{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:19:07Z","timestamp":1787771947889,"version":"build-2784847793"},"reference-count":30,"publisher":"American Veterinary Medical Association (AVMA)","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2026,8,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"sc_a1\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the efficacy of synthetically derived activated carbon hemoperfusion (cHP) by measuring serum meloxicam concentration in dogs with meloxicam toxicosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a2\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>5 dogs with meloxicam overdose that underwent cHP at 3 teaching hospitals between January 2023 and March 2026 were identified. Dogs that had serum meloxicam concentrations measured were included. For case 1, in-series cHP and hemodialysis were performed. Based on case 1 data, standalone cHP was used for cases 2 to 5. Serum meloxicam concentration was measured via ultra-performance liquid chromatography\u2013tandem mass spectrometry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a3\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Median ingested meloxicam dose was 16.7 mg\/kg (range, 1.4 to 168.8). Median blood volumes processed were 2 L\/kg (range, 1.36 to 2.56) over 2.2 hours (range, 1.5 to 2.6). During cHP, meloxicam half-life was 0.4 to 1 hour versus 5.1 to 16.6 hours post-cHP, and median clearance was 6.52 mL\/kg\/min (range, 3.81 to 10.42) versus 0.49 mL\/kg\/min post-cHP (range, 0.22 to 0.72). Median extracorporeal elimination constant from 5 dogs was 1.24 (range, 0.68 to 1.95), 13.8 times faster than the intrinsic elimination constant of 0.09 from 3 dogs (range, 0.04 to 0.14). After cHP, a rebound phenomenon (47.2% increase, approximately 5 hours later) was noted in 3 dogs. All dogs were discharged in 72 hours, with 1 dog developing International Renal Interest Society Grade II acute kidney injury during hospitalization that recovered with supportive care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a4\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Carbon hemoperfusion markedly reduced serum meloxicam concentrations in dogs with meloxicam toxicosis and substantially shortened meloxicam half-life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a5\">\n                    <jats:title>Clinical Relevance<\/jats:title>\n                    <jats:p>Dogs that underwent timely cHP had excellent short-term outcomes, and cHP should be considered in dogs with high-dose meloxicam ingestion.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2460\/ajvr.26.06.0265","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T18:21:46Z","timestamp":1787768506000},"page":"1-9","source":"Crossref","is-referenced-by-count":0,"title":["Carbon hemoperfusion markedly reduces serum meloxicam concentrations in dogs with meloxicam toxicosis"],"prefix":"10.2460","author":[{"given":"Pei-Tsz","family":"Shin","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijie","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsofia","family":"Vigh","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyler E.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroko","family":"Enomoto","sequence":"additional","affiliation":[{"name":"Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Ueda","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5116-4043","authenticated-orcid":true,"given":"Jacob M.","family":"Wolf","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine E.","family":"Langston","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3150-591X","authenticated-orcid":true,"given":"Jiwoong","family":"Her","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC"},{"name":"Veterinary Emergency Medicine, Department of Veterinary Clinical Science, College of Veterinary Medicine, Research Institute for Veterinary Science, Seoul National University, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"issue":"4","key":"B1","series-title":"Vet Anaesth Analg","first-page":"184","article-title":"Comparison of carprofen and meloxicam for 72 hours following ovariohysterectomy in dogs","volume":"32","author":"Leece EA","year":"2005","unstructured":"Leece EA, Brearley JC, Harding EF. 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