{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,8]],"date-time":"2025-03-08T05:23:13Z","timestamp":1741411393696,"version":"3.38.0"},"reference-count":30,"publisher":"American Veterinary Medical Association (AVMA)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Objective<\/jats:bold>\u2014To investigate the ability of perzinfotel (an N-methyl-<jats:sc>d<\/jats:sc>-aspartate receptor antagonist) and a proprietary phospholipase A<jats:sub>2<\/jats:sub> (PLA<jats:sub>2<\/jats:sub>) inhibitor to attenuate lameness in dogs with sodium urate (SU)\u2013induced synovitis.<\/jats:p>\n<jats:p><jats:bold>Animals<\/jats:bold>\u20148 adult dogs.<\/jats:p>\n<jats:p><jats:bold>Procedures<\/jats:bold>\u2014A blinded 4-way crossover study was performed. Dogs received perzinfotel (10 mg\/kg), a proprietary PLA<jats:sub>2<\/jats:sub> inhibitor (10 mg\/kg), carprofen (4.4 mg\/kg; positive control treatment), or no treatment (negative control treatment). On the fourth day after initiation of treatment, synovitis was induced via intra-articular injection of SU 1 hour before administration of the last treatment dose. Ground reaction forces were measured and clinical lameness evaluations were performed before (baseline [time 0]) and 2, 4, 6, 8, 12, and 25 hours after SU injection. There was a 21-day washout period between subsequent treatments. Data were analyzed via repeated-measures ANOVAs.<\/jats:p>\n<jats:p><jats:bold>Results<\/jats:bold>\u2014Peak vertical force (PVF) and vertical impulse (VI) values for negative control and perzinfotel treatments were significantly lower at 2 and 4 hours, compared with baseline values. Values for PVF and VI for the PLA<jats:sub>2<\/jats:sub> inhibitor and positive control treatments did not differ from baseline values at any time points. Between-treatment comparisons revealed significantly higher PVF and VI values for the positive control treatment than for the negative control and perzinfotel treatments at 2 and 4 hours. Values for VI were higher for PLA<jats:sub>2<\/jats:sub> inhibitor treatment than for negative control treatment at 2 hours.<\/jats:p>\n<jats:p><jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Perzinfotel did not significantly alter SU\u2013induced lameness. The proprietary PLA<jats:sub>2<\/jats:sub> inhibitor attenuated lameness but not as completely as did carprofen.<\/jats:p>","DOI":"10.2460\/ajvr.72.6.757","type":"journal-article","created":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T07:51:55Z","timestamp":1306914715000},"page":"757-763","source":"Crossref","is-referenced-by-count":7,"title":["Effect of perzinfotel and a proprietary phospholipase A2 inhibitor on kinetic gait and subjective lameness scores in dogs with sodium urate-induced synovitis"],"prefix":"10.2460","volume":"72","author":[{"given":"Steven C.","family":"Budsberg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bryan T.","family":"Torres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raphael J.","family":"Zwijnenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. 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