{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T14:38:28Z","timestamp":1770215908146,"version":"3.49.0"},"reference-count":23,"publisher":"American Veterinary Medical Association (AVMA)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Objective<\/jats:bold>\u2014To compare the effects of candesartan cilexetil and enalapril maleate on right ventricular myocardial remodeling in dogs with experimentally induced pulmonary stenosis.<\/jats:p>\n<jats:p><jats:bold>Animals<\/jats:bold>\u201424 Beagles.<\/jats:p>\n<jats:p><jats:bold>Procedures<\/jats:bold>\u201418 dogs underwent pulmonary arterial banding (PAB) to induce right ventricular pressure overload, and 6 healthy dogs underwent sham operations (thoracotomy only [sham-operated group]). Dogs that underwent PAB were allocated to receive 1 of 3 treatments (6 dogs\/group): candesartan (1 mg\/kg, PO, q 24 h [PABC group]), enalapril (0.5 mg\/kg, PO, q 24 h [PABE group]), or no treatment (PABNT group). Administration of treatments was commenced the day prior to surgery; control dogs received no cardiac medications. Sixty days after surgery, right ventricular wall thickness was assessed echocardiographi-cally and plasma renin activity, angiotensin-converting enzyme activity, and angiotensin I and II concentrations were assessed; all dogs were euthanatized, and collagenous fiber area, cardiomyocyte diameter, and tissue angiotensin-converting enzyme and chymase-like activities in the right ventricle were evaluated.<\/jats:p>\n<jats:p><jats:bold>Results<\/jats:bold>\u2014After 60 days of treatment, right ventricular wall thickness, cardiomyocyte diameter, and collagenous fiber area in the PABNT and PABE groups were significantly increased, compared with values in the PABC and sham-operated groups. Chymase-like activity was markedly greater in the PABE group than in other groups.<\/jats:p>\n<jats:p><jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Results indicated that treatment with candesartan but not enalapril effectively prevented myocardial remodeling in dogs with experimentally induced subacute right ventricular pressure overload.<\/jats:p>","DOI":"10.2460\/ajvr.69.12.1574","type":"journal-article","created":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T13:50:38Z","timestamp":1228139438000},"page":"1574-1579","source":"Crossref","is-referenced-by-count":5,"title":["Comparison of the effects of candesartan cilexetil and enalapril maleate on right ventricular myocardial remodeling in dogs with experimentally induced pulmonary stenosis"],"prefix":"10.2460","volume":"69","author":[{"given":"Tsuyoshi","family":"Yamane","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoko","family":"Fujii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kensuke","family":"Orito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaori","family":"Osamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takao","family":"Kanai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshito","family":"Wakao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Basic Res Cardiol","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1007\/BF02005828","article-title":"Contribution of each ventricular wall to ventricular interdependence","volume":"83","author":"Santamore","year":"1988"},{"key":"ref2","series-title":"Life Sci","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1016\/j.lfs.2004.04.006","article-title":"Time course sequences of angiotensin converting enzyme and chymase-like activities during development of right ventricular hypertrophy induced by pulmonary artery constriction in dogs","volume":"75","author":"Orito","year":"2004"},{"key":"ref3","series-title":"J Vet Cardiol","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.jvc.2005.07.005","article-title":"Increased chymase-like activity in a dog with congenital pulmonic stenosis","volume":"9","author":"Fujii","year":"2007"},{"key":"ref4","series-title":"Metabolism","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1016\/j.metabol.2003.12.021","article-title":"Candesartan, an angiotensin II receptor blocker, improves left ventricular hypertrophy and insulin resistance","volume":"53","author":"Anan","year":"2004"},{"key":"ref5","series-title":"J Vet Intern Med","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1111\/j.1939-1676.1998.tb02101.x","article-title":"Comparison of some pharmacokinetic parameters of 5 angiotensin-converting enzyme inhibitors in normal beagles","volume":"12","author":"Hamlin","year":"1998"},{"key":"ref6","series-title":"J Am Vet Med Assoc","first-page":"1573","article-title":"Effects of enalapril maleate on survival of dogs with naturally acquired heart failure. 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