{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T15:49:20Z","timestamp":1784130560665,"version":"3.55.0"},"reference-count":50,"publisher":"American Veterinary Medical Association (AVMA)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Objective<\/jats:bold>\n                    \u2014To evaluate and compare circulating concentrations of islet amyloid polypeptide (IAPP), insulin, and glucose in nondiabetic cats classified by body condition score (BCS) and in cats with naturally occurring diabetes mellitus.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Animals<\/jats:bold>\n                    \u2014109 (82 nondiabetic, 21 nonketoacidotic diabetic, and 6 ketoacidotic diabetic) cats.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Procedures<\/jats:bold>\n                    \u2014Cats were examined and BCSs were assessed on a scale of 1 to 9. After food was withheld for 12 hours, blood was collected and plasma concentrations of IAPP and serum concentrations of insulin and glucose were measured. Differences in these values were evaluated among nondiabetic cats grouped according to BCS and in diabetic cats grouped as ketoacidotic or nonketoacidotic on the basis of clinicopathologic findings. Correlations were determined among variables.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results<\/jats:bold>\n                    \u2014In nondiabetic cats, BCS was significantly and positively correlated with circulating IAPP and insulin concentrations. Mean plasma IAPP concentrations were significantly different between cats with BCSs of 5 and 7, and mean serum insulin concentrations were significantly different between cats with BCSs of 5 and 8. Serum glucose concentrations were not significantly different among nondiabetic cats. Mean IAPP concentrations were similar between nonketoacidotic diabetic cats and nondiabetic cats with BCSs of 8 or 9. Mean IAPP concentrations were significantly reduced in ketoacidotic diabetic cats, compared with those of nondiabetic cats with BCSs of 6 through 8 and of nonketoacidotic diabetic cats.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\n                    \u2014Results indicated that increased BCS (a measure of obesity) is associated with increased circulating concentrations of IAPP and insulin in nondiabetic cats.\n                  <\/jats:p>","DOI":"10.2460\/ajvr.72.8.1052","type":"journal-article","created":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T03:09:30Z","timestamp":1312168170000},"page":"1052-1058","source":"Crossref","is-referenced-by-count":14,"title":["Evaluation of plasma islet amyloid polypeptide and serum glucose and insulin concentrations in nondiabetic cats classified by body condition score and in cats with naturally occurring diabetes mellitus"],"prefix":"10.2460","volume":"72","author":[{"given":"Michael S.","family":"Henson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca L.","family":"Hegstad-Davies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M.","family":"Hardy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. Jane","family":"Armstrong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"Jordan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth H.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy D.","family":"O'Brien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Am J Pathol","first-page":"416","article-title":"Spontaneous diabetes mellitus-islet amyloid complex in adult cats","volume":"125","author":"Johnson","year":"1986"},{"key":"ref2","series-title":"Inst Lab Anim Res J","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1093\/ilar.47.3.234","article-title":"Feline models of diabetes mellitus","volume":"47","author":"Henson","year":"2006"},{"key":"ref3","series-title":"Am J Pathol","first-page":"414","article-title":"Islet amyloid in type 2 human diabetes mellitus and adult diabetic cats contains a novel putative polypeptide hormone","volume":"127","author":"Westermark","year":"1987"},{"key":"ref4","series-title":"Proc Natl Acad Sci U S A","doi-asserted-by":"publisher","first-page":"3881","DOI":"10.1073\/pnas.84.11.3881","article-title":"Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a neuropeptide-like protein also present in normal islet cells","volume":"84","author":"Westermark","year":"1987"},{"key":"ref5","series-title":"Am J Pathol","first-page":"1","article-title":"Immunolocalization of islet amyloid polypeptide (IAPP) in pancreatic beta cells using peroxidase antiperoxidase (PAP) and protein A-gold techniques","volume":"130","author":"Johnson","year":"1988"},{"key":"ref6","series-title":"Diabetes","doi-asserted-by":"publisher","first-page":"752","DOI":"10.2337\/diab.39.6.752","article-title":"Effects of meal ingestion on plasma amylin concentration in NIDDM and nondiabetic humans","volume":"39","author":"Butler","year":"1990"},{"key":"ref7","series-title":"Diabetes","doi-asserted-by":"publisher","first-page":"1701","DOI":"10.2337\/diab.40.12.1701","article-title":"Islet amyloid polypeptide and insulin secretion from isolated perfused pancreas of fed, fasted, glucose-treated, and dexamethasone-treated rats","volume":"40","author":"O'Brien","year":"1991"},{"key":"ref8","series-title":"FEBS Lett","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/0014-5793(89)81467-X","article-title":"Sequence divergence in a specific region of islet amyloid polypeptide (IAPP) explains differences in islet amyloid formation between species","volume":"251","author":"Betsholtz","year":"1989"},{"key":"ref9","series-title":"Exp Cell Res","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1016\/0014-4827(89)90407-2","article-title":"Islet amyloid polypeptide (IAPP):cDNA cloning and identification of an amyloidogenic region associated with the species-specific occurrence of age-related diabetes mellitus","volume":"183","author":"Betsholtz","year":"1989"},{"key":"ref10","series-title":"Vet Pathol","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1177\/030098589603300501","article-title":"Islet amyloid and islet amyloid polypeptide in cynomolgus macaques (Macaca fascicularis): an animal model of human non-insulin-dependent diabetes mellitus","volume":"33","author":"O'Brien","year":"1996"},{"key":"ref11","series-title":"Diabetes","doi-asserted-by":"publisher","first-page":"491","DOI":"10.2337\/diabetes.48.3.491","article-title":"The mechanism of islet amyloid polypeptide toxicity is membrane disruption by intermediate-sized toxic amyloid particles","volume":"48","author":"Janson","year":"1999"},{"key":"ref12","series-title":"Endocr Rev","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1210\/er.2007-0037","article-title":"Islet amyloid in type 2 diabetes, and the toxic oligomer hypothesis","volume":"29","author":"Haataja","year":"2008"},{"key":"ref13","series-title":"Diabetes","doi-asserted-by":"publisher","first-page":"2899","DOI":"10.2337\/db07-1842","article-title":"Islets in type 2 diabetes: in honor of Dr. Robert C. Turner","volume":"57","author":"Bonner-Weir","year":"2008"},{"key":"ref14","series-title":"Am J Pathol","first-page":"245","article-title":"Impaired glucose tolerance is associated with increased islet amyloid polypeptide (IAPP) immunoreactivity in pancreatic beta cells","volume":"135","author":"Johnson","year":"1989"},{"key":"ref15","series-title":"Diabetologia","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/BF00500385","article-title":"Plasma islet amyloid polypeptide (amylin) concentrations and their responses to oral glucose in type 2 (non-insulin-dependent) diabetic patients","volume":"34","author":"Sanke","year":"1991"},{"key":"ref16","series-title":"Diabetes Res Clin Pract","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/0168-8227(92)90074-2","article-title":"Plasma islet amyloid polypeptide concentrations in obesity, impaired glucose tolerance and non-insulin-dependent diabetes mellitus","volume":"15","author":"Enoki","year":"1992"},{"key":"ref17","series-title":"J Vet Intern Med","first-page":"177","article-title":"Fructosamine. A new parameter for diagnosis and metabolic control in diabetic dogs and cats","volume":"7","author":"Reusch","year":"1993"},{"issue":"5\/6","key":"ref18","series-title":"Feline Pract","first-page":"13","article-title":"Development and validation of a body condition score system for cats: a clinical tool","volume":"25","author":"LaFlamme","year":"1997"},{"key":"ref19","series-title":"Clin Chem","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1093\/clinchem\/11.9.869","article-title":"A new method for the continuous monitoring of blood glucose by measurement of dissolved oxygen","volume":"11","author":"Kadish","year":"1965"},{"key":"ref20","series-title":"Am J Pathol","doi-asserted-by":"publisher","first-page":"2143","DOI":"10.1016\/S0002-9440(10)64852-3","article-title":"A feline model of experimentally induced islet amyloidosis","volume":"157","author":"Hoenig","year":"2000"},{"key":"ref21","series-title":"FEBS Lett","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/0014-5793(90)80210-A","article-title":"Co-secretion of amylin and insulin from isolated rat pancreas","volume":"262","author":"Fehmann","year":"1990"},{"key":"ref22","series-title":"J Comp Pathol","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/0021-9975(86)90031-9","article-title":"Immunohisto-chemical morphometry of pancreatic endocrine cells in diabetic, normoglycemic glucose-intolerant and normal cats","volume":"96","author":"O'Brien","year":"1986"},{"key":"ref23","series-title":"Am J Vet Res","first-page":"463","article-title":"Diagnosis of naturally acquired type-I and type-II diabetes mellitus in cats","volume":"54","author":"Kirk","year":"1993"},{"key":"ref24","series-title":"J Vet Intern Med","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1111\/j.1939-1676.2002.tb02382.x","article-title":"Influence of glucose dosage on interpretation of intravenous glucose tolerance tests in lean and obese cats","volume":"16","author":"Hoenig","year":"2002"},{"key":"ref25","series-title":"J Feline Med Surg","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1053\/jfms.2002.0166","article-title":"Plasma leptin concentrations are independently associated with insulin sensitivity in lean and overweight cats","volume":"4","author":"Appleton","year":"2002"},{"key":"ref1","series-title":"Am J Pathol","first-page":"416","article-title":"Spontaneous diabetes mellitus-islet amyloid complex in adult cats","volume":"125","author":"Johnson","year":"1986"},{"key":"ref2","series-title":"Inst Lab Anim Res J","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1093\/ilar.47.3.234","article-title":"Feline models of diabetes mellitus","volume":"47","author":"Henson","year":"2006"},{"key":"ref3","series-title":"Am J Pathol","first-page":"414","article-title":"Islet amyloid in type 2 human diabetes mellitus and adult diabetic cats contains a novel putative polypeptide hormone","volume":"127","author":"Westermark","year":"1987"},{"key":"ref4","series-title":"Proc Natl Acad Sci U S A","doi-asserted-by":"publisher","first-page":"3881","DOI":"10.1073\/pnas.84.11.3881","article-title":"Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a neuropeptide-like protein also present in normal islet cells","volume":"84","author":"Westermark","year":"1987"},{"key":"ref5","series-title":"Am J Pathol","first-page":"1","article-title":"Immunolocalization of islet amyloid polypeptide (IAPP) in pancreatic beta cells using peroxidase antiperoxidase (PAP) and protein A-gold techniques","volume":"130","author":"Johnson","year":"1988"},{"key":"ref6","series-title":"Diabetes","doi-asserted-by":"publisher","first-page":"752","DOI":"10.2337\/diab.39.6.752","article-title":"Effects of meal ingestion on plasma amylin concentration in NIDDM and nondiabetic humans","volume":"39","author":"Butler","year":"1990"},{"key":"ref7","series-title":"Diabetes","doi-asserted-by":"publisher","first-page":"1701","DOI":"10.2337\/diab.40.12.1701","article-title":"Islet amyloid polypeptide and insulin secretion from isolated perfused pancreas of fed, fasted, glucose-treated, and dexamethasone-treated rats","volume":"40","author":"O'Brien","year":"1991"},{"key":"ref8","series-title":"FEBS Lett","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/0014-5793(89)81467-X","article-title":"Sequence divergence in a specific region of islet amyloid polypeptide (IAPP) explains differences in islet amyloid formation between species","volume":"251","author":"Betsholtz","year":"1989"},{"key":"ref9","series-title":"Exp Cell Res","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1016\/0014-4827(89)90407-2","article-title":"Islet amyloid polypeptide (IAPP):cDNA cloning and identification of an amyloidogenic region associated with the species-specific occurrence of age-related diabetes mellitus","volume":"183","author":"Betsholtz","year":"1989"},{"key":"ref10","series-title":"Vet Pathol","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1177\/030098589603300501","article-title":"Islet amyloid and islet amyloid polypeptide in cynomolgus macaques (Macaca fascicularis): an animal model of human non-insulin-dependent diabetes mellitus","volume":"33","author":"O'Brien","year":"1996"},{"key":"ref11","series-title":"Diabetes","doi-asserted-by":"publisher","first-page":"491","DOI":"10.2337\/diabetes.48.3.491","article-title":"The mechanism of islet amyloid polypeptide toxicity is membrane disruption by intermediate-sized toxic amyloid particles","volume":"48","author":"Janson","year":"1999"},{"key":"ref12","series-title":"Endocr Rev","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1210\/er.2007-0037","article-title":"Islet amyloid in type 2 diabetes, and the toxic oligomer hypothesis","volume":"29","author":"Haataja","year":"2008"},{"key":"ref13","series-title":"Diabetes","doi-asserted-by":"publisher","first-page":"2899","DOI":"10.2337\/db07-1842","article-title":"Islets in type 2 diabetes: in honor of Dr. Robert C. Turner","volume":"57","author":"Bonner-Weir","year":"2008"},{"key":"ref14","series-title":"Am J Pathol","first-page":"245","article-title":"Impaired glucose tolerance is associated with increased islet amyloid polypeptide (IAPP) immunoreactivity in pancreatic beta cells","volume":"135","author":"Johnson","year":"1989"},{"key":"ref15","series-title":"Diabetologia","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/BF00500385","article-title":"Plasma islet amyloid polypeptide (amylin) concentrations and their responses to oral glucose in type 2 (non-insulin-dependent) diabetic patients","volume":"34","author":"Sanke","year":"1991"},{"key":"ref16","series-title":"Diabetes Res Clin Pract","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/0168-8227(92)90074-2","article-title":"Plasma islet amyloid polypeptide concentrations in obesity, impaired glucose tolerance and non-insulin-dependent diabetes mellitus","volume":"15","author":"Enoki","year":"1992"},{"key":"ref17","series-title":"J Vet Intern Med","first-page":"177","article-title":"Fructosamine. A new parameter for diagnosis and metabolic control in diabetic dogs and cats","volume":"7","author":"Reusch","year":"1993"},{"issue":"5\/6","key":"ref18","series-title":"Feline Pract","first-page":"13","article-title":"Development and validation of a body condition score system for cats: a clinical tool","volume":"25","author":"LaFlamme","year":"1997"},{"key":"ref19","series-title":"Clin Chem","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1093\/clinchem\/11.9.869","article-title":"A new method for the continuous monitoring of blood glucose by measurement of dissolved oxygen","volume":"11","author":"Kadish","year":"1965"},{"key":"ref20","series-title":"Am J Pathol","doi-asserted-by":"publisher","first-page":"2143","DOI":"10.1016\/S0002-9440(10)64852-3","article-title":"A feline model of experimentally induced islet amyloidosis","volume":"157","author":"Hoenig","year":"2000"},{"key":"ref21","series-title":"FEBS Lett","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/0014-5793(90)80210-A","article-title":"Co-secretion of amylin and insulin from isolated rat pancreas","volume":"262","author":"Fehmann","year":"1990"},{"key":"ref22","series-title":"J Comp Pathol","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/0021-9975(86)90031-9","article-title":"Immunohisto-chemical morphometry of pancreatic endocrine cells in diabetic, normoglycemic glucose-intolerant and normal cats","volume":"96","author":"O'Brien","year":"1986"},{"key":"ref23","series-title":"Am J Vet Res","first-page":"463","article-title":"Diagnosis of naturally acquired type-I and type-II diabetes mellitus in cats","volume":"54","author":"Kirk","year":"1993"},{"key":"ref24","series-title":"J Vet Intern Med","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1111\/j.1939-1676.2002.tb02382.x","article-title":"Influence of glucose dosage on interpretation of intravenous glucose tolerance tests in lean and obese cats","volume":"16","author":"Hoenig","year":"2002"},{"key":"ref25","series-title":"J Feline Med Surg","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1053\/jfms.2002.0166","article-title":"Plasma leptin concentrations are independently associated with insulin sensitivity in lean and overweight cats","volume":"4","author":"Appleton","year":"2002"}],"container-title":["American Journal of Veterinary Research"],"original-title":[],"link":[{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/ajvr\/72\/8\/ajvr.72.8.1052.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/ajvr\/72\/8\/ajvr.72.8.1052.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/ajvr\/72\/8\/ajvr.72.8.1052.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T20:10:39Z","timestamp":1775765439000},"score":1,"resource":{"primary":{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/ajvr\/72\/8\/ajvr.72.8.1052.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8]]},"references-count":50,"journal-issue":{"issue":"8"},"URL":"https:\/\/doi.org\/10.2460\/ajvr.72.8.1052","relation":{},"ISSN":["0002-9645"],"issn-type":[{"value":"0002-9645","type":"print"}],"subject":[],"published":{"date-parts":[[2011,8]]}}}