{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T13:45:56Z","timestamp":1775742356888,"version":"3.50.1"},"reference-count":34,"publisher":"American Veterinary Medical Association (AVMA)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2009,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Objective<\/jats:bold>\u2014To compare the time to desaturation in healthy dogs that breathed oxygen or room air for 3 minutes before induction of anesthesia.<\/jats:p>\n<jats:p><jats:bold>Animals<\/jats:bold>\u201420 healthy dogs.<\/jats:p>\n<jats:p><jats:bold>Procedures<\/jats:bold>\u2014Dogs were sedated with morphine and acepromazine maleate. Dogs received a 3-minute treatment of room air or oxygen (100 mL\/kg\/min) via face mask. Arterial blood samples were collected before and after treatment to determine Pa<jats:sc>CO<\/jats:sc><jats:sub>2<\/jats:sub>, Pa<jats:sc>O<\/jats:sc><jats:sub>2<\/jats:sub>, pH, and Sa<jats:sc>O<\/jats:sc><jats:sub>2<\/jats:sub>; propofol (6 mg\/kg, IV) was injected during a 7-second period, and the dogs were intubated. A lingual pulse oximeter probe was placed. Dogs remained disconnected from the breathing circuit until Sp<jats:sc>O<\/jats:sc><jats:sub>2<\/jats:sub> equaled 90% (desaturation point) and then connected and ventilated until the Sp<jats:sc>O<\/jats:sc><jats:sub>2<\/jats:sub> was \u2265 97%. Arterial blood samples were collected and Sp<jats:sc>O<\/jats:sc><jats:sub>2<\/jats:sub> was recorded every 30 seconds for 4 minutes and then every minute until the desaturation point. Times to first breath and the desaturation point were recorded. Data were collected at 0, 5, 30, 60, 90, 120, and 150 seconds.<\/jats:p>\n<jats:p><jats:bold>Results<\/jats:bold>\u2014Mean \u00b1 SEM time to desaturation differed significantly between dogs treated with room air (69.6 \u00b1 10.6 seconds) and oxygen (297.8 \u00b1 42.0 seconds). Lowest mean Pa<jats:sc>O<\/jats:sc><jats:sub>2<\/jats:sub> and Sa<jats:sc>O<\/jats:sc><jats:sub>2<\/jats:sub> when dogs were breathing room air were 62 \u00b1 6.3 mm Hg and 82.3 \u00b1 4%, respectively, at 30 seconds.<\/jats:p>\n<jats:p><jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Preoxygenation for 3 minutes increased the time to desaturation in healthy dogs sedated with acepromazine and morphine in which anesthesia was induced with propofol.<\/jats:p>","DOI":"10.2460\/ajvr.70.11.1333","type":"journal-article","created":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T07:13:53Z","timestamp":1257059633000},"page":"1333-1338","source":"Crossref","is-referenced-by-count":86,"title":["Comparison of time to desaturation between preoxygenated and nonpreoxygenated dogs following sedation with acepromazine maleate and morphine and induction of anesthesia with propofol"],"prefix":"10.2460","volume":"70","author":[{"given":"Erin M.","family":"McNally","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheilah A.","family":"Robertson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luisito S.","family":"Pablo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Textbook of critical care","first-page":"234","article-title":"Interpretation of blood gases. 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