{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T02:58:50Z","timestamp":1770433130669,"version":"3.49.0"},"reference-count":35,"publisher":"American Veterinary Medical Association (AVMA)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Objective<\/jats:bold>\u2014To evaluate effects of injection with a nonsteroidal anti-inflammatory drug (NSAID) followed by oral administration of an NSAID on the gastrointestinal tract (GIT) of healthy dogs.<\/jats:p>\n<jats:p><jats:bold>Animals<\/jats:bold>\u20146 healthy Walker Hounds.<\/jats:p>\n<jats:p><jats:bold>Procedures<\/jats:bold>\u2014In a randomized, crossover design, dogs were administered 4 treatments consisting of an SC injection of an NSAID or control solution (day 0), followed by oral administration of an NSAID or inert substance for 4 days (days 1 through 4). Treatment regimens included carprofen (4 mg\/kg) followed by inert substance; saline (0.9% NaCl) solution followed by deracoxib (4 mg\/kg); carprofen (4 mg\/kg) followed by carprofen (4 mg\/kg); and carprofen (4 mg\/kg) followed by deracoxib (4 mg\/kg). Hematologic, serum biochemical, and fecal evaluations were conducted weekly, and clinical scores were obtained daily. Endoscopy of the GIT was performed before and on days 1, 2, and 5 for each treatment. Lesions were scored by use of a 6-point scale.<\/jats:p>\n<jats:p><jats:bold>Results<\/jats:bold>\u2014No significant differences existed for clinical data, clinicopathologic data, or lesion scores in the esophagus, cardia, or duodenum. For the gastric fundus, antrum, and lesser curvature, an effect of time was observed for all treatments, with lesions worsening from before to day 2 of treatments but improving by day 5.<\/jats:p>\n<jats:p><jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Sequential administration of NSAIDs in this experiment did not result in clinically important gastroduodenal ulcers. A larger study to investigate the effect of sequential administration of NSAIDs for longer durations and in dogs with signs of acute and chronic pain is essential to substantiate these findings.<\/jats:p>","DOI":"10.2460\/ajvr.67.10.1794","type":"journal-article","created":{"date-parts":[[2006,10,2]],"date-time":"2006-10-02T13:49:29Z","timestamp":1159796969000},"page":"1794-1801","source":"Crossref","is-referenced-by-count":19,"title":["Effect of short-term sequential administration of nonsteroidal anti-inflammatory drugs on the stomach and proximal portion of the duodenum in healthy dogs"],"prefix":"10.2460","volume":"67","author":[{"given":"Kristy L.","family":"Dowers","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha R.","family":"Uhrig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khursheed R.","family":"Mama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James S.","family":"Gaynor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter W.","family":"Hellyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Vet Clin North Am Small Anim Pract","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1016\/S0195-5616(08)70007-X","article-title":"Nonsteroidal anti-inflammatory analgesics. 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Complementary roles for COX-2 inhibitors and proton pump inhibitors","volume":"52","author":"Hawkey","year":"2003"},{"key":"ref7","series-title":"N Engl J Med","doi-asserted-by":"publisher","first-page":"1888","DOI":"10.1056\/NEJM199906173402407","article-title":"Gastrointestinal toxicity of non-steroidal anti-inflammatory drugs","volume":"340","author":"Wolfe","year":"1999"},{"key":"ref8","series-title":"Proc Natl Acad Sci USA","doi-asserted-by":"publisher","first-page":"7563","DOI":"10.1073\/pnas.96.13.7563","article-title":"Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis","volume":"96","author":"Warner","year":"1999"},{"key":"ref9","series-title":"J Vet Intern Med","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1111\/j.1939-1676.2005.tb02741.x","article-title":"The coxib NSAIDs: potential clinical and pharmacologic importance in veterinary medicine","volume":"19","author":"Bergh","year":"2005"},{"key":"ref10","series-title":"J Small Anim Pract","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1111\/j.1748-5827.1998.tb03748.x","article-title":"Endoscopy of the gastroduodenal mucosa after carprofen, meloxicam and ketoprofen administration in dogs","volume":"39","author":"Forsyth","year":"1998"},{"key":"ref11","series-title":"J Vet Intern Med","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1111\/j.1939-1676.1999.tb01465.x","article-title":"The gastroduodenal effects of buffered aspirin, carprofen, and etodolac in healthy dogs","volume":"13","author":"Reimer","year":"1999"},{"key":"ref12","series-title":"Am J Vet Res","doi-asserted-by":"publisher","first-page":"1755","DOI":"10.2460\/ajvr.2001.62.1755","article-title":"In vitro effects of cyclooxygenase inhibitors in whole blood of horses, dogs, and cats","volume":"62","author":"Brideau","year":"2001"},{"key":"ref13","series-title":"Adv Exp Med Biol","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1007\/978-1-4899-1810-9_27","article-title":"Mechanism of action of anti-inflammatory drugs","volume":"433","author":"Vane","year":"1997"},{"key":"ref14","series-title":"Am J Vet