{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T13:04:38Z","timestamp":1789391078016,"version":"build-2803163510"},"reference-count":30,"publisher":"American Veterinary Medical Association (AVMA)","license":[{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2026,9,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"sc_a1\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine whether some cats with epilepsy and temporal lobe epilepsy (TLE)-like seizures have dentate gyrus neuropathologic changes consistent with TLE, including hilar neuron loss and mossy fiber sprouting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a2\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Postmortem hippocampal tissue from 5 cats with a history of seizures and 6 control cats was evaluated. Nissl-stained sections were used to estimate hilar neuron populations within the dentate gyrus by optical fractionator stereology. Timm-stained sections were scored by masked investigators to assess mossy fiber sprouting. Hippocampi from epileptic cats were evaluated bilaterally, and findings were compared with control cats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a3\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Mean hilar neuron counts were lower in epileptic cats than controls, although this difference was not statistically significant. Two epileptic cats had hippocampal hilar neuron counts more than 2 SDs below the control mean. Mean Timm scores were higher in epileptic cats than controls, and 2 epileptic cats had mossy fiber sprouting scores more than 2 SDs above the control mean. One epileptic cat had both marked left-sided hilar neuron loss and severe mossy fiber sprouting, greatest in the left hippocampus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a4\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The study found that 1 epileptic cat with TLE-like seizures had dentate gyrus neuropathologic changes resembling those described in TLE in humans and other animal models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a5\">\n                    <jats:title>Clinical Relevance<\/jats:title>\n                    <jats:p>These findings support naturally occurring feline TLE as a potential clinical entity, and antemortem diagnostics should be investigated to identify these cats for advanced treatment options, such as surgical or laser ablation of the affected hippocampus.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2460\/ajvr.26.06.0275","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T12:27:31Z","timestamp":1789388851000},"page":"1-7","source":"Crossref","is-referenced-by-count":0,"title":["Evidence of neuronal loss and granule cell axon reorganization in the dentate gyrus of cats with temporal lobe epilepsy-like seizures"],"prefix":"10.2460","author":[{"given":"Kristin","family":"Baert","sequence":"first","affiliation":[{"name":"Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Majinski","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue","family":"Osting","sequence":"additional","affiliation":[{"name":"Department of Neurology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"DiPaola","sequence":"additional","affiliation":[{"name":"Pet Emergency and Specialty Center of Marin, San Rafael, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1627-1799","authenticated-orcid":true,"given":"Paul","family":"Buckmaster","sequence":"additional","affiliation":[{"name":"Department of Comparative Medicine, School of Medicine, Stanford University, Stanford, CA"},{"name":"Department of Neurology and Neurological Sciences, School of Medicine, Stanford University, Stanford, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5009-2546","authenticated-orcid":true,"given":"Starr","family":"Cameron","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"issue":"10","key":"B1","series-title":"J Am Vet Med Assoc","first-page":"1591","article-title":"Etiologic classification of seizures, signalment, clinical signs, and outcome in cats with seizure disorders: 91 cases (2000\u20132004)","volume":"233","author":"Schriefl S","year":"2008","unstructured":"Schriefl S, Steinberg TA, Matiasek K, Ossig A, Fenske N, Fischer A. 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