{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T23:44:03Z","timestamp":1783035843945,"version":"3.54.6"},"reference-count":28,"publisher":"American Veterinary Medical Association (AVMA)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Objective<\/jats:bold>\u2014To determine the effects of meloxicam and butorphanol on minimum alveolar concentration of isoflurane (MAC<jats:sub>ISO<\/jats:sub>) in rabbits.<\/jats:p>\n<jats:p><jats:bold>Animals<\/jats:bold>\u201410 healthy young adult female rabbits.<\/jats:p>\n<jats:p><jats:bold>Procedure<\/jats:bold>\u2014Rabbits were anesthetized with isoflurane on 3 occasions in a blinded, randomized complete block design to determine the MAC<jats:sub>ISO<\/jats:sub> associated with administration of meloxicam (0, 0.3, or 1.5 mg\/kg, PO) and butorphanol (0.4 mg\/kg, IV). The MAC<jats:sub>ISO<\/jats:sub> was determined by use of a paw clamp technique as the end-tidal concentration of isoflurane halfway between the values that allowed or inhibited purposeful movement. Rectal temperature, end-tidal CO<jats:sub>2<\/jats:sub> concentration, heart rate, oxygen saturation, and arterial blood pressure were measured to evaluate cardiopulmonary function.<\/jats:p>\n<jats:p><jats:bold>Results<\/jats:bold>\u2014Mean \u00b1 SE MAC<jats:sub>ISO<\/jats:sub> in saline (0.9% NaCl) solution\u2013treated rabbits was 2.49 \u00b1 0.07% and was not significantly different from that associated with administration of meloxicam at 0.3 mg\/kg (2.56 \u00b1 0.07%) or 1.5 mg\/kg (2.66 \u00b1 0.07%). Butorphanol significantly reduced the MAC<jats:sub>ISO<\/jats:sub> to 2.30 \u00b1 0.07% when administered with saline solution alone, 2.27 \u00b1 0.07% when administered with 0.3 mg of meloxicam\/kg, and 2.33 \u00b1 0.07% when administered with 1.5 mg of meloxicam\/kg. The percentage reduction in MAC<jats:sub>ISO<\/jats:sub> was significantly greater for rabbits that received butorphanol and meloxicam at either dose, compared with butorphanol and saline solution.<\/jats:p>\n<jats:p><jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Results indicated that meloxicam does not have a direct isoflurane-sparing effect and does not interfere with the anesthetic-sparing effect of butorphanol in rabbits.<\/jats:p>","DOI":"10.2460\/ajvr.67.5.770","type":"journal-article","created":{"date-parts":[[2006,5,1]],"date-time":"2006-05-01T16:31:51Z","timestamp":1146501111000},"page":"770-774","source":"Crossref","is-referenced-by-count":31,"title":["Effect of meloxicam and butorphanol on minimum alveolar concentration of isoflurane in rabbits"],"prefix":"10.2460","volume":"67","author":[{"given":"Patricia V.","family":"Turner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn L.","family":"Kerr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda J.","family":"Healy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. 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