{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T18:03:11Z","timestamp":1770746591338,"version":"3.49.0"},"reference-count":30,"publisher":"American Veterinary Medical Association (AVMA)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Objective<\/jats:bold>\u2014To compare values of urodynamic measurements of cats with idiopathic cystitis (IC) with previously published data for healthy female cats.<\/jats:p>\n<jats:p><jats:bold>Animals<\/jats:bold>\u201411 female cats with IC.<\/jats:p>\n<jats:p><jats:bold>Procedures<\/jats:bold>\u20142 sequential cystometrograms and 2 urethral pressure profiles were obtained for each cat. All tracings were evaluated for evidence of overactive urinary bladder (OAB). Maximum urethral pressure (MUP), maximum urethral closure pressure (MUCP), and functional profile length were recorded.<\/jats:p>\n<jats:p><jats:bold>Results<\/jats:bold>\u2014Only 3 cats had obvious micturition events. None of the 11 cats had evidence of OAB. Although not significant, threshold pressure was lower in cats with IC than in healthy cats (mean \u00b1 SD, 89.0 \u00b1 12.0 cm H<jats:sub>2<\/jats:sub>O vs 75.7 \u00b1 16.3 cm H<jats:sub>2<\/jats:sub>O, respectively); however, the total volume infused was significantly lower in cats with IC (4.8 \u00b1 2.1 mL\/kg vs 8.3 \u00b1 3.2 mL\/kg). The MUCP was significantly higher in cats with IC than in healthy cats (158.0 \u00b1 47.7 cm H<jats:sub>2<\/jats:sub>O vs 88.9 \u00b1 23.9 cm H<jats:sub>2<\/jats:sub>O, respectively). The MUP was also significantly higher in all portions of the urethra in cats with IC.<\/jats:p>\n<jats:p><jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014No evidence of OAB was identified in any cat evaluated; therefore, medications used to target this abnormality did not appear justified. The high MUCP in cats with IC suggested that \u03b1<jats:sub>1<\/jats:sub>-adrenoceptor antagonists or skeletal muscle relaxants may be useful in this disease, and if these data were applicable to male cats, then \u03b1<jats:sub>1<\/jats:sub>-adrenoceptor antagonism may help prevent recurrent obstructive IC. Further studies are indicated to determine the effects, if any, these drugs might have in cats with IC.<\/jats:p>","DOI":"10.2460\/ajvr.72.4.578","type":"journal-article","created":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T10:11:02Z","timestamp":1301652662000},"page":"578-582","source":"Crossref","is-referenced-by-count":16,"title":["Urodynamic evaluation of female cats with idiopathic cystitis"],"prefix":"10.2460","volume":"72","author":[{"given":"Christine H.","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. A. Tony","family":"Buffington","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew O.","family":"Fraser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jodi L.","family":"Westropp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Am J Vet Res","doi-asserted-by":"publisher","first-page":"731","DOI":"10.2460\/ajvr.67.4.731","article-title":"Evaluation of the effects of stress in cats with idiopathic cystitis","volume":"67","author":"Westropp","year":"2006"},{"key":"ref2","series-title":"Am J Vet Res","doi-asserted-by":"publisher","first-page":"203","DOI":"10.2460\/ajvr.68.2.203","article-title":"In vivo evaluation of alpha(2)-adrenoceptors in cats with idiopathic cystitis","volume":"68","author":"Westropp","year":"2007"},{"key":"ref3","series-title":"Exp Neurol","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/j.expneurol.2005.01.011","article-title":"Abnormal excitability in capsaicin-responsive DRG neurons from cats with feline interstitial cystitis","volume":"193","author":"Sculptoreanu","year":"2005"},{"key":"ref4","series-title":"J Urol","doi-asserted-by":"publisher","first-page":"2494","DOI":"10.1097\/01.ju.0000095566.63870.66","article-title":"Small adrenal glands in cats with feline interstitial cystitis","volume":"170","author":"Westropp","year":"2003"},{"key":"ref5","series-title":"Am J Physiol Renal