Res","doi-asserted-by":"publisher","first-page":"802","DOI":"10.2460\/ajvr.2000.61.802","article-title":"In vitro effects of nonsteroidal anti-inflammatory drugs on cyclooxygenase activity in dogs","volume":"61","author":"Kay-Mugford","year":"2000"},{"key":"ref15","series-title":"J Am Vet Med Assoc","first-page":"1493","article-title":"Use of carprofen for the treatment of pain and inflammation in dogs","volume":"210","author":"Fox","year":"1997"},{"key":"ref16","series-title":"Vet Rec","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1136\/vr.150.22.684","article-title":"Clinical efficacy and pharmacokinetics of carprofen in the treatment of dogs with osteoarthritis","volume":"150","author":"Lipscomb","year":"2002"},{"key":"ref17","series-title":"Compend Contin Educ Small Anim Pract","first-page":"452","article-title":"Deracoxib","volume":"25","author":"Smith","year":"2003"},{"key":"ref18","series-title":"J Am Vet Med Assoc","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.2460\/javma.2005.227.1112","article-title":"Gastrointestinal tract perforation in dogs treated with a selective cyclooxygenase-2 inhibitor: 29 cases (2002\u20132003)","volume":"227","author":"Lascelles","year":"2005"},{"key":"ref19","series-title":"A multicenter clinical study of the effect of deracoxib, a COX-2 selective drug, on postoperative analgesia associated with cranial cruciate ligament surgery in dogs. FDA Freedom of Information Summary","author":"Millis","year":"2002"},{"key":"ref20","series-title":"Vet Ther","first-page":"453","article-title":"Effect of deracoxib, a new COX-2 inhibitor, on the prevention of lameness induced by chemical synovitis in dogs","volume":"3","author":"Millis","year":"2002"},{"key":"ref21","series-title":"Am J Vet Res","doi-asserted-by":"publisher","first-page":"1369","DOI":"10.2460\/ajvr.2003.64.1369","article-title":"Endoscopic evaluation of the gastroduodenal mucosa to determine the safety of short-term concurrent administration of meloxicam and dexamethasone in healthy dogs","volume":"64","author":"Boston","year":"2003"},{"key":"ref22","series-title":"Microsc Res Tech","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1002\/jemt.1102","article-title":"Classic NSAID and selective cyclooxygenase (COX)-1 and COX-2 inhibitors in healing of chronic gastric ulcers","volume":"53","author":"Brzozowski","year":"2001"},{"key":"ref23","series-title":"Arch Biochem Biophys","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1006\/abbi.1997.0572","article-title":"Levels of cyclooexygenase-1 and -2 mRNA expressions at various stages of acute gastric injury induced by ischemia-reperfusion in rats","volume":"352","author":"Kishimoto","year":"1998"},{"key":"ref24","series-title":"Gastroenterology","first-page":"327","article-title":"Gastric adaption: studies in humans during continuous aspirin administration","volume":"95","author":"Graham","year":"1988"},{"key":"ref25","series-title":"J Pharmacol Exp Ther","first-page":"1160","article-title":"Adaptive gastric cytoprotection is mediated by prostaglandin EP1 receptors: a study using rats and knockout mice","volume":"297","author":"Takeuchi","year":"2001"},{"key":"ref26","series-title":"Circ Res","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1161\/01.RES.40.6.590","article-title":"Contribution of prostaglandins to the renal circulation in conscious, anesthetized, and laparotomized dogs","volume":"40","author":"Terragno","year":"1977"},{"key":"ref27","series-title":"Am J Med","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/0002-9343(91)90189-5","article-title":"Stress ulcer prophylaxis in the critically ill: a meta-analysis","volume":"91","author":"Cook","year":"1991"},{"key":"ref28","series-title":"Am J Med","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1016\/0002-9343(84)90286-9","article-title":"Prospective evaluation of the risk of upper gastrointestinal bleeding after admission to a medical intensive care unit","volume":"76","author":"Shuster","year":"1984"},{"key":"ref29","series-title":"Equine Vet J","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1111\/j.2042-3306.1996.tb03107.x","article-title":"Factors associated with gastric lesions in Thoroughbred horses","volume":"28","author":"Murray","year":"1996"},{"key":"ref30","series-title":"J Vet Intern Med","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1111\/j.1939-1676.2003.tb02453.x","article-title":"Prevalence of gastric lesions in racing Alaskan sled dogs","volume":"17","author":"Davis","year":"2003"},{"key":"ref31","series-title":"Gastroenterology","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/S0016-5085(85)80181-5","article-title":"Role of blood flow in gastric and duodenal mucosal injury in the rat","volume":"88","author":"Leung","year":"1985"},{"key":"ref32","series-title":"J Physiol Biochem","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1007\/BF03179794","article-title":"Effect of psychogenic stress on gastrointestinal function","volume":"56","author":"Martinez-Augustin","year":"2000"},{"key":"ref33","series-title":"J Vet Intern Med","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1111\/j.1939-1676.1989.tb00863.x","article-title":"Gastroduodenal ulceration in dogs: retrospective study of 43 cases and literature 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