{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T21:59:44Z","timestamp":1789682384954,"version":"4.0.1"},"reference-count":65,"publisher":"American Veterinary Medical Association (AVMA)","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n To evaluate pretreatment biomarkers for predicting the severity of corticosteroid-induced hyperinsulinemia.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Oral glucose tests were performed before (day 1) and after (day 8) a dexamethasone course (0.08 mg\/kg, q 48 h) in 24 healthy adult Standardbreds. Associations between day 8 oral glucose test insulin parameters (baseline [T0\n insulin<\/jats:sub>\n ], maximal [Cmax\n insulin<\/jats:sub>\n ], and area under the curve [AUC\n insulin<\/jats:sub>\n ]) and day 1 serum markers (insulin, glucose, adiponectin, leptin, and their ratios) were examined using Spearman correlation, log-linked generalized linear models. Relative risk of exceeding specific insulin thresholds was evaluated for horses with pretreatment markers above and below reference ranges.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Day 8 insulin increased by (mean) 11.5-fold (range, 2 to 37; T0\n insulin<\/jats:sub>\n ), 6.5-fold (range, 2 to 17; Cmax\n insulin<\/jats:sub>\n ), and 6.6-fold (range, 2 to 15; AUC\n insulin<\/jats:sub>\n ) over day 1 values (\n P<\/jats:italic>\n < .001). Day 1 adiponectin had the strongest correlation with day 8 Cmax\n insulin<\/jats:sub>\n (\u03c1 = \u22120.67;\n P<\/jats:italic>\n < .001) and AUC\n insulin<\/jats:sub>\n (\u03c1 = \u22120.68;\n P<\/jats:italic>\n < .001). Day 1 leptin-to-adiponectin ratio had the strongest correlation with day 8 resting insulin (\u03c1 = 0.68;\n P<\/jats:italic>\n < .001) and was also the best predictor of day 8 T0\n insulin<\/jats:sub>\n , Cmax\n insulin<\/jats:sub>\n , and AUC\n insulin<\/jats:sub>\n on generalized linear model analysis (\n P<\/jats:italic>\n < .0001). Horses with a leptin-to-adiponectin ratio > 1 were 4.9 times (range, 1.5 to 18.2) more likely to have day 8 T0\n insulin<\/jats:sub>\n > 100 \u00b5IU\/mL (\n P<\/jats:italic>\n = .01).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Pretreatment leptin, adiponectin, and leptin-to-adiponectin ratio are predictors of corticosteroid-associated hyperinsulinemia.<\/jats:p>\n <\/jats:sec>\n \n Clinical Relevance<\/jats:title>\n Adipokines warrant clinical evaluation as biomarkers of risk for corticosteroid-associated hyperinsulinemia and laminitis.<\/jats:p>\n <\/jats:sec>","DOI":"10.2460\/ajvr.26.03.0123","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T18:57:30Z","timestamp":1781204250000},"source":"Crossref","is-referenced-by-count":1,"title":["Serum adipokines are useful for predicting hyperinsulinemia secondary to corticosteroid treatment in horses"],"prefix":"10.2460","volume":"87","author":[{"given":"Andrew W.","family":"van Eps","sequence":"first","affiliation":[{"name":"Department of Clinical Studies, School of Veterinary Medicine, New Bolton Center, University of Pennsylvania, Kennett Square, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2820-8431","authenticated-orcid":true,"given":"Fran\u00e7ois-Ren\u00e9","family":"Bertin","sequence":"additional","affiliation":[{"name":"Nancy Fair Link Laminitis Research Center, Mississippi State University, Starkville, MS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darko","family":"Stefanovski","sequence":"additional","affiliation":[{"name":"Department of Clinical Studies, School of Veterinary Medicine, New Bolton Center, University of Pennsylvania, Kennett Square, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"issue":"3","key":"B1","series-title":"Vet Rec","first-page":"79","article-title":"Steroids and laminitis \u2013 the value of evidence over anecdote","volume":"185","author":"Rendle D","year":"2019","unstructured":"Rendle D. 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