{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T13:15:02Z","timestamp":1788268502917,"version":"build-2803163510"},"reference-count":31,"publisher":"American Veterinary Medical Association (AVMA)","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"sc_a1\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine whether urinary electrolyte indices measured after IV furosemide administration are associated with clinical outcomes in dogs with left-sided acute congestive heart failure (CHF) secondary to myxomatous mitral valve disease (MMVD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a2\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this multicenter retrospective study, client-owned dogs with acute left-sided CHF caused by MMVD presenting to 3 referral hospitals between January 2024 and December 2025 were evaluated. All dogs received a single IV bolus of furosemide (2 mg\/kg) at presentation. Urine samples were collected from the first spontaneous urination within 2 hours after furosemide administration. Urinary sodium concentration, urinary sodium-to-potassium ratio (uNa:K), and urinary sodium-to-chloride ratio were measured. Associations between urinary electrolyte indices and clinical variables were analyzed. Clinical outcomes included change in radiographic pulmonary congestion score, hospitalization duration, and survival to discharge.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a3\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>50 dogs met the inclusion criteria. Higher urinary sodium concentration and uNa:K were associated with greater improvement in radiographic pulmonary congestion and shorter hospitalization. Dogs that survived to discharge had a higher uNa:K than those that died during hospitalization. Urinary electrolyte indices were not significantly correlated with echocardiographic or radiographic indices of left atrial size.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a4\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Urinary electrolyte indices measured after IV furosemide administration were associated with clinically relevant outcomes in dogs hospitalized with acute left-sided CHF secondary to MMVD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a5\">\n                    <jats:title>Clinical Relevance<\/jats:title>\n                    <jats:p>Spot urinary electrolyte measurements may provide a simple and noninvasive tool for assessing diuretic response and clinical status in dogs with acute left-sided CHF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2460\/ajvr.26.03.0109","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T12:47:57Z","timestamp":1782910077000},"source":"Crossref","is-referenced-by-count":0,"title":["Spot urinary electrolytes are associated with decongestion and duration of hospitalization in dogs with acute left-sided congestive heart failure secondary to myxomatous mitral valve disease"],"prefix":"10.2460","volume":"87","author":[{"given":"Jaechun","family":"Cho","sequence":"first","affiliation":[{"name":"Department of Veterinary Internal Medicine, College of Veterinary Medicine, Jeonbuk National University, Iksan, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minsuk","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Veterinary Internal Medicine, College of Veterinary Medicine, Jeonbuk National University, Iksan, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihyun","family":"Choi","sequence":"additional","affiliation":[{"name":"Bon Animal Medical Center, Suwon, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeongmin","family":"Lee","sequence":"additional","affiliation":[{"name":"Cheongju Korea Animal Medical Center, Cheongju, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chul","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Veterinary Internal Medicine, College of Veterinary Medicine, Jeonbuk National University, Iksan, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"issue":"3","key":"B1","series-title":"J Vet Intern Med","first-page":"1127","article-title":"ACVIM consensus guidelines for the diagnosis and treatment of myxomatous mitral valve disease in dogs","volume":"33","author":"Keene BW","year":"2019","unstructured":"Keene BW, Atkins CE, Bonagura JD, et al. 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