{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:54:55Z","timestamp":1787025295386,"version":"build-2736575974"},"reference-count":54,"publisher":"American Veterinary Medical Association (AVMA)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Objective<\/jats:bold>\n                    \u2014To determine whether a mutation in the fibrillin 2 gene (\n                    <jats:italic>FBN2<\/jats:italic>\n                    ) is associated with canine hip dysplasia (CHD) and osteoarthritis in dogs.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Animals<\/jats:bold>\n                    \u2014-1,551 dogs.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Procedures<\/jats:bold>\n                    \u2014Hip conformation was measured radiographically. The\n                    <jats:italic>FBN2<\/jats:italic>\n                    was sequenced from genomic DNA of 21 Labrador Retrievers and 2 Greyhounds, and a haplotype in intron 30 of\n                    <jats:italic>FBN2<\/jats:italic>\n                    was sequenced in 90 additional Labrador Retrievers and 143 dogs of 6 other breeds. Steady-state values of\n                    <jats:italic>FBN2<\/jats:italic>\n                    mRNA and control genes were measured in hip joint tissues of fourteen 8-month-old Labrador Retriever\u2013Greyhound crossbreeds.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results<\/jats:bold>\n                    \u2014The Labrador Retrievers homozygous for a 10-bp deletion haplotype in intron 30 of\n                    <jats:italic>FBN2<\/jats:italic>\n                    had significantly worse CHD as measured via higher distraction index and extended-hip joint radiograph score and a lower Norberg angle and dorsolateral subluxation score. Among 143 dogs of 6 other breeds, those homozygous for the same deletion haplotype also had significantly worse radiographic CHD. Among the 14 crossbred dogs, as the dorsolateral subluxation score decreased, the capsular\n                    <jats:italic>FBN2<\/jats:italic>\n                    mRNA increased significantly. Those dogs with incipient hip joint osteoarthritis had significantly increased capsular\n                    <jats:italic>FBN2<\/jats:italic>\n                    mRNA, compared with those dogs without osteoarthritis. Dogs homozygous for the\n                    <jats:italic>FBN2<\/jats:italic>\n                    deletion haplotype had significantly less\n                    <jats:italic>FBN2<\/jats:italic>\n                    mRNA in their femoral head articular cartilage.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\n                    \u2014The\n                    <jats:italic>FBN2<\/jats:italic>\n                    deletion haplotype was associated with CHD. Capsular gene expression of\n                    <jats:italic>FBN2<\/jats:italic>\n                    was confounded by incipient secondary osteoarthritis in dysplastic hip joints. Genes influencing complex traits in dogs can be identified by genome-wide screening, fine mapping, and candidate gene screening.\n                  <\/jats:p>","DOI":"10.2460\/ajvr.72.4.530","type":"journal-article","created":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T06:11:02Z","timestamp":1301638262000},"page":"530-540","source":"Crossref","is-referenced-by-count":33,"title":["Evaluation of a fibrillin 2 gene haplotype associated with hip dysplasia and incipient osteoarthritis in dogs"],"prefix":"10.2460","volume":"72","author":[{"given":"Steven G.","family":"Friedenberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy van den 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