{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T15:27:46Z","timestamp":1775575666312,"version":"3.50.1"},"reference-count":25,"publisher":"American Veterinary Medical Association (AVMA)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2008,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Objective<\/jats:bold>\u2014To compare morphometric measurements and serum insulin-like growth factor (IGF-1) concentration in cats with and without hypertrophic cardiomyopathy (HCM), and assess the hypothesis that cats with HCM have larger body size and skeletal features and higher serum IGF-1 concentrations than healthy cats.<\/jats:p>\n<jats:p><jats:bold>Animals<\/jats:bold>\u201425 cats with HCM and 22 healthy control cats.<\/jats:p>\n<jats:p><jats:bold>Procedures<\/jats:bold>\u2014Physical examination and echocardiography were performed to classify cats into the HCM and control groups. Data collected from each cat included diet history, body weight, body condition score, lengths of the humerus and 4th and 12th thoracic vertebrae, heart size, head length and width, and abdominal circumferences. Comparisons of these variables were made between groups.<\/jats:p>\n<jats:p><jats:bold>Results<\/jats:bold>\u2014Body condition score in HCM-affected and control cats did not differ significantly. However, median head width; lengths of the head, 4th and 12th thoracic vertebrae, and humerus; and body weight in the HCM-affected group were significantly greater than values in the control group. Median serum concentration of IGF-1 was not significantly different between groups.<\/jats:p>\n<jats:p><jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014These data suggested that among the study cats, those with HCM were skeletally larger, but not more obese, than healthy cats. Whether this was attributable to differences in early growth or other causes requires additional investigation.<\/jats:p>","DOI":"10.2460\/ajvr.69.8.1061","type":"journal-article","created":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T12:15:37Z","timestamp":1217592937000},"page":"1061-1066","source":"Crossref","is-referenced-by-count":22,"title":["Comparisons of morphometric measurements and serum insulin-like growth factor concentration in healthy cats and cats with hypertrophic cardiomyopathy"],"prefix":"10.2460","volume":"69","author":[{"given":"Vicky K.","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa M.","family":"Freeman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John E.","family":"Rush","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Circulation","doi-asserted-by":"publisher","first-page":"3172","DOI":"10.1161\/01.CIR.99.24.3172","article-title":"Familial hypertrophic cardiomyopathy in maine coon cats: an animal model of human disease","volume":"99","author":"Kittleson","year":"1999"},{"key":"ref2","series-title":"Circulation","doi-asserted-by":"publisher","first-page":"2645","DOI":"10.1161\/01.CIR.92.9.2645","article-title":"Echocardiographic assessment of spontaneously occurring feline hypertrophic cardiomyopathy: an animal model of human disease","volume":"92","author":"Fox","year":"1995"},{"key":"ref3","series-title":"Hum Mol Genet","doi-asserted-by":"publisher","first-page":"3587","DOI":"10.1093\/hmg\/ddi386","article-title":"A cardiac myosin binding protein c mutation in the maine coon cat with familial hypertrophic cardiomyopathy","volume":"14","author":"Meurs","year":"2005"},{"key":"ref4","series-title":"Genomics","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.ygeno.2007.04.007","article-title":"A substitution mutation in the myosin binding protein C gene in ragdoll hypertrophic cardiomyopathy","volume":"90","author":"Meurs","year":"2007"},{"key":"ref5","series-title":"J Clin Invest","first-page":"209","article-title":"Soy diet worsens heart disease in mice","volume":"116","author":"Stauffer","year":"2006"},{"key":"ref6","series-title":"J Muscle Res Cell Motil","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1023\/B:JURE.0000021353.82449.9e","article-title":"Swimming exercise in infancy has beneficial effect on the hearts in cardiomyopathic Syrian hamsters","volume":"25","author":"Tatsuguchi","year":"2004"},{"key":"ref7","series-title":"Circulation","doi-asserted-by":"publisher","first-page":"1999","DOI":"10.1161\/01.CIR.0000161369.71722.10","article-title":"Overweight in children and adolescents: pathophysiology, consequences, prevention, and treatment","volume":"111","author":"Daniels","year":"2005"},{"key":"ref8","series-title":"Circulation","doi-asserted-by":"publisher","first-page":"3488","DOI":"10.1161\/01.CIR.0000149713.48317.27","article-title":"Childhood adiposity as a predictor of cardiac mass in adulthood","volume":"110","author":"Li","year":"2004"},{"key":"ref9","series-title":"Circulation","doi-asserted-by":"publisher","first-page":"1108","DOI":"10.1161\/01.CIR.0000118500.23649.DF","article-title":"Is slower early growth beneficial for long-term cardiovascular health?","volume":"109","author":"Singhal","year":"2004"},{"key":"ref10","series-title":"Circulation","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1161\/CIRCULATIONAHA.106.617811","article-title":"Promotion of faster weight gain in infants born small for gestational age. 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