{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:53:23Z","timestamp":1791226403919,"version":"4.1.0"},"reference-count":85,"publisher":"American Veterinary Medical Association (AVMA)","license":[{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2026,10,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"sc_a1\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To characterize effects of inflammatory cytokine priming on viability, mitochondrial morphology, and extracellular vesicle (EV) cargo in feline placenta-derived mesenchymal stromal cells (MSCs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a2\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Feline placenta-derived MSCs from 7 healthy cats were cultured under control, serum-deprived, or cytokine-stimulated (tumor necrosis factor\u2013\u03b1, interferon-\u03b3, IL-1, IL-6) conditions in vitro. Viability\/apoptosis were assessed by flow cytometry and mitochondrial morphology by confocal microscopy with MicroP\/MATLAB; EVs were characterized by surface markers, RNA sequencing, and microRNA (miR) profiling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a3\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Viability exceeded 96% across all conditions, with no significant intergroup differences. Kiel 67 proliferation marker  and metabolic activity were significantly reduced under serum\u2013free and cytokine-stimulated conditions versus controls (both\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .001). Cytokine priming increased branching and simple tubular mitochondria, whereas serum deprivation increased fragmented forms. Extracellular vesicle transcriptomics identified 329 differentially expressed genes, including upregulated immunosuppressive receptors C-C motif chemokine receptor 8 and poliovirus receptor\u2013related immunoglobulin domain\u2013containing protein and downregulated proinflammatory histone transcripts. microRNA (miR) profiling revealed 23 differentially expressed miRs, with enrichment of anti-inflammatory miR-204, let-7g, and miR-181b-2 and depletion of proinflammatory miR-34a and miR-320a.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a4\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Cytokine priming induces mitochondrial elongation and shifts EV cargo toward an immunosuppressive phenotype without compromising viability, supporting inflammatory priming as a strategy to optimize MSC-based therapies for T-cell\u2013mediated inflammatory diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a5\">\n                    <jats:title>Clinical Relevance<\/jats:title>\n                    <jats:p>Inflammatory priming prior to MSC administration may enhance therapeutic efficacy in cats, supporting investigation of cytokine licensing as a translatable approach to improving MSC therapy outcomes in veterinary medicine.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2460\/ajvr.26.05.0197","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:07:38Z","timestamp":1791223658000},"page":"1-13","source":"Crossref","is-referenced-by-count":0,"title":["Cytokine priming shifts mitochondrial architecture and extracellular vesicle cargo of feline placental mesenchymal stromal cells toward an immunosuppressive phenotype"],"prefix":"10.2460","author":[{"given":"Maria","family":"Soltero-Rivera","sequence":"first","affiliation":[{"name":"Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA"},{"name":"School of Veterinary Medicine, Veterinary Institute for Regenerative Cures, University of California-Davis, Davis, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boaz","family":"Arzi","sequence":"additional","affiliation":[{"name":"Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA"},{"name":"School of Veterinary Medicine, Veterinary Institute for Regenerative Cures, University of California-Davis, Davis, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof","family":"Marycz","sequence":"additional","affiliation":[{"name":"Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA"},{"name":"International Institute of Translational Medicine, Malin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"issue":"1","key":"B1","series-title":"Stem Cell Res Ther","first-page":"115","article-title":"A multicenter experience using adipose-derived mesenchymal stem cell therapy for cats with chronic, non-responsive gingivostomatitis","volume":"11","author":"Arzi B","year":"2020","unstructured":"Arzi B, Peralta S, Fiani N, et al. 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