{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T15:30:51Z","timestamp":1770219051007,"version":"3.49.0"},"reference-count":20,"publisher":"American Veterinary Medical Association (AVMA)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Objective<\/jats:bold>\u2014To compare hepatic, pancreatic, and gastric perfusion on dynamic computed tomography (CT) scans of clinically normal dogs with those of dogs with portal vascular anomalies.<\/jats:p>\n<jats:p><jats:bold>Sample Population<\/jats:bold>\u2014Dynamic computed tomography (CT) scans of 10 clinically normal dogs and 21 dogs with portal vascular anomalies.<\/jats:p>\n<jats:p><jats:bold>Procedures<\/jats:bold>\u2014Retrospective analysis of dynamic CT scans. Hepatic arterial perfusion, hepatic portal perfusion, total hepatic perfusion, hepatic perfusion index, gastric perfusion, and pancreatic perfusion were calculated from time attenuation curves.<\/jats:p>\n<jats:p><jats:bold>Results<\/jats:bold>\u2014Mean \u00b1 hepatic arterial perfusion was significantly higher in affected dogs (0.57 \u00b1 0.27 mL\/min\u2022mL<jats:sup>\u22121<\/jats:sup>) than in clinically normal dogs (0.23 \u00b1 0.11 mL\/min\u2022mL<jats:sup>\u22121<\/jats:sup>), and hepatic portal perfusion was significantly lower in affected dogs (0.52 \u00b1 0.47 mL\/min\u2022mL<jats:sup>\u22121<\/jats:sup>) than in clinically normal dogs (1.08 \u00b1 0.45 mL\/min\u2022mL<jats:sup>\u22121<\/jats:sup>). This was reflected in the hepatic perfusion index, which was significantly higher in affected dogs (0.59 \u00b1 0.34), compared with clinically normal dogs (0.19 \u00b1 0.07). Gastric perfusion was significantly higher in dogs with portal vascular anomalies (0.72 \u00b1 0.44 mL\/min\u2022mL<jats:sup>\u22121<\/jats:sup>) than in clinically normal dogs (0.41 \u00b1 0.21 mL\/min\u2022mL<jats:sup>\u22121<\/jats:sup>), but total hepatic perfusion and pancreatic perfusion were not significantly different. Among subgroups, dogs with congenital intrahepatic portosystemic shunts and dogs with arterioportal fistulae had higher hepatic arterial perfusion than did clinically normal dogs. Dogs with congenital intrahepatic portosystemic shunts also had an increase in gastric perfusion and hepatic perfusion index.<\/jats:p>\n<jats:p><jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Hepatic perfusion variables measured on CT scans revealed differences in hemodynamics between clinically normal dogs and those with portal vascular anomalies.<\/jats:p>","DOI":"10.2460\/ajvr.68.9.970","type":"journal-article","created":{"date-parts":[[2007,9,1]],"date-time":"2007-09-01T15:04:33Z","timestamp":1188659073000},"page":"970-974","source":"Crossref","is-referenced-by-count":32,"title":["Dynamic computed tomographic quantitation of hepatic perfusion in dogs with and without portal vascular anomalies"],"prefix":"10.2460","volume":"68","author":[{"given":"Allison L.","family":"Zwingenberger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frances S.","family":"Shofer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"J Vet Med A Physiol Pathol Clin Med","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1111\/j.1439-0442.1986.tb00513.x","article-title":"Some biochemical and physiological data of the Labrador Retriever","volume":"33","author":"Skerritt","year":"1986"},{"key":"ref2","series-title":"Dig Surg","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1159\/000018632","article-title":"Long-term measurement of liver microcirculation in dogs and humans","volume":"15","author":"Kotzampassi","year":"1998"},{"key":"ref3","series-title":"Eur J Radiol","first-page":"256","article-title":"Dynamic CT scanning of the normal canine liver: interpretation of time density curves resulting from an intravenous bolus injection of contrast material","volume":"5","author":"Jaschke","year":"1985"},{"key":"ref4","series-title":"Vet Radiol","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1111\/j.1740-8261.1989.tb00777.x","article-title":"Estimation of portal blood flow using duplex real-time and pulsed Doppler ultrasound imaging in the dog","volume":"30","author":"Kantrowitz","year":"1989"},{"key":"ref5","series-title":"Vet Radiol","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1111\/j.1740-8261.1983.tb00720.x","article-title":"Quantitative hepatic scintigraphy in the dog","volume":"24","author":"Koblik","year":"1983"},{"key":"ref6","series-title":"J Surg Res","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/0022-4804(86)90014-4","article-title":"Hepatic blood flow measurement with inert gas clearance","volume":"41","author":"Mathie","year":"1986"},{"key":"ref7","series-title":"Vet Radiol","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1111\/j.1740-8261.1983.tb00721.x","article-title":"Use of quantitative hepatic scintigraphy to evaluate spontaneous portosystemic shunts in 12 dogs","volume":"24","author":"Koblik","year":"1983"},{"key":"ref8","series-title":"Gastroenterology","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1016\/S0016-5085(82)80124-8","article-title":"Effects of portosystemic shunting on visceral and portal blood flow in the dog","volume":"83","author":"Shatney","year":"1982"},{"key":"ref9","series-title":"Gastroenterology","doi-asserted-by":"publisher","first-page":"1432","DOI":"10.1016\/S0016-5085(19)30496-2","article-title":"Acute and chronic splanchnic blood flow responses to portacaval shunt in the normal dog","volume":"78","author":"Gurll","year":"1980"},{"key":"ref10","series-title":"Nucl Med Commun","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1097\/00006231-199606000-00011","article-title":"Hepatic perfusion index in portal hypertension of cirrhotic and non-cirrhotic aetiologies","volume":"17","author":"Shikare","year":"1996"},{"key":"ref11","series-title":"Pflugers Arch","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1007\/BF00656719","article-title":"The hepatic haemodynamic response to acute portal venous blood flow reductions in the dog","volume":"399","author":"Mathie","year":"1983"},{"key":"ref12","series-title":"J Comput Assist Tomogr","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1097\/00004728-199505000-00016","article-title":"Liver perfusion studied with ultrafast CT","volume":"19","author":"Blomley","year":"1995"},{"issue":"(suppl 5)","key":"ref13","series-title":"Invest Radiol","doi-asserted-by":"publisher","first-page":"S72","DOI":"10.1097\/00004424-199311001-00023","article-title":"Contrast bolus dynamic computed tomography for the measurement of solid organ perfusion","volume":"28","author":"Blomley","year":"1993"},{"key":"ref14","series-title":"Clin Nucl Med","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1097\/00003072-199907000-00007","article-title":"Hepatic perfusion changes in patients with cirrhosis indices of hepatic arterial blood flow","volume":"24","author":"Koranda","year":"1999"},{"key":"ref15","series-title":"Acad Radiol","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/S1076-6332(03)80370-7","article-title":"Measuring portal venous perfusion with contrast-enhanced CT: comparison of direct and indirect methods","volume":"9","author":"Tsushima","year":"2002"},{"key":"ref16","series-title":"Vet Radiol Ultrasound","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1111\/j.1740-8261.2002.tb01049.x","article-title":"Doppler measurement of splanchnic blood flow during digestion in unsedated normal dogs","volume":"43","author":"Riesen","year":"2002"},{"key":"ref17","series-title":"J Am Vet Med Assoc","first-page":"925","article-title":"Use of transcolonic 99mtechnetium-pertechnetate as a screening test for portosystemic shunts in dogs","volume":"196","author":"Koblik","year":"1990"},{"key":"ref18","series-title":"Vet Rec","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1136\/vr.144.13.333","article-title":"Progressive remission of portosystemic shunting in 23 dogs after partial closure of congenital portosystemic shunts","volume":"144","author":"Meyer","year":"1999"},{"key":"ref19","series-title":"J Am Vet Med Assoc","first-page":"1770","article-title":"Use of transcolonic portal scintigraphy to monitor blood flow and progressive postoperative attenuation of partially ligated single extrahepatic portosystemic shunts in dogs","volume":"204","author":"Van Vechten","year":"1994"},{"key":"ref20","series-title":"J Am Vet Med Assoc","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.2460\/javma.2001.218.1116","article-title":"Evaluation of interoperator variance in shunt fraction calculation after transcolonic scintigraphy for diagnosis of portosystemic shunts in dogs and cats","volume":"218","author":"Samii","year":"2001"}],"container-title":["American Journal of Veterinary Research"],"original-title":[],"link":[{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/ajvr\/68\/9\/ajvr.68.9.970.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/ajvr\/68\/9\/ajvr.68.9.970.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/ajvr\/68\/9\/ajvr.68.9.970.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T12:18:45Z","timestamp":1741349925000},"score":1,"resource":{"primary":{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/ajvr\/68\/9\/ajvr.68.9.970.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,9]]},"references-count":20,"journal-issue":{"issue":"9"},"URL":"https:\/\/doi.org\/10.2460\/ajvr.68.9.970","relation":{},"ISSN":["0002-9645"],"issn-type":[{"value":"0002-9645","type":"print"}],"subject":[],"published":{"date-parts":[[2007,9]]}}}