{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T09:43:48Z","timestamp":1791193428699,"version":"4.1.0"},"reference-count":15,"publisher":"American Veterinary Medical Association (AVMA)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2008,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Objective<\/jats:bold>\u2014To determine effects of regional variation, interobserver variability, and vessel selection on quantitative vascular variables derived by dynamic contrast-enhanced computed tomography (DCE-CT) of the brain of clinically normal dogs.<\/jats:p>\n<jats:p><jats:bold>Animals<\/jats:bold>\u201414 adult dogs with no evidence of CNS dysfunction.<\/jats:p>\n<jats:p><jats:bold>Procedures<\/jats:bold>\u2014Dogs were randomly assigned to 4 groups, and DCE-CT was performed at the level of the frontal lobe, rostral portion of the parietal-temporal lobes, caudal portions of the parietal-temporal lobes, or occipital lobe\u2013cerebellum for groups 1 to 4, respectively. Cerebral blood flow (CBF), cerebral blood volume (CBV), and permeability in gray and white matter for both a large and small artery were calculated and compared. Values among 3 observers and 4 regions of the brain were calculated and compared.<\/jats:p>\n<jats:p><jats:bold>Results<\/jats:bold>\u2014Significant interobserver variability was detected for CBF and permeability in white matter. Values calculated for large and small arteries were correlated for CBV and CBF but not for permeability. Overall mean \u00b1 SD for CBF, CBV, and permeability in gray matter was 53.5 \u00b1 27.7 mL\/min\/100 g, 2.9 \u00b1 1.4 mL\/100 g, and 1.4 \u00b1 2.2 mL\/min\/100 g, respectively. Mean for CBF, CBV, and permeability in white matter was 44.2 \u00b1 28.5 mL\/min\/100 g, 2.5 \u00b1 1.5 mL\/100 g, and 0.9 \u00b1 0.7 mL\/min\/100 g, respectively. Values did not differ significantly among brain regions.<\/jats:p>\n<jats:p><jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Significant regional variations were not detected for quantitative vascular variables in the brain of clinically normal dogs. However, interobserver variability and vessel selection have an important role in variable estimation.<\/jats:p>","DOI":"10.2460\/ajvr.69.1.45","type":"journal-article","created":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T21:52:34Z","timestamp":1199224354000},"page":"45-50","source":"Crossref","is-referenced-by-count":13,"title":["Quantitative assessment of blood volume, blood flow, and permeability of the brain of clinically normal dogs by use of dynamic contrast-enhanced computed tomography"],"prefix":"10.2460","volume":"69","author":[{"given":"Kristi L.","family":"Peterson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander G.","family":"MacLeod","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik R.","family":"Wisner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard 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of human brain tumors: quantitative assessment of blood volume, blood flow, and microvascular permeability: report of two cases","volume":"23","author":"Roberts","year":"2002"},{"key":"ref14","series-title":"J Comput Assist Tomogr","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1097\/00004728-199301000-00020","article-title":"Noninvasive CT determination of arterial blood concentration of meglumine iothalamate","volume":"17","author":"Lapin","year":"1993"},{"key":"ref15","series-title":"Ann Neurol","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1002\/ana.10136","article-title":"Prognostic accuracy of cerebral blood flow measurement by perfusion computed tomography, at the time of emergency room admission, in acute stroke patients","volume":"51","author":"Wintermark","year":"2002"}],"container-title":["American Journal of Veterinary 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