Physiol","doi-asserted-by":"publisher","first-page":"F540","DOI":"10.1152\/ajprenal.2000.278.4.F540","article-title":"Urothelial pathophysiological changes in feline interstitial cystitis: a human model","volume":"278","author":"Lavelle","year":"2000"},{"key":"ref6","series-title":"J Urol","doi-asserted-by":"publisher","first-page":"1801","DOI":"10.1016\/S0022-5347(01)66201-3","article-title":"Decreased urine glycosaminoglycan excretion in cats with interstitial cystitis","volume":"155","author":"Buffington","year":"1996"},{"key":"ref7","series-title":"Am J Physiol Renal Physiol","doi-asserted-by":"publisher","first-page":"F423","DOI":"10.1152\/ajprenal.00056.2003","article-title":"Feline interstitial cystitis results in mechanical hypersensitivity and altered ATP release from bladder urothelium","volume":"285","author":"Birder","year":"2003"},{"key":"ref8","series-title":"J Neurosci","doi-asserted-by":"publisher","first-page":"8063","DOI":"10.1523\/JNEUROSCI.22-18-08063.2002","article-title":"Beta-adrenoceptor agonists stimulate endothelial nitric oxide synthase in rat urinary bladder urothelial cells","volume":"22","author":"Birder","year":"2002"},{"key":"ref9","series-title":"Am J Physiol Renal Physiol","doi-asserted-by":"publisher","first-page":"F1084","DOI":"10.1152\/ajprenal.00118.2004","article-title":"Alterations in P2X and P2Y purinergic receptor expression in urinary bladder from normal cats and cats with interstitial cystitis","volume":"287","author":"Birder","year":"2004"},{"key":"ref10","series-title":"J Urol","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1016\/S0022-5347(01)69129-8","article-title":"In vivo models of interstitial cystitis","volume":"167","author":"Westropp","year":"2002"},{"key":"ref11","series-title":"Eur J Obstet Gynecol Reprod Biol","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.ejogrb.2009.02.050","article-title":"Differentiating interstitial cystitis from similar conditions commonly seen in gynecologic practice","volume":"144","author":"Dell","year":"2009"},{"key":"ref12","series-title":"Neurourol Urodyn","doi-asserted-by":"publisher","first-page":"944","DOI":"10.1002\/nau.20729","article-title":"Bladder outlet obstruction in painful bladder syndrome\/interstitial cystitis","volume":"28","author":"Cameron","year":"2009"},{"key":"ref13","series-title":"Am J Vet Res","doi-asserted-by":"publisher","first-page":"290","DOI":"10.2460\/ajvr.70.2.290","article-title":"Evaluation of urodynamic procedures in female cats anesthetized with low and high doses of isoflurane and propofol","volume":"70","author":"Cohen","year":"2009"},{"key":"ref14","series-title":"Am J Vet Res","first-page":"1472","article-title":"Electromyographic and urethral pressure evaluations: assessment of urethral function in female and ovariohysterectomized female cats","volume":"47","author":"Gregory","year":"1986"},{"key":"ref15","series-title":"Neurourol Urodyn","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1002\/nau.20687","article-title":"Status of international consensus on interstitial cystitis\/bladder pain syndrome\/painful bladder syndrome: 2008 snapshot","volume":"28","author":"Hanno","year":"2009"},{"key":"ref16","series-title":"Int J Clin Pract","doi-asserted-by":"publisher","first-page":"1926","DOI":"10.1111\/j.1742-1241.2008.01931.x","article-title":"Diagnostic options for early identification and management of interstitial cystitis\/painful bladder syndrome","volume":"62","author":"Forrest","year":"2008"},{"key":"ref17","series-title":"J Urol","doi-asserted-by":"publisher","first-page":"2550","DOI":"10.1016\/j.juro.2009.01.106","article-title":"Urodynamic findings of the painful bladder syndrome\/interstitial cystitis: a comparison with idiopathic overactive bladder","volume":"181","author":"Kim","year":"2009"},{"key":"ref18","series-title":"J Urol","doi-asserted-by":"publisher","first-page":"1409","DOI":"10.1016\/S0022-5347(17)36923-9","article-title":"Idiopathic reduced bladder storage versus interstitial cystitis","volume":"148","author":"Awad","year":"1992"},{"key":"ref19","series-title":"Rev