{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T22:33:57Z","timestamp":1778279637001,"version":"3.51.4"},"reference-count":33,"publisher":"American Veterinary Medical Association (AVMA)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Objective<\/jats:bold>\u2014To determine the effects of perzinfotel, butorphanol, and their combination on the minimal alveolar concentration (MAC) of isoflurane in cats.<\/jats:p>\n<jats:p><jats:bold>Animals<\/jats:bold>\u20147 healthy sexually intact cats (4 males and 3 females), aged 12 to 17 months and weighing 2.8 to 4.6 kg.<\/jats:p>\n<jats:p><jats:bold>Procedures<\/jats:bold>\u2014In a crossover design, saline (0.9% NaCl) solution, perzinfotel (2.5 to 15 mg\/kg; IV, IM, and SC), butorphanol tartrate (0.2 mg\/kg, IM), or a combination of 5 mg of perzinfotel\/kg and 2 mg of butorphanol tartrate\/kg (both IM) was administered to 6 cats before 7 separate episodes of anesthesia with isoflurane in oxygen. Heart rate, arterial blood pressure, bispectral index (BIS), and inspiration and expiration concentrations of isoflurane were continuously monitored. The isoflurane MAC was determined twice during anesthesia.<\/jats:p>\n<jats:p><jats:bold>Results<\/jats:bold>\u2014IV, IM, and SC administration of perzinfotel at 2.5 to 15 mg\/kg resulted in a significant decrease in mean isoflurane MAC by 43.3% to 68.0%. The BIS significantly increased after perzinfotel administration via the same routes at 2.5 to 15 mg\/kg and after perzinfotelbutorphanol administration IM. Blood pressure was significantly higher after perzinfotel was administered at 5 mg\/kg, IM; 10 mg\/kg, IV; and 10 mg\/kg, SC than after saline solution administration.<\/jats:p>\n<jats:p><jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Perzinfotel administration decreased the isoflurane MAC and increased several BIS and blood pressure values in anesthetized cats. Administration of perzinfotel prior to isoflurane anesthesia may improve anesthetic safety by reducing inhalant anesthetic requirements and improving cardiovascular function during anesthesia. <jats:italic>(Am J Vet Res<\/jats:italic> 2010;71:1270\u20131276)<\/jats:p>","DOI":"10.2460\/ajvr.71.11.1270","type":"journal-article","created":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T07:04:22Z","timestamp":1288595062000},"page":"1270-1276","source":"Crossref","is-referenced-by-count":9,"title":["Effects of perzinfotel, butorphanol tartrate, and a butorphanol-perzinfotel combination on the minimum alveolar concentration of isoflurane in cats"],"prefix":"10.2460","volume":"71","author":[{"given":"Raphael","family":"J. Zwijnenberg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"L. del Rio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"A. 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