{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T15:25:18Z","timestamp":1770218718209,"version":"3.49.0"},"reference-count":39,"publisher":"American Veterinary Medical Association (AVMA)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Objective\u2014<\/jats:bold>To measure 11-dehydro-thromboxane B<jats:sub>2<\/jats:sub> (11-dTXB<jats:sub>2<\/jats:sub>) in urine of healthy control dogs, dogs undergoing ovariohysterectomy, and dogs with gastric dilatation-volvulus (GDV) and assess the relationship between urinary 11-dTXB<jats:sub>2<\/jats:sub> concentrations in dogs with GDV and postoperative outcomes.<\/jats:p>\n<jats:p><jats:bold>Sample Population\u2014<\/jats:bold>Urine samples from 15 nonsurgical control dogs, 12 surgical control dogs, and 32 dogs with GVD.<\/jats:p>\n<jats:p><jats:bold>Procedure\u2014<\/jats:bold>Urine samples were obtained from healthy pet dogs (ie, nonsurgical control dogs), dogs undergoing ovariohysterectomy at anesthetic induction and 1 hour following surgery (ie, surgical control dogs), and dogs with GDV at hospital admission and 1 hour following surgical derotation of the stomach (ie, GDV dogs). Urinary 11-dTXB<jats:sub>2<\/jats:sub> concentrations were determined with an ELISA and normalized to urinary creatinine (Cr) concentrations by calculation of the 11-dTXB<jats:sub>2<\/jats:sub> -to-Cr ratio. Differences in median 11-dTXB<jats:sub>2<\/jats:sub> -to-Cr ratios among dogs and before and after surgery were analyzed.<\/jats:p>\n<jats:p><jats:bold>Results\u2014<\/jats:bold>Urinary 11-dTXB<jats:sub>2<\/jats:sub>-to-Cr ratios did not differ between nonsurgical control dogs and surgical control dogs before or after surgery. Urinary 11-dTXB<jats:sub>2<\/jats:sub>-to-Cr ratios were significantly higher in GDV dogs at the time of hospital admission and 1 hour after surgery, compared with those of nonsurgical control dogs. Postoperative urine samples from GDV dogs had significantly higher 11-dTXB<jats:sub>2<\/jats:sub>-to-Cr ratios than postoperative urine samples from surgical control dogs. Median urinary 11-dTXB<jats:sub>2<\/jats:sub>-to-Cr ratios increased significantly in GDV dogs that developed postoperative complications.<\/jats:p>\n<jats:p><jats:bold>Conclusions and Clinical Relevance\u2014<\/jats:bold>Urinary 11-dTXB<jats:sub>2<\/jats:sub> concentration is increased in GDV dogs at the time of hospital admission and after surgical derotation of the stomach, compared with that of healthy dogs. An increased urinary 11-dTXB<jats:sub>2<\/jats:sub>-to-Cr ratio following surgery is associated with an increased incidence of postoperative complications in dogs with GDV.<\/jats:p>","DOI":"10.2460\/ajvr.67.1.78","type":"journal-article","created":{"date-parts":[[2006,1,20]],"date-time":"2006-01-20T22:24:51Z","timestamp":1137795891000},"page":"78-83","source":"Crossref","is-referenced-by-count":21,"title":["Measurement of urinary 11-dehydro-thromboxane B2 excretion in dogs with gastric dilatation-volvulus"],"prefix":"10.2460","volume":"67","author":[{"given":"Wendy I.","family":"Baltzer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maureen A.","family":"McMichael","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig G.","family":"Ruaux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Noaker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rg M.","family":"Steiner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Clin Haematol","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/S0308-2261(18)30018-3","article-title":"Arachidonate metabolism in blood cells and the vessel wall","volume":"15","author":"Moncada","year":"1986"},{"key":"ref2","series-title":"J Pharmacol Exp Ther","first-page":"1037","article-title":"Alterations in thromboxane synthase and thromboxane A2 receptors in experimental alcoholic liver disease","volume":"282","author":"Nanji","year":"1997"},{"key":"ref3","series-title":"Hypertension","first-page":"III86","article-title":"Endothelium-derived vasoactive factors: II. 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