{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T14:59:02Z","timestamp":1786460342138,"version":"build-2736575974"},"reference-count":28,"publisher":"American Veterinary Medical Association (AVMA)","license":[{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2026,8,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"sc_a1\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare CT-derived liver volume and noncontrast attenuation variables between dogs with histopathologic findings compatible with primary hypoplasia of the portal vein (PHPV) and dogs without liver disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a2\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Medical records were retrospectively reviewed for dogs with abdominal CT and liver histopathology compatible with PHPV. Controls were 121 dogs without liver disease from a published CT reference cohort and were not matched by breed, age, sex, or body weight. Liver volume was evaluated with allometric regression of log-transformed liver volume on log-transformed body weight and group. A body weight\u2013restricted sensitivity analysis was performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a3\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      26 dogs with PHPV-compatible histopathology and 121 controls were analyzed. Affected dogs were substantially lighter than controls (median body weight, 2.13 vs 38.0 kg). In the primary allometric model, the adjusted geometric mean ratio for liver volume in affected dogs versus controls was 0.887 (95% CI, 0.751 to 1.047;\n                      <jats:italic>P<\/jats:italic>\n                      = .156). The body weight\u2013restricted sensitivity analysis was similar (0.923; 95% CI, 0.769 to 1.107;\n                      <jats:italic>P<\/jats:italic>\n                      = .377). Noncontrast hepatic attenuation did not differ significantly between groups, and qualitative CT abnormalities were uncommon.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a4\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>After allometric adjustment, CT-derived liver volume was not detectably lower in dogs with PHPV-compatible histopathology. This finding should be interpreted cautiously because groups differed substantially in body weight and closely body weight\u2013matched controls were unavailable.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a5\">\n                    <jats:title>Clinical Relevance<\/jats:title>\n                    <jats:p>These findings do not support using absence of CT-detectable microhepatia to exclude PHPV. Computed tomography volumetry should be interpreted with body size, vascular imaging, clinical findings, and histopathology, especially when controls are not closely matched by body weight.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2460\/ajvr.26.05.0211","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T12:45:31Z","timestamp":1786452331000},"page":"1-10","source":"Crossref","is-referenced-by-count":0,"title":["Computed tomography\u2013derived liver volume is not detectably lower in dogs with histopathologic findings compatible with primary hypoplasia of the portal vein"],"prefix":"10.2460","author":[{"given":"Yasufumi","family":"Teramura","sequence":"first","affiliation":[{"name":"Ve. C. Jiyugaoka Animal Medical Center, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Tae","family":"Park","sequence":"additional","affiliation":[{"name":"Ve. C. Jiyugaoka Animal Medical Center, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7816-8311","authenticated-orcid":true,"given":"Masahiro","family":"Murakami","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"issue":"1","key":"B1","series-title":"Vet Sci","first-page":"10","article-title":"Anomalies of the portal venous system in dogs and cats as seen on multidetector-row computed tomography: an overview and systematization proposal","volume":"6","author":"Bertolini G","year":"2019","unstructured":"Bertolini G. Anomalies of the portal venous system in dogs and cats as seen on multidetector-row computed tomography: an overview and systematization proposal. 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