{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:25:29Z","timestamp":1763036729537,"version":"3.38.0"},"reference-count":16,"publisher":"American Veterinary Medical Association (AVMA)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Objective<\/jats:bold>\u2014To determine morphological and mechanical properties of trabecular bone of horses with a bone fragility syndrome (BFS; including silicate-associated osteoporosis).<\/jats:p>\n<jats:p><jats:bold>Sample<\/jats:bold>\u2014Cylindrical trabecular bone samples from the distal aspects of cadaveric third metacarpal bones of 39 horses (19 horses with a BFS [BFS bone samples] and 20 horses without a BFS [control bone samples]).<\/jats:p>\n<jats:p><jats:bold>Procedures<\/jats:bold>\u2014Bone samples were imaged via micro-CT for determination of bone volume fraction; apparent and mean mineralized bone densities; and trabecular number, thickness, and separation. Bone samples were compressed to failure for determination of apparent elastic modulus and stresses, strains, and strain energy densities for yield, ultimate, and failure loads. Effects of BFS and age of horses on variables were determined.<\/jats:p>\n<jats:p><jats:bold>Results<\/jats:bold>\u2014BFS bone samples had 25% lower bone volume fraction, 28% lower apparent density, 18% lower trabecular number and thickness, and 16% greater trabecular separation versus control bone samples. The BFS bone samples had 22% lower apparent modulus and 32% to 33% lower stresses, 10% to 18% lower strains, and 41 % to 52% lower strain energy densities at yield, ultimate, and failure loads, compared with control bone samples. Differences between groups of bone samples were not detected for mean mineral density and trabecular anisotropy.<\/jats:p>\n<jats:p><jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Results suggested that horses with a BFS had osteopenia and compromised trabecular bone function, consistent with bone deformation and pathological fractures that develop in affected horses. Effects of this BFS may be systemic, and bones other than those that are clinically affected had changes in morphological and mechanical properties.<\/jats:p>","DOI":"10.2460\/ajvr.73.11.1742","type":"journal-article","created":{"date-parts":[[2012,10,29]],"date-time":"2012-10-29T19:32:20Z","timestamp":1351539140000},"page":"1742-1751","source":"Crossref","is-referenced-by-count":11,"title":["Mechanical and morphological properties of trabecular bone samples obtained from third metacarpal bones of cadavers of horses with a bone fragility syndrome and horses unaffected by that syndrome"],"prefix":"10.2460","volume":"73","author":[{"given":"Jennifer E.","family":"Symons","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel C.","family":"Entwistle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda M.","family":"Arens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanya C.","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blaine A.","family":"Christiansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David P.","family":"Fyhrie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan M.","family":"Stover","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"J Am Vet Med Assoc","doi-asserted-by":"publisher","first-page":"1694","DOI":"10.2460\/javma.232.11.1694","article-title":"Clinical and scintigraphic findings in horses with a bone fragility disorder: 16 cases (1980\u20132006)","volume":"232","author":"Anderson","year":"2008"},{"key":"ref2","series-title":"Vet Pathol","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1177\/0300985810385151","article-title":"Osteoporosis associated with pulmonary silicosis in an equine bone fragility syndrome","volume":"48","author":"Arens","year":"2011"},{"key":"ref3","series-title":"Fractures and bone deformities in 18 horses with silicosis","first-page":"311","author":"Durham","year":"2006"},{"key":"ref4","series-title":"J Orthop Res","doi-asserted-by":"publisher","first-page":"1272","DOI":"10.1002\/jor.20892","article-title":"Material properties are related to stress fracture callus and porosity of cortical bone tissue at affected and unaffected sites","volume":"27","author":"Entwistle","year":"2009"},{"key":"ref5","series-title":"J Biomech","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1016\/0021-9290(96)00020-6","article-title":"Calcium buffering is required to maintain bone stiffness in saline solution","volume":"29","author":"Gustafson","year":"1996"},{"key":"ref6","series-title":"J Opt Soc Am A","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1364\/JOSAA.1.000612","article-title":"Practical cone-beam algorithm","volume":"1","author":"Feldkamp","year":"1984"},{"key":"ref7","series-title":"J Bone Miner Res","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1359\/jbmr.1999.14.7.1167","article-title":"Direct three-dimensional morphometric analysis of human cancellous bone: microstructural data from spine, femur, iliac crest, and calcaneus","volume":"14","author":"Hildebrand","year":"1999"},{"key":"ref8","series-title":"Bone","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/8756-3282(93)90245-6","article-title":"Quantification of connectivity in cancellous bone, with special emphasis on 3-D reconstructions","volume":"14","author":"Odgaard","year":"1993"},{"key":"ref9","series-title":"J Microsc","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1046\/j.1365-2818.1997.1340694.x","article-title":"A new method for the model-independent assessment of thickness in three-dimensional images","volume":"185","author":"Hildebrand","year":"1997"},{"key":"ref10","series-title":"J Orthop Res","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1002\/jor.1100150115","article-title":"Systematic and random errors in compression testing of trabecular bone","volume":"15","author":"Keaveny","year":"1997"},{"key":"ref11","series-title":"J Orthop Res","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/S0736-0266(01)00138-3","article-title":"Stiff and strong compressive properties are associated with brittle post-yield behavior in equine compact bone material","volume":"20","author":"Les","year":"2002"},{"key":"ref12","series-title":"J Biomech","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1016\/0021-9290(93)90021-6","article-title":"Theoretical analysis of the experimental artifact in trabecular bone compressive modulus","volume":"26","author":"Keaveny","year":"1993"},{"key":"ref13","series-title":"J Bone Joint Surg Am","doi-asserted-by":"publisher","first-page":"954","DOI":"10.2106\/00004623-197759070-00021","article-title":"The compressive behavior of bone as a two-phase porous structure","volume":"59","author":"Carter","year":"1977"},{"key":"ref14","series-title":"J Biomed Mater Res","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1002\/jbm.820100409","article-title":"Postyield behavior of subchondral trabecular bone","volume":"10","author":"Hayes","year":"1976"},{"key":"ref15","series-title":"Skeletal tissue mechanics","first-page":"112","article-title":"Analysis of bone remodeling","volume":"98","author":"Martin","year":"1998"},{"key":"ref16","series-title":"J Am Vet Med Assoc","article-title":"Comparison of scapular ultrasound, physical examination, and serum biomarkers of bone turnover versus bone 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