{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T02:02:24Z","timestamp":1768615344423,"version":"3.49.0"},"reference-count":43,"publisher":"American Veterinary Medical Association (AVMA)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Objective<\/jats:bold>\u2014To evaluate the effect of 6% hydroxyethyl starch (HES) solution, with a molecular weight of 130 kDa and a degree of substitution of 0.42, on canine platelet function in vitro.<\/jats:p>\n<jats:p><jats:bold>Samples<\/jats:bold>\u2014Blood samples from 31 healthy adult dogs.<\/jats:p>\n<jats:p><jats:bold>Procedures<\/jats:bold>\u2014Citrated blood was diluted with saline (0.9% NaCl) solution or HES 130\/0.42 in ratios of 1:9 (ie, 1 part saline solution or HES 130\/0.42 and 9 parts blood) and 1:3. Platelet plug formation time (closure time [Ct]) was measured with a platelet function analyzer and cartridges coated with collagen and ADP.<\/jats:p>\n<jats:p><jats:bold>Results<\/jats:bold>\u2014Median baseline Ct with citrated blood was 84.0 seconds (interquartile range, 74.5 to 99.5 seconds). Results obtained with 1:9 dilutions with saline solution and HES 130\/0.42 were not significantly different from baseline results. The 1:3 dilutions with saline solution and HES 130\/0.42 resulted in median Cts of 96.0 seconds (interquartile range, 85.5 to 110.8 seconds) and 112.0 seconds (92.0 to 126.0 seconds), respectively. Results obtained with both 1:3 dilutions were significantly different from baseline results. The Ct obtained with the HES dilution was also significantly different from that of the 1:3 dilution with saline solution.<\/jats:p>\n<jats:p><jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Saline solution and HES 130\/0.42 in a 1:3 dilution affected canine platelet function by prolonging Cts. The HES 130\/0.42 had a significantly greater effect on canine platelets than did saline solution.<\/jats:p>","DOI":"10.2460\/ajvr.73.12.1908","type":"journal-article","created":{"date-parts":[[2012,11,23]],"date-time":"2012-11-23T17:26:48Z","timestamp":1353691608000},"page":"1908-1912","source":"Crossref","is-referenced-by-count":31,"title":["In vitro effect of hydroxyethyl starch 130\/0.42 on canine platelet function"],"prefix":"10.2460","volume":"73","author":[{"given":"Janine","family":"Classen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katja N.","family":"Adamik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Weber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Rubenbauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrin","family":"Hartmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Anesthesiology","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1097\/ALN.0b013e3181a7ec82","article-title":"Hydroxyethyl starches: different products\u2014different effects","volume":"111","author":"Westphal","year":"2009"},{"key":"ref2","series-title":"Clin Pharmacokinet","doi-asserted-by":"publisher","first-page":"681","DOI":"10.2165\/00003088-200544070-00002","article-title":"Pharmacokinetics of hydroxyethyl starch","volume":"44","author":"Jungheinrich","year":"2005"},{"key":"ref3","series-title":"Thromb Haemost","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1055\/s-0038-1657671","article-title":"Coagulation disorders caused by hydroxyethyl starch","volume":"78","author":"Treib","year":"1997"},{"key":"ref4","series-title":"Eur J Haematol","first-page":"168","article-title":"Influence of intravascular molecular weight of hydroxyethyl starch on platelets","volume":"56","author":"Treib","year":"1996"},{"key":"ref5","series-title":"Thromb Haemost","doi-asserted-by":"publisher","first-page":"1452","DOI":"10.1055\/s-0038-1649964","article-title":"HES 200\/0.5 is not HES 200\/0.5. 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