{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T16:10:14Z","timestamp":1788883814710,"version":"build-2803163510"},"reference-count":26,"publisher":"American Veterinary Medical Association (AVMA)","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2026,9,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"sc_a1\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To characterize CT perfusion (CTP) in canine massive hepatocellular carcinoma (HCC) and explore associations with descriptive histomorphologic differentiation categories.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a2\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study included 20 client-owned dogs with surgically excised, histopathologically confirmed HCC of the massive gross phenotype and interpretable preoperative CTP datasets. Hepatic arterial flow (HAF), portal venous flow (PVF), and hepatic perfusion index (HPI) were calculated with a dual-input maximum-slope method. Freehand tumor regions of interest were drawn as large as possible along tumor margins while excluding visible vessels and necrotic or cystic regions. The CTP metrics were compared between tumor and nontumorous liver and among differentiation groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a3\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Tumors had lower PVF than nontumorous liver (23.40 vs 127.15 mL\/min\/100 mL;\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .001) and higher HPI (65.81% vs 29.66%;\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .001), whereas HAF did not differ (52.98 vs 50.29 mL\/min\/100 mL;\n                      <jats:italic>P<\/jats:italic>\n                      = .154). Among differentiation groups, HAF differed (global\n                      <jats:italic>P<\/jats:italic>\n                      = .011; well &gt; moderate; adjusted\n                      <jats:italic>P<\/jats:italic>\n                      = .042), PVF differed (global\n                      <jats:italic>P<\/jats:italic>\n                      = .025; poor &lt; well; adjusted\n                      <jats:italic>P<\/jats:italic>\n                      = .031), and HPI did not differ (global\n                      <jats:italic>P<\/jats:italic>\n                      = .664).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a4\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Canine HCC showed relative arterial dominance on CTP driven mainly by reduced PVF. Although HAF and PVF differed among differentiation categories, these findings should be interpreted cautiously because only 3 tumors were poorly differentiated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a5\">\n                    <jats:title>Clinical Relevance<\/jats:title>\n                    <jats:p>CTP may provide quantitative arterial and portal perfusion information but should not replace morphologic imaging, surgical assessment, or other established diagnostic and prognostic approaches; it cannot define histologic type or differentiation or predict metastasis, resectability, or prognosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2460\/ajvr.26.05.0219","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T15:48:11Z","timestamp":1788882491000},"page":"1-9","source":"Crossref","is-referenced-by-count":0,"title":["Computed tomography perfusion indicates reduced portal venous perfusion and relative arterial dominance in canine hepatocellular carcinoma"],"prefix":"10.2460","author":[{"given":"Pinhui","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Fujisawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumiko","family":"Ishigaki","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Fujisawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chieko","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Fujisawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoko","family":"Shiozawa","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Fujisawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miran","family":"Kimpara","sequence":"additional","affiliation":[{"name":"North Lab, Sapporo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaito","family":"Iida","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Fujisawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoko","family":"Yamaoka","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Fujisawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Fujisawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumiko","family":"Kagawa","sequence":"additional","affiliation":[{"name":"North Lab, Sapporo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0099-7974","authenticated-orcid":true,"given":"Kazushi","family":"Asano","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Fujisawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"issue":"5","key":"B1","series-title":"Vet Pathol","first-page":"553","article-title":"Canine hepatic neoplasms: a clinicopathologic study","volume":"17","author":"Patnaik AK","year":"1980","unstructured":"Patnaik AK, Hurvitz AI, Lieberman PH. 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