{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:02:09Z","timestamp":1792454529334,"version":"4.5.0"},"reference-count":29,"publisher":"American Veterinary Medical Association (AVMA)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Objective<\/jats:bold>\n                    \u2014To determine the effects of nonsteroidal anti-inflammatory drugs of various cyclooxygenase selectivities on hemostasis and prostaglandin expression in dogs.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Animals<\/jats:bold>\n                    \u20148 client-owned dogs with clinical signs of osteoarthritis.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Procedures<\/jats:bold>\n                    \u2014Dogs received aspirin (5 mg\/kg, PO, q 12 h), carprofen (4 mg\/kg, PO, q 24 h), deracoxib (2 mg\/kg, PO, q 24 h), and meloxicam (0.1 mg\/kg, PO, q 24 h) for 10 days each, with an interval of at least 14 days between treatments. On days 0 and 10, blood was collected for platelet aggregation assays, thrombelastography, and measurement of lipopolysaccharide-stimulated prostaglandin E\n                    <jats:sub>2<\/jats:sub>\n                    , platelet thromboxane B\n                    <jats:sub>2<\/jats:sub>\n                    (TXB\n                    <jats:sub>2<\/jats:sub>\n                    ), and free serum TXB\n                    <jats:sub>2<\/jats:sub>\n                    and 6-keto-prostaglandin F (PGF)-1\u03b1 concentrations.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results<\/jats:bold>\n                    \u2014Platelet aggregation decreased after treatment with aspirin and carprofen, whereas significant changes from baseline were not detected for the other drugs tested. Thrombelastograms obtained after treatment with carprofen revealed decreased maximum amplitude and \u03b1-angle, suggesting hypocoagulability. Maximum amplitude and coagulation index increased after treatment with deracoxib. Plasma concentrations of prostaglandin E\n                    <jats:sub>2<\/jats:sub>\n                    decreased after treatment with carprofen or deracoxib, and platelet TXB\n                    <jats:sub>2<\/jats:sub>\n                    production increased after treatment with aspirin. Serum concentrations of the prostacyclin metabolite 6-keto-PGF-1\u03b1 did not change significantly after treatment with any of the drugs, although the ratio of free TXB\n                    <jats:sub>2<\/jats:sub>\n                    to 6-keto-PGF-1\u03b1 decreased slightly after treatment with carprofen and increased slightly after treatment with deracoxib.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\n                    \u2014At the dosages tested, treatment with meloxicam affected platelet function minimally in dogs with osteoarthritis. Treatment with carprofen decreased clot strength and platelet aggregation. Clot strength was increased after treatment with deracoxib.\n                  <\/jats:p>","DOI":"10.2460\/ajvr.68.3.251","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T21:24:15Z","timestamp":1172784255000},"page":"251-257","source":"Crossref","is-referenced-by-count":117,"title":["Changes in platelet function, hemostasis, and prostaglandin expression after treatment with nonsteroidal anti-inflammatory drugs with various cyclooxygenase selectivities in dogs"],"prefix":"10.2460","volume":"68","author":[{"given":"Benjamin M.","family":"Brainard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig P.","family":"Meredith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Beth","family":"Callan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven 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