Urol","first-page":"9","article-title":"Diagnosis of interstitial cystitis\/painful bladder syndrome in patients with overactive bladder symptoms","volume":"9","author":"Macdiarmid","year":"2007"},{"key":"ref20","series-title":"Am J Vet Res","first-page":"919","article-title":"Urethral pressure response to smooth and skeletal muscle relaxants in anesthetized, adult male cats with naturally acquired urethral obstruction","volume":"56","author":"Straeter-Knowlen","year":"1995"},{"key":"ref21","series-title":"World J Urol","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1007\/s003450100224","article-title":"Tolterodine: an overview","volume":"19","author":"Wefer","year":"2001"},{"key":"ref22","series-title":"Urology","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1016\/j.urology.2005.04.042","article-title":"Increased prevalence of interstitial cystitis in women with detrusor overactivity refractory to anticholinergic therapy","volume":"66","author":"Minaglia","year":"2005"},{"key":"ref23","series-title":"J Urol","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1097\/01.ju.0000145591.35569.9e","article-title":"Bladder Adelta afferent nerve activity in normal cats and cats with feline interstitial cystitis","volume":"173","author":"Roppolo","year":"2005"},{"key":"ref24","series-title":"Urology","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1016\/S0090-4295(00)00845-1","article-title":"Treatments used in women with interstitial cystitis: the interstitial cystitis data base (ICDB) study experience. The Interstitial Cystitis Data Base Study Group","volume":"56","author":"Rovner","year":"2000"},{"key":"ref25","series-title":"Urology","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/0090-4295(75)90012-6","article-title":"Combined video\/pressure\/flow cystourethrog-raphy in female patients with voiding disturbances","volume":"5","author":"Webster","year":"1975"},{"key":"ref26","series-title":"Urology","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/S0090-4295(01)01639-9","article-title":"Targeting afferent hyperexcitability for therapy of the painful bladder syndrome","volume":"59","author":"Yoshimura","year":"2002"},{"key":"ref27","series-title":"J Neurol Sci","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.jns.2008.01.002","article-title":"The effects of visual, auditory, and mixed cues on choice reaction in Parkinson's disease","volume":"269","author":"Akamatsu","year":"2008"},{"key":"ref28","series-title":"Neurourol Urodyn","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1002\/nau.20641","article-title":"Heart rate variability: an objective measure of autonomic activity and bladder sensations during urodynamics","volume":"28","author":"Mehnert","year":"2009"},{"key":"ref29","series-title":"J Urol","doi-asserted-by":"publisher","first-page":"1983","DOI":"10.1097\/01.ju.0000158452.15915.e2","article-title":"Psychophysical evidence of hypersensitivity in subjects with interstitial cystitis","volume":"173","author":"Ness","year":"2005"},{"key":"ref30","series-title":"Urodynamics","first-page":"64","article-title":"Principles of urodynamics","author":"Abrams","year":"2006"}],"container-title":["American Journal of Veterinary Research"],"original-title":[],"link":[{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/ajvr\/72\/4\/ajvr.72.4.578.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/ajvr\/72\/4\/ajvr.72.4.578.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/ajvr\/72\/4\/ajvr.72.4.578.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T12:27:08Z","timestamp":1741350428000},"score":1,"resource":{"primary":{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/ajvr\/72\/4\/ajvr.72.4.578.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4]]},"references-count":30,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.2460\/ajvr.72.4.578","relation":{},"ISSN":["0002-9645"],"issn-type":[{"value":"0002-9645","type":"print"}],"subject":[],"published":{"date-parts":[[2011,4]]}}}