{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T06:56:03Z","timestamp":1760079363600,"version":"3.38.0"},"reference-count":52,"publisher":"American Veterinary Medical Association (AVMA)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2008,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Objective<\/jats:bold>\u2014To compare the content of substance P, vasoactive intestinal polypeptide, and neurofilament 200 in biopsy specimens taken from the abomasal wall of healthy cows of 2 breeds.<\/jats:p>\n<jats:p><jats:bold>Sample Population<\/jats:bold>\u2014Biopsy specimens taken from different sites of the abomasal wall from 20 German Holstein cows and 20 German Fleckvieh cows.<\/jats:p>\n<jats:p><jats:bold>Procedures<\/jats:bold>\u2014Biopsy specimens were examined immunohistochemically, and the content of substance P, vasoactive intestinal polypeptide, and neurofilament 200 was determined by measuring the immunoreactive areas.<\/jats:p>\n<jats:p><jats:bold>Results<\/jats:bold>\u2014Significant differences between the breeds were detected. Substance P-immuno-reactive area in the corpus abomasi was significantly smaller in the German Holsteins (geometric mean \u00b1 geometric SD, 679 \u00b1 1.83 \u03bcm<jats:sup>2<\/jats:sup>) than in the German Fleckvieh cows (1,020 \u00b1 1.65 \u03bcm<jats:sup>2<\/jats:sup>). Concerning vasoactive intestinal polypeptide, differences between breeds were not significant. Overall nerve density in the antral abomasal wall was significantly greater in German Holsteins than in German Fleckvieh cows (immunoreactive areas for neurofilament 200 in German Holsteins was 4,842 \u00b1 1.29 \u03bcm<jats:sup>2<\/jats:sup> and in German Fleckvieh cows was 3,333 \u00b1 1.63 \u03bcm<jats:sup>2<\/jats:sup>).<\/jats:p>\n<jats:p><jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014The significantly lower content of substance P in the corpus abomasi could explain why German Holstein cows are predisposed to abomasal displacement, compared with German Fleckvieh cows, in which this disease is a rare finding.<\/jats:p>","DOI":"10.2460\/ajvr.69.10.1247","type":"journal-article","created":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T12:30:52Z","timestamp":1222864252000},"page":"1247-1253","source":"Crossref","is-referenced-by-count":9,"title":["Evaluation of differences between breeds for substance P, vasoactive intestinal polypeptide, and neurofilament 200 in the abomasal wall of cattle"],"prefix":"10.2460","volume":"69","author":[{"given":"Marlene","family":"Sickinger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rudolf","family":"Leiser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"Failing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"Doll","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"J Dairy Sci","doi-asserted-by":"publisher","first-page":"159","DOI":"10.3168\/jds.S0022-0302(05)72674-6","article-title":"Metabolic predictors of displaced abomasum in dairy cattle","volume":"88","author":"LeBlanc","year":"2005"},{"key":"ref2","series-title":"J Dairy Sci","doi-asserted-by":"publisher","first-page":"4287","DOI":"10.3168\/jds.S0022-0302(04)73573-0","article-title":"Genetic selection for health traits using producer-recorded data. 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