{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:01:45Z","timestamp":1790704905906,"version":"4.1.0"},"reference-count":46,"publisher":"American Veterinary Medical Association (AVMA)","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2026,9,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"sc_a1\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Liposomal local anesthetics have been shown to extend analgesia duration and improve pain scores dose-dependently in horses. Our objective was to assess concurrent impact on systemic inflammatory markers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a2\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>18 mares (age, 2 to 20 years) with normal ovarian anatomy were enrolled. Laparoscopic bilateral ovariectomies were performed standing with sedation. Local analgesia was: 80 mL bupivacaine hydrochloride (BHCl; n = 6), 30 mL 0.75% BHCl + 20 mL (low-dose) liposomal bupivacaine (LB) expanded to 80 mL with saline (LB20, n = 6), or 30 mL 0.75% BHCl + 40 mL (high-dose) LB expanded to equal volume around incision sites and mesovarium prior to ovariectomy (LB40, n = 6). Whole blood samples were obtained (0, 0.5, 1, 2, 4, 8, 24, 48, and 72 hours), and plasma was separated. Serum amyloid A (SAA) and 23 cytokines were quantified via commercially available kits and multiplex immunoassay, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a3\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>SAA increased postoperatively from 24 to 72 hours (548.11 \u00b1 726.84, 957.76 \u00b1 1,006.62, and 841.18 \u00b1 953.4, respectively). Serum amyloid A was lower in the LB40 group versus the LB20 group at 48 hours (303 \u00b1 347.74 vs 773.17 \u00b1 733.19) and 72 hours (439.67 \u00b1 461.53 vs 951.6 \u00b1 1,052.4). Cytokine concentrations were quantifiable for 14 cytokines; differences between groups were seen for eotaxin, granulocyte colony-stimulating factor, and IL-8. No group had consistently higher or lower values.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a4\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>High-dose LB suppressed the systemic inflammatory response, resulting in lower SAA postoperatively following ovariectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sc_a5\">\n                    <jats:title>Clinical Relevance<\/jats:title>\n                    <jats:p>Infiltration of extended-duration local anesthetics decreased inflammatory responses postoperatively.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2460\/ajvr.26.08.0341","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:53:59Z","timestamp":1790704439000},"page":"1-9","source":"Crossref","is-referenced-by-count":0,"title":["Liposomal bupivacaine local analgesia reduces systemic inflammatory responses following equine laparoscopic surgery"],"prefix":"10.2460","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1767-3837","authenticated-orcid":true,"given":"Lauren","family":"Luedke","sequence":"first","affiliation":[{"name":"Orthopedic Research Center, Translational Medicine Institute, Colorado State University, Fort Collins, CO"},{"name":"Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3569-8718","authenticated-orcid":true,"given":"Alexandria","family":"Clark","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2246-9742","authenticated-orcid":true,"given":"Dean A.","family":"Hendrickson","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3507-1450","authenticated-orcid":true,"given":"Luke","family":"Bass","sequence":"additional","affiliation":[{"name":"Orthopedic Research Center, Translational Medicine Institute, Colorado State University, Fort Collins, CO"},{"name":"Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Kawahisa-Piquini","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6602-102X","authenticated-orcid":true,"given":"Renata","family":"Impastato","sequence":"additional","affiliation":[{"name":"Orthopedic Research Center, Translational Medicine Institute, Colorado State University, Fort Collins, CO"},{"name":"Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO"},{"name":"Immunotherapy Research Laboratory, Translational Medicine Institute, Colorado State University, Fort Collins, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3513-6480","authenticated-orcid":true,"given":"Isabella","family":"Sabino","sequence":"additional","affiliation":[{"name":"Orthopedic Research Center, Translational Medicine Institute, Colorado State University, Fort Collins, CO"},{"name":"Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO"},{"name":"Immunotherapy Research Laboratory, Translational Medicine Institute, Colorado State University, Fort Collins, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6413-9517","authenticated-orcid":true,"given":"Lyndah","family":"Chow","sequence":"additional","affiliation":[{"name":"Orthopedic Research Center, Translational Medicine Institute, Colorado State University, Fort Collins, CO"},{"name":"Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO"},{"name":"Immunotherapy Research Laboratory, Translational Medicine Institute, Colorado State University, Fort Collins, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5488-9464","authenticated-orcid":true,"given":"Steven","family":"Dow","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO"},{"name":"Immunotherapy Research Laboratory, Translational Medicine Institute, Colorado State University, Fort Collins, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4990-5006","authenticated-orcid":true,"given":"Lynn M.","family":"Pezzanite","sequence":"additional","affiliation":[{"name":"Orthopedic Research Center, Translational Medicine Institute, Colorado State University, Fort Collins, CO"},{"name":"Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO"},{"name":"Immunotherapy Research Laboratory, Translational Medicine Institute, Colorado State University, Fort Collins, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3522-5587","authenticated-orcid":true,"given":"Gregg M.","family":"Griffenhagen","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"issue":"2","key":"B1","series-title":"Surg","first-page":"362","article-title":"Routine clinical markers of the magnitude of the systemic inflammatory response after elective operation: a systematic review","volume":"157","author":"Watt D","year":"2015","unstructured":"Watt D, Horgan P, McMillian D. 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