italic>\n                      challenge, with a reduction of lung lesions and clinical signs. A 2-dose regimen with a day 119 revaccination elicited a strong anamnestic response.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a5\">\n                    <jats:title>Clinical Relevance<\/jats:title>\n                    <jats:p>\n                      This vaccine can be introduced into bovine respiratory disease management in the natural setting to assess its impact on production by reducing the impact of\n                      <jats:italic>M bovis<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.2460\/ajvr.26.03.0090","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T17:35:19Z","timestamp":1783532119000},"source":"Crossref","is-referenced-by-count":0,"title":["Vaccination of neonatal calves with a modified-live Mycoplasma (Mycoplasmopsis) bovis vaccine confers protection and enhances immunity"],"prefix":"10.2460","volume":"87","author":[{"given":"Leentje","family":"Dreesen","sequence":"first","affiliation":[{"name":"Research and Development, Zoetis Inc, Zaventem, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Asper","sequence":"additional","affiliation":[{"name":"Research and Development, Zoetis Inc, Kalamazoo, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Sobecki","sequence":"additional","affiliation":[{"name":"Research and Development, Zoetis Inc, Kalamazoo, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suman M.","family":"Mahan","sequence":"additional","affiliation":[{"name":"Research and Development, Zoetis Inc, Kalamazoo, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd","family":"Meinert","sequence":"additional","affiliation":[{"name":"Research and Development, Zoetis Inc, Kalamazoo, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kay","family":"Genteman","sequence":"additional","affiliation":[{"name":"Research and Development, Zoetis Inc, Kalamazoo, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Ketteler","sequence":"additional","affiliation":[{"name":"Research and Development, Zoetis Inc, Kalamazoo, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Martinon","sequence":"additional","affiliation":[{"name":"Research and Development, Zoetis Inc, Kalamazoo, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ely","family":"B\u00e9n\u00e9r\u00e9","sequence":"additional","affiliation":[{"name":"Research and Development, Zoetis Inc, Zaventem, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Peterson","sequence":"additional","affiliation":[{"name":"Research and Development, Zoetis Inc, Kalamazoo, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krystina","family":"Anderson","sequence":"additional","affiliation":[{"name":"Research and Development, Zoetis Inc, Kalamazoo, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Brueck","sequence":"additional","affiliation":[{"name":"Research and Development, Zoetis Inc, Kalamazoo, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liya","family":"Anto","sequence":"additional","affiliation":[{"name":"Research and Development, Zoetis Inc, Kalamazoo, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhijit","family":"Gurjar","sequence":"additional","affiliation":[{"name":"Research and Development, Zoetis Inc, Kalamazoo, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Moulin","sequence":"additional","affiliation":[{"name":"Research and Development, Zoetis Inc, Kalamazoo, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"issue":"17","key":"B1","series-title":"Vet Rec","first-page":"459","article-title":"Bovine mycoplasmosis: silent and deadly","volume":"168","author":"Nicholas RAJ","year":"2011","unstructured":"Nicholas RAJ. 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