{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:00:09Z","timestamp":1790769609783,"version":"4.1.0"},"reference-count":18,"publisher":"American Veterinary Medical Association (AVMA)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Objective<\/jats:bold>\n                    \u2014To evaluate the efficacy of tiludronate for the treatment of horses with signs of pain associated with lesions of the thoracolumbar vertebral column.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Animals<\/jats:bold>\n                    \u201429 horses with clinical manifestations of pain associated with lesions of the thoracolumbar vertebral column and abnormal radiographic findings indicative of osteoarthritis of the articular processes\u2013synovial intervertebral joints.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Procedures<\/jats:bold>\n                    \u2014Horses were initially examined in accordance with a standardized protocol, which included radiographic, ultrasonographic, and scintigraphic examinations. Fifteen horses were randomly assigned to receive tiludronate (1 mg\/kg, IV, as a slow-rate infusion), and 14 horses received a control substance (day 0). Horses were monitored for the subsequent 120 days. Clinical evaluations were performed on days 60 and 120. Horses that had no evidence of clinical improvement on day 60 were administered tiludronate. Statistical analyses were performed to compare efficacy at day 60, improvement of dorsal flexibility at day 120, and dorsal flexibility before and 60 days after administration of tiludronate.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results<\/jats:bold>\n                    \u2014Horses treated with tiludronate had significant improvement in dorsal flexibility between days 0 and 60, compared with control horses. Clinical improvement in dorsal flexibility was still evident at day 120. The percentage of positive responses was higher in the tiludronate group at 60 days.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\n                    \u2014Tiludronate had efficacy in the treatment of horses with signs of pain induced by osteoarticular lesions of the thoracolumbar vertebral column, causing a significant improvement in dorsal flexibility. Tiludronate may offer a treatment option for the management of horses with intervertebral lesions and the associated pain.\n                  <\/jats:p>","DOI":"10.2460\/ajvr.68.3.329","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T21:24:15Z","timestamp":1172784255000},"page":"329-337","source":"Crossref","is-referenced-by-count":65,"title":["Efficacy of tiludronate in the treatment of horses with signs of pain associated with osteoarthritic lesions of the thoracolumbar vertebral column"],"prefix":"10.2460","volume":"68","author":[{"given":"Virginie","family":"Coudry","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Thibaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Riccio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrice","family":"Audigi\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Didierlaurent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marie","family":"Denoix","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Equine Vet J","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1111\/j.2042-3306.1975.tb03234.x","article-title":"The diagnosis of disease of the horse's back","volume":"7","author":"Jeffcott","year":"1975"},{"key":"ref2","series-title":"Diagnosis and management of lameness in horses","first-page":"509","article-title":"The thoracolumbar spine","author":"Denoix","year":"2003"},{"key":"ref3","series-title":"Adams' lameness in horses","first-page":"1053","article-title":"The thoracolumbar spine","author":"Hendrickson","year":"2002"},{"key":"ref4","series-title":"Equine Vet J","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1111\/j.2042-3306.1980.tb03427.x","article-title":"Disorders of the thoracolumbar spine of the horse\u2014 a survey of 443 cases","volume":"12","author":"Jeffcott","year":"1980"},{"key":"ref5","series-title":"World Equine Vet Assoc","first-page":"99","article-title":"Lesions of the vertebral column in poor performance horses, in Proceedings","author":"Denoix","year":"1999"},{"key":"ref6","series-title":"Vet Clin North Am Equine Pract","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/S0749-0739(17)30168-2","article-title":"Back problems. Radiology and scintigraphy","volume":"15","author":"Weaver","year":"1999"},{"key":"ref7","series-title":"Equine Vet J","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1111\/j.2042-3306.1986.tb03559.x","article-title":"Relationship between spinal biomechanics and pathological changes in the equine thoracolumbar spine","volume":"18","author":"Townsend","year":"1986"},{"key":"ref8","series-title":"Equine Vet J","first-page":"407","article-title":"Tiludronate as a new therapeutic agent in the treatment of navicular disease: a double-blind placebo-controlled clinical trial","volume":"35","author":"Denoix","year":"2003"},{"key":"ref9","series-title":"Vet Clin North Am Equine Pract","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0749-0739(17)30160-8","article-title":"Historical perspective and clinical indications","volume":"15","author":"Jeffcott","year":"1999"},{"key":"ref10","series-title":"Vet Clin North Am Equine Pract","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/S0749-0739(17)30163-3","article-title":"Physical examination of horses with back pain","volume":"15","author":"Martin","year":"1999"},{"key":"ref11","series-title":"Equine Vet J Suppl","first-page":"210","article-title":"Kinematics of the equine back: flexion-extension movements in sound trotting horses","volume":"30","author":"Audigi\u00e9","year":"1999"},{"key":"ref12","series-title":"Equine Vet J","first-page":"707","article-title":"Kinematic evaluation of the back in the sport horse with back pain","volume":"36","author":"Wernnerstrand","year":"2004"},{"key":"ref13","series-title":"Equine locomotion","first-page":"167","article-title":"The neck and back","author":"Denoix","year":"2001"},{"key":"ref14","series-title":"Equine Vet J","first-page":"699","article-title":"Determination of the stiffness of the equine spine","volume":"36","author":"Schlacher","year":"2004"},{"key":"ref15","series-title":"Equine Vet J","first-page":"458","article-title":"Relationship between scintigraphic and radiographic evaluations of spinous processes in the thoracolumbar spine in riding horses without clinical signs of back problems","volume":"36","author":"Erichsen","year":"2004"},{"key":"ref16","series-title":"Skeletal nuclear medicine","first-page":"9","article-title":"Radiopharmaceuticals for bone scanning","author":"Subramanian","year":"1996"},{"key":"ref17","series-title":"Vet Clin North Am Equine Pract","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/S0749-0739(17)30167-0","article-title":"Osseous spinal pathology","volume":"15","author":"Haussler","year":"1999"},{"key":"ref18","series-title":"Vet Clin North Am Equine Pract","first-page":"120","article-title":"The role of subchondral bone in joint disease: a review","volume":"15","author":"Kawcak","year":"1999"}],"container-title":["American Journal of Veterinary Research"],"original-title":[],"link":[{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/ajvr\/68\/3\/ajvr.68.3.329.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/ajvr\/68\/3\/ajvr.68.3.329.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/ajvr\/68\/3\/ajvr.68.3.329.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T07:18:32Z","timestamp":1741331912000},"score":1,"resource":{"primary":{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/ajvr\/68\/3\/ajvr.68.3.329.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3]]},"references-count":18,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.2460\/ajvr.68.3.329","relation":{},"ISSN":["0002-9645"],"issn-type":[{"value":"0002-9645","type":"print"}],"subject":[],"published":{"date-parts":[[2007,3]]}}}