{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T13:47:33Z","timestamp":1775742453178,"version":"3.50.1"},"reference-count":38,"publisher":"American Veterinary Medical Association (AVMA)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Objective<\/jats:bold>\u2014To determine effects of epidural administration of morphine and buprenorphine on the minimum alveolar concentration of isoflurane in cats.<\/jats:p>\n<jats:p><jats:bold>Animals<\/jats:bold>\u20146 healthy adult domestic shorthair cats.<\/jats:p>\n<jats:p><jats:bold>Procedures<\/jats:bold>\u2014Cats were anesthetized with isoflurane in oxygen. Morphine (100 \u03bcg\/kg diluted with saline [0.9% NaCl] solution to a volume of 0.3 mL\/kg), buprenorphine (12.5 \u03bcg\/kg diluted with saline solution to a volume of 0.3 mL\/kg), or saline solution (0.3 mL\/kg) was administered into the epidural space according to a Latin square design. The minimum alveolar concentration (MAC) of isoflurane was measured in triplicate by use of the tail clamp technique. At least 1 week was allowed between successive experiments.<\/jats:p>\n<jats:p><jats:bold>Results<\/jats:bold>\u2014The MAC of isoflurane was 2.00 \u00b1 0.18%, 2.13 \u00b1 0.11%, and 2.03 \u00b1 0.09% in the morphine, buprenorphine, and saline solution groups, respectively. No significant difference in MAC was detected among treatment groups.<\/jats:p>\n<jats:p><jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014A significant effect of epidural administration of morphine or buprenorphine on the MAC of isoflurane in cats could not be detected. Further studies are needed to establish whether epidural opioid administration has other benefits when administered as a component of general anesthesia in cats.<\/jats:p>","DOI":"10.2460\/ajvr.67.9.1471","type":"journal-article","created":{"date-parts":[[2006,9,1]],"date-time":"2006-09-01T13:56:18Z","timestamp":1157118978000},"page":"1471-1475","source":"Crossref","is-referenced-by-count":30,"title":["Effects of epidural administration of morphine and buprenorphine on the minimum alveolar concentration of isoflurane in cats"],"prefix":"10.2460","volume":"67","author":[{"given":"Bruno H.","family":"Pypendop","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter J.","family":"Pascoe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan E.","family":"Ilkiw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Anesthesia","first-page":"273","article-title":"Intravenous opioid anesthetics","author":"Bailey","year":"2000"},{"key":"ref2","series-title":"Vet J","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1053\/tvjl.2000.0528","article-title":"Epidural analgesia in the dog and cat","volume":"161","author":"Jones","year":"2001"},{"key":"ref3","series-title":"Drug Saf","doi-asserted-by":"publisher","first-page":"173","DOI":"10.2165\/00002018-199819030-00002","article-title":"Adverse effects of opioid agonists and agonistantagonists in anaesthesia","volume":"19","author":"Bowdle","year":"1998"},{"key":"ref4","series-title":"Anaesth Intensive Care","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1177\/0310057X8701500108","article-title":"Epidural and intrathecal opioids","volume":"15","author":"Morgan","year":"1987"},{"key":"ref5","series-title":"Anesthesiology","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1097\/00000542-198409000-00008","article-title":"Intrathecal and epidural administration of opioids","volume":"61","author":"Cousins","year":"1984"},{"key":"ref6","series-title":"Can Vet J","first-page":"650","article-title":"Postoperative urinary retention in a dog following morphine with bupivacaine epidural analgesia","volume":"39","author":"Herperger","year":"1998"},{"key":"ref7","series-title":"Acta Anaesthesiol Scand","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1111\/j.1399-6576.1980.tb01584.x","article-title":"Double-blind, multiple-dose comparison of buprenorphine and morphine in postoperative pain","volume":"24","author":"Tigerstedt","year":"1980"},{"key":"ref8","series-title":"Arzneimittelforschung","first-page":"361","article-title":"Continuous-pluson-demand epidural infusion of buprenorphine versus morphine in postoperative treatment of pain. 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