{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T16:03:05Z","timestamp":1780761785570,"version":"3.54.1"},"reference-count":27,"publisher":"American Veterinary Medical Association (AVMA)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Objective<\/jats:bold>\u2014To investigate the effects of buprenorphine on cardiopulmonary variables and on abdominal auscultation scores in horses.<\/jats:p>\n<jats:p><jats:bold>Animals<\/jats:bold>\u20146 healthy adult horses.<\/jats:p>\n<jats:p><jats:bold>Procedures<\/jats:bold>\u2014Horses were restrained in stocks and allocated to 2 treatments in a randomized crossover design, with 1-week intervals between each treatment. Saline (0.9% NaCl) solution was administered IV as a control, whereas buprenorphine (10 \u03bcg\/kg, IV) was administered to the experimental group. Cardiopulmonary data were collected for 120 minutes after buprenorphine or saline solution administration. Abdominal auscultation scores were monitored for 2 and 12 hours after drug administration in the control and experimental groups, respectively.<\/jats:p>\n<jats:p><jats:bold>Results<\/jats:bold>\u2014Following control treatment, horses remained calm while restrained in the stocks and no significant changes in cardiopulmonary variables were observed throughout the study. Buprenorphine administration caused excitatory phenomena (restlessness and head shaking). Heart rate, cardiac index, and arterial blood pressure were significantly increased after buprenorphine administration until the end of the observational period (120 minutes). Minimal changes were found in arterial blood gas tensions. Abdominal auscultation scores decreased significantly from baseline for 4 hours after buprenorphine administration.<\/jats:p>\n<jats:p><jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014 Buprenorphine induced excitement and hemodynamic stimulation with minimal changes in arterial blood gas tensions. These effects may impact the clinical use of buprenorphine in horses. Further studies are indicated to investigate the effects of buprenorphine on gastrointestinal motility and fecal output.<\/jats:p>","DOI":"10.2460\/ajvr.67.10.1675","type":"journal-article","created":{"date-parts":[[2006,10,2]],"date-time":"2006-10-02T13:49:29Z","timestamp":1159796969000},"page":"1675-1680","source":"Crossref","is-referenced-by-count":37,"title":["Cardiopulmonary effects of buprenorphine in horses"],"prefix":"10.2460","volume":"67","author":[{"given":"Adriano B.","family":"Carregaro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco J. Teixeira","family":"Neto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzane L.","family":"Beier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stelio P. 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Characteristics of the locomotor effects of fentanyl and apomorphine","volume":"3","author":"Tobin","year":"1979"},{"key":"ref7","series-title":"J Equine Med Surg","first-page":"102","article-title":"Pharmacology review: actions of central stimulant drugs in the horse II","volume":"3","author":"Tobin","year":"1979"},{"key":"ref8","series-title":"Can J Vet Res","first-page":"106","article-title":"Evaluation of the interaction of mu and kappa opioid agonists on locomotor behavior in the horse","volume":"57","author":"Mama","year":"1993"},{"key":"ref9","series-title":"Int J Clin Pract Suppl","first-page":"3","article-title":"Buprenorphine: new pharmacological aspects","volume":"133","author":"Cowan","year":"2003"},{"key":"ref10","series-title":"Br J Pharmacol","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1111\/j.1476-5381.1981.tb10473.x","article-title":"In vivo receptor binding of the opiate partial agonist, buprenorphine, correlated with its agonistic and antagonistic actions","volume":"74","author":"Dum","year":"1981"},{"key":"ref11","series-title":"Anaesthesia","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1111\/j.1365-2044.1980.tb04993.x","article-title":"Haemodynamic changes following buprenorphine and morphine","volume":"35","author":"Scott","year":"1980"},{"key":"ref12","series-title":"Am J Vet Res","first-page":"1280","article-title":"Cardiovascular effects of buprenorphine in anesthetized dogs","volume":"58","author":"Martinez","year":"1997"},{"key":"ref13","series-title":"Vet Rec","first-page":"63","article-title":"Combined use of sedatives and opiates in horses","volume":"21","author":"Nolan","year":"1984"},{"key":"ref14","series-title":"Am J Vet Res","first-page":"1287","article-title":"Effects of buprenorphine on cardiovascular and pulmonary function in clinically normal horses and horses with chronic obstructive pulmonary disease","volume":"59","author":"Sz\u00f6ke","year":"1998"},{"key":"ref15","series-title":"Vet Anaesth Analg","first-page":"72","article-title":"Hormonal, metabolic and physiological effects of laparoscopic surgery using a detomidine-buprenorphine combination in standing horses","volume":"30","author":"van Dijk","year":"2003"},{"key":"ref16","series-title":"J Vet Anaesth","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1111\/j.1467-2995.1997.tb00262.x","article-title":"The effect of glycopyrrolate on heart rate and intestinal motility in conscious horses","volume":"24","author":"Singh","year":"1997"},{"key":"ref17","series-title":"Am J Vet Res","first-page":"1632","article-title":"Cardiopulmonary effects of narcotic agonists and a partial agonist in horses","volume":"39","author":"Muir","year":"1978"},{"key":"ref18","series-title":"Am J Vet Res","first-page":"217","article-title":"Effects of butorphanol, flunixim, levorphanol, morphine, and xylazine in ponies","volume":"45","author":"Kalpravidh","year":"1984"},{"key":"ref19","series-title":"Am J Vet Res","first-page":"2081","article-title":"Visceral analgesia: effects of xylazine, butorphanol, meperidine, and pentazocine in horses","volume":"46","author":"Muir","year":"1985"},{"key":"ref20","series-title":"J Vet Intern Med","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1111\/j.1939-1676.1991.tb00936.x","article-title":"Hemodynamic effects of atropine, dobutamine, nitroprusside, phenylephrine, and propranolol in conscious horses","volume":"5","author":"Hinchcliff","year":"1991"},{"key":"ref21","series-title":"Veterinary physiology","first-page":"180","article-title":"The heart as a pump","author":"Stephenson","year":"1997"},{"key":"ref22","series-title":"J Med","first-page":"225","article-title":"Comparative gastrointestinal and biliary tract effects of morphine and butorphanol (Stadol)","volume":"10","author":"Roebel","year":"1979"},{"key":"ref23","series-title":"Am J Vet Res","doi-asserted-by":"publisher","first-page":"183","DOI":"10.2460\/ajvr.2001.62.183","article-title":"Pharmacokinetics and adverse effects of butorphanol administered by single intravenous injection or continuous intravenous infusion in horses","volume":"62","author":"Sellon","year":"2001"},{"key":"ref24","series-title":"Vet Anaesth Analg","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1046\/j.1467-2995.2003.00092.x","article-title":"Problems associated with perioperative morphine in horses: a retrospective case analysis","volume":"30","author":"Mircica","year":"2003"},{"key":"ref25","series-title":"Vet Rec","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1136\/vr.155.11.321","article-title":"Retrospective study of the risk factors and prevalence of colic in horses after orthopaedic surgery","volume":"155","author":"Senior","year":"2004"},{"key":"ref26","series-title":"Br J 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