{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:54:52Z","timestamp":1791392092534,"version":"4.3.3"},"reference-count":26,"publisher":"American Veterinary Medical Association (AVMA)","license":[{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2026,8,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"sc_a1\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare baclofen removal by 5 devices across 3 modalities\u2014intermittent hemodialysis (IHD) with low- and high-efficiency dialyzers, prolonged intermittent renal replacement therapy (PIRRT), and 2 hemoperfusion (HP) devices\u2014in ex vivo equine blood. We hypothesized that IHD would be the most effective in baclofen elimination.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a2\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Heparinized equine whole blood was spiked with reference baclofen and treated with low-efficiency IHD, high-efficiency IHD, PIRRT, carbon HP, polymer HP, and control. Each modality ran for 2 hours, targeting 20 times the assigned blood volume. Plasma baclofen was measured by UPLC-MS-MS at baseline and every 20 minutes. Elimination rate constants (\n                      <jats:italic>k<\/jats:italic>\n                      ), reduction ratios, and extraction ratios were calculated from duplicate runs from April 29 through May 2, 2026.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a3\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Baclofen was eliminated the fastest by IHD (\n                      <jats:italic>k<\/jats:italic>\n                      , almost equal to 2.7 h\n                      <jats:sup>\u22121<\/jats:sup>\n                      for both dialyzers; half-life, almost equal to 15 minutes), then PIRRT (\n                      <jats:italic>k<\/jats:italic>\n                      , 2.3 h\n                      <jats:sup>\u22121<\/jats:sup>\n                      ), and most slowly by HP (1.7 and 1.3 h\n                      <jats:sup>\u22121<\/jats:sup>\n                      for carbon HP and polymer HP). Between-run variability was lowest for PIRRT (coefficient of variation, 6%) and highest for carbon HP (coefficient of variation, 77%). Reduction ratios were 99.4% (both IHD), 98.9% (PIRRT), 92.7% (polymer HP), and 89.2% (carbon HP).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a4\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>All modalities substantially reduced baclofen in equine blood ex vivo. Based on the elimination rate constant, IHD was the most effective modality for baclofen elimination.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a5\">\n                    <jats:title>Clinical Relevance<\/jats:title>\n                    <jats:p>Intermittent hemodialysis achieves the most rapid removal. In vivo studies are warranted to compare the performance and efficacy of each modality across clinical settings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2460\/ajvr.26.06.0267","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:12:11Z","timestamp":1791389531000},"page":"1-10","source":"Crossref","is-referenced-by-count":0,"title":["Intermittent hemodialysis yields the highest baclofen elimination among 5 extracorporeal devices in equine whole blood ex vivo"],"prefix":"10.2460","author":[{"given":"Zsofia","family":"Vigh","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carley-Martin","family":"Macfarlane","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James L.","family":"Yeatts","sequence":"additional","affiliation":[{"name":"Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Baynes","sequence":"additional","affiliation":[{"name":"Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lexi S.","family":"Land","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Ueda","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3150-591X","authenticated-orcid":true,"given":"Jiwoong","family":"Her","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC"},{"name":"Veterinary Emergency Medicine, Department of Veterinary Clinical Science, College of Veterinary Medicine, Research Institute for Veterinary Science, Seoul National University, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"B1","year":"2026","unstructured":"Baclofen